 | | Vol. 12.03 – 28 January, 2021 |
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| The basement membrane (BM) is a special type of ECM and presents the major barrier cancer cells have to overcome multiple times to form metastases. Investigators showed BM stiffness to be a major determinant of metastases formation in several tissues and identified netrin-4 as a key regulator of BM stiffness.
[Nature Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Serotonin 2B receptor (5-HT2B) antagonism resulted in collagen fiber redistribution to thinner collagen fibers which were more anisotropic, enhancing left ventricular contractility, while fibrotic tissue stiffness was decreased, limiting the hypertrophic response of uninjured cardiomyocytes.
[Circulation] |
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| Crohn’s disease muscularis propria cells produced an ECM scaffold which was in direct spatial and functional contact with the immediately overlaid creeping fat.
[Gut] |
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| In cell experiments, network formation of human umbilical vein endothelial cells within fibrinogen‐based hydrogels with different concentrations of hyaluronic acid were systematically studied.
[Small] |
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| Researchers hypothesized that enzymatic disruption of the tissue matrix results in a softer tissue, affecting the stiffness of embedded cell and nuclear structures.
[Small] |
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| To investigate the role of p53 in controlling tumor-immune cell crosstalk, scientists studied murine syngeneic models treated with HDM201, a potent and selective second generation MDM2 inhibitor.
[Cancer Research] |
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| Primary human airway smooth muscle cells from COPD and non-COPD smoking patients were stimulated with TGF-β1. Gene array analysis performed to identify differences in ECM expression.
[Thorax] |
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| The authors report that prostate cancer associated fibroblasts expressed a transcriptional-incompetent androgen receptor.
[Cell Death & Disease] |
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| Scientists present an in vitro dynamic compression bioreactor approach to monitor bone formation in scaffolds under cyclic loading.
[Communications Biology] |
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| To fast-track translation of therapies and to inform personalised medicine, researchers developed a whole-tissue ex vivo explant model that maintains viability, 3D multicellular architecture, and microenvironmental cues of human pancreatic tumors.
[Scientific Reports] |
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| TGF-β1-induced ECM production and myofibroblast differentiation were attenuated by Amphiregulin-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG). Investigators confirmed that upregulated AREG in the ureteral obstruction or adenine diet models was mainly localized in the distal tubules.
[Scientific Reports] |
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| The authors focus on the role of the microenvironment in the acquisition and/or maintenance of stem cell states in cancer in the context of resistance and metastasis. They further discuss the role of cancer stem cells in immune evasion through the course of metastasis, dormancy, and relapse.
[Trends in Cancer] |
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| Scientists provide a resourceful toolbox to build a wide variety of novel materials that can be designed to tackle the glyco-dysregulations seen in neuroinflammation.
[Cell Reports] |
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| The authors examine how lysyl oxidase family dysregulation in solid cancers contributes to disease progression and poor patient outcomes, as well as an evaluation of the preclinical landscape of LOX family targeting therapeutics.
[Cancers] |
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| Abeona Therapeutics Inc. held a successful Type B meeting with the US FDA to align with the Agency on the company’s proposal regarding co-primary endpoints for the pivotal Phase III VIITAL™ study of EB-101 in RDEB, a rare connective tissue disorder where those inflicted have a defect in the COL7A1 gene, leaving them unable to produce functioning type VII collagen which is necessary to anchor the dermal and epidermal layers of the skin.
[Abeona Therapeutics Inc.] |
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| 3D Systems announced its decision to significantly expand its development efforts focused on regenerative medicine and bioprinting solutions. This decision was driven by the tremendous progress made in collaboration with United Therapeutics Corporation and its organ manufacturing and transplantation-focused subsidiary, Lung Biotechnology PBC, on the development of 3D printing systems for solid-organ scaffolds.
[3D Systems Inc.] |
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| | Blood Research Institute – Milwaukee, Wisconsin, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Rutgers Cancer Institute of New Jersey – Rutgers, New Jersey, United States |
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| | University of Florida – Gainesville, Florida, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
