CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Viral Fibroblast Growth Factor, Matrix Metalloproteases, and Caspases are Associated with Enhancing Systemic Infection by Baculoviruses Researchers describe an elegant mechanism mediated by a baculovirus-encoded fibroblast growth factor that signals a previously undescribed stepwise cascade of protease activation wherein matrix metalloproteases activate effector caspases, leading to remodeling of basal lamina lining tracheal cells associated with the intestine and culminating in the establishment of efficient systemic infections. [Proc Natl Acad Sci U S A] Tetraspanin CD151 Regulates Growth of Mammary Epithelial Cells in Three-Dimensional Extracellular Matrix: Implication for Mammary Ductal Carcinoma In Situ Depletion of CD151 suppressed growth of HB2 cells, a nontumorigenic breast epithelial cell line, in 3D extracellular matrices and in Matrigel-based xenografts. [Cancer Res] Dynamic Shape Changes of Extracellular Matrix-Producing Cells Drive Morphogenesis of Ball-And-Socket Joints in the Fly Leg The results highlight the importance of dynamic cell behaviors in precise shaping of skeletal extracellular matrix architecture. [Development] Bone Regeneration Mediated by Biomimetic Mineralization of a Nanofiber Matrix Researchers report here on the use of self-assembling peptide nanostructured gels to promote bone regeneration that have the capacity to mineralize in biomimetic fashion. [Biomaterials] Bioprinting Vessel-Like Constructs Using Hyaluronan Hydrogels Crosslinked with Tetrahedral Polyethylene Glycol Tetracrylates Biofabrication of cell suspensions in tetra-acrylate derivative synthetic extracellular matrices demonstrates the feasibility of building bioartificial blood vessel-like constructs for research and potentially clinical uses. [Biomaterials] Interconnected Macroporous Poly(Ethylene Glycol) (PEG) Cryogels as a Cell Scaffold for Cartilage Tissue Engineering Results indicated that interconnected macroporous PEG cryogels successfully supported attachment, viability, proliferation, and biosynthetic activity of seeded chondrocytes. [Tissue Eng Part A] Tissue Engineering by Molecular Disassembly and Reassembly: Biomimetic Retention of Mechanically Functional Aggrecan in Hydrogel By altering the assembly of proteoglycan (PG) aggregates with hyaluronan with or without link proteins, which affects aggrecan retention, it may be possible to achieve the targeted levels of PG components in order to modulate the mechanical properties of the engineered construct for cartilage as well as other tissues containing PG and PG aggregates. [Tissue Eng Part C Methods] An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix In this study, a CLT1 peptide targeted G3 nanoglobular Mn(II)-DOTA monoamide conjugate was designed and synthesized as a targeted MRI contrast agent for molecular imaging of the fibrin-fibronectin complexes or oncofetal fibronectin in tumor stroma. [Mol Pharm] Hyperglycemic Conditions Modulate Connective Tissue Reorganization by Human Vascular Smooth Muscle Cells through Stimulation of Hyaluronan Synthesis High glucose concentration stimulated hyaluronan synthesis by vascular smooth muscle cells and modulated their ability to reorganize collagen-rich matrix. [Glycobiology] Altered Fibroblast Proteoglycan Production in COPD This study explores the hypothesis that altered depositions of proteoglycans in COPD lungs, and in particular versican and perlecan, is a result of dysregulated fibroblast proteoglycan production. [Respir Res]
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