Extracellular Matrix News Volume 1.07 | Jun 10 2010

TOP STORY

Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction
Researchers explored the mechanisms responsible for the fibrogenic effects of Smad3 by dissecting its role in modulating cardiac fibroblast phenotype and function. [Circ Res]

SCIENCE NEWS

Researchers Discover Mechanism that Limits Scar Formation
Researchers have discovered that an unexpected cellular response plays an important role in breaking down and inhibiting the formation of excess scar tissue in wound healing. [Press release from the University of Illinois at Chicago discussing online prepublication in Nature Cell Biology]

Helping Hearts, Spinal Cords and Tendons Heal Themselves
A researcher is currently trying to develop microscopic polymer fibers to help rebuild human tissue and speed the healing process. [Press release from Queen’s University discussing research presented at the Advanced Foods and Materials Network 6th Annual Conference]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

The Matricellular Protein CCN1 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing
Researchers show that the matricellular protein CCN1, which is dynamically expressed at sites of wound repair, can induce fibroblast senescence by binding to integrin alpha6beta1 and the heparan sulphate proteoglycans. [Nat Cell Biol]

Local Expression of Indoleamine 2,3 Dioxygenase in Syngeneic Fibroblasts Significantly Prolongs Survival of an Engineered Three-Dimensional Islets Allograft
Researchers introduce a novel composite three-dimensional islet graft equipped with a local immunosuppressive system that prevents islet allograft rejection without systemic anti-rejection agents. [Diabetes]

Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse After Coordinate Targeting of Integrin Alpha5Beta1 and Fibronectin
Researchers show that a specific heterodimer of beta1-integrin preferentially mediates a prosurvival signal in human breast cancer cells that can be specifically targeted for therapy. [Cancer Res]

A Mosaic Mouse Model of Astrocytoma Identifies AlphaVBeta8 Integrin as a Negative Regulator of Tumor Angiogenesis
Using mosaic mouse models of the malignant brain cancer, astrocytoma, researchers report that tumor cells induce pathological angiogenesis by suppressing expression of the extracellular matrix protein receptor alphaVbeta8 integrin. [Oncogene]

Spatiotemporal Induction of Matrix Metalloproteinase-9 Transcription After Discrete Myocardial Injury
Findings suggest that changes in a key determinant of extracellular matrix remodeling, in addition to changes in myocardial structure, can contribute to arrhythmogenesis around the region of myocardial injury. [FASEB J]

A Small Fibronectin-Mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation
Findings suggest that the bacterial protein CagL, a 26-kDa protein of the gastric pathogen and type-I carcinogen Helicobacter pylori, not only exhibits functional mimicry with fibronectin but is also capable of activating fibronectin-independent signaling events. [J Biol Chem]

Rac1-Mediated Mitochondrial H2O2 Regulates MMP-9 Gene Expression in Macrophages via Inhibition of SP-1 and AP-1
To investigate the contribution of aberrant matrix degradation to pulmonary fibrosis, researchers addressed the role of Rac1 in regulating expression of macrophage-specific matrix metalloproteinase-9 (MMP-9). [J Biol Chem]

Xenogeneic Extracellular Matrix as an Inductive Scaffold for Regeneration of a Functioning Musculotendinous Junction
The objective of this study was to determine the ability of an extracellular matrix-based scaffold to facilitate functional restoration of the distal gastrocnemius musculotendinous junction in a canine model following complete resection of the tissue. [Tissue Eng Part A]

Adrenal Extracellular Matrix (ECM) Scaffolds Support Adrenocortical Cell Proliferation and Function In Vitro
Researchers conclude that adrenal ECM supports endocrine function and proliferation of adrenocortical cells in vitro. [Tissue Eng Part A]

A Matrix Metalloproteinase Mediates Airway Remodeling in Drosophila
Whereas work in other developmental systems has demonstrated that matrix metalloproteinases (MMPs) are required for axial elongation occurring in localized growth zones, this study demonstrates that MMPs can also mediate interstitial matrix remodeling during growth of an organ system. [Dev Biol]

INDUSTRY NEWS

Cardium Announces Collagen Supply Agreement with Devro Medical for Planned Market Launch of Excellagen Product Candidate and Reports on Further Positive Healing Effects
Cardium Therapeutics announced that its wholly-owned subsidiary, Tissue Repair Company, has entered into a multi-year supply agreement with Devro Medical Limited for the supply of highly-refined fibrillar bovine type I collagen, an important component of Cardium’s new Excellagen formulated collagen product candidate, which is pending FDA 510(k) clearance. [Cardium Therapeutics Press Release]

ISSCR Launches Web Site Providing Information on Stem Cell Treatments
The International Society for Stem Cell Research (ISSCR) announced that it has launched “A Closer Look at Stem Cell Treatments” (www.closerlookatstemcells.org), a web site to arm patients, their families and doctors with information they need to make decisions about stem cell treatments. [International Society for Stem Cell Research Press Release]

Kensey Nash to Present at the Jefferies 2010 Global Life Sciences Conference
Kensey Nash Corporation is scheduled to present at the Jefferies 2010 Global Life Sciences Conference. [Kensey Nash Corporation Press Release]

POLICY NEWS

FDA Announces Collaboration with Drugs.com
The U.S. Food and Drug Administration announced that it will collaborate with the web site Drugs.com to expand access to the FDA’s consumer health information. [Food and Drug Administration, United States]

Administrative Supplements to Increase Public Awareness of Pediatric Cancers and Available Treatments and Research (NOT-CA-10-026) [National Institutes of Health, United States]

2010 Biological License Application Approvals [Food and Drug Administration, United States]

2010 Biological Device Application Approvals [Food and Drug Administration, United States]

Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety Public Workshop (Update) [Food and Drug Administration, United States]

EVENTS

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

21st Meeting of the European Association for Cancer Research (EACR) 
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Regenerative Medicine Iasi (ReMedIs) 2010
July 15-18, 2010
Iasi, Romania

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

The European Molecular Biology Organization (EMBO) Meeting – Advancing the Life Sciences
September 4-7, 2010
Barcelona, Spain

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States 

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

9th Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

4th International Conference on Biofabrication
October 4-6, 2010
Philadelphia, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

BioStar 2010 – 4th Congress on Regenerative Biology and Medicine
October 13-15, 2010
Stuttgart, Germany

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Translational Excellence in Regenerative Medicine – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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