Extracellular Matrix News Volume 1.17 | Aug 26 2010

Bioactive Polymer/Extracellular Matrix Scaffolds Fabricated with a Flow Perfusion Bioreactor for Cartilage Tissue Engineering 
Electrospun poly(epsilon-caprolactone) microfiber scaffolds, coated with cartilaginous extracellular matrix, were fabricated by first culturing chondrocytes under dynamic conditions in a flow perfusion bioreactor and then decellularizing the cellular constructs. [Biomaterials]

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A Better Way to Grow Stem Cells
Researchers have devised a synthetic surface that includes no foreign animal material and allows stem cells to stay alive and continue reproducing themselves for at least three months. [Press release from the Massachusetts Institute of Technology discussing online prepublication in Nature Materials]

Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells
Researchers developed the first chemically defined, xeno-free, feeder-free synthetic substrates to support robust self-renewal of fully dissociated human embryonic stem and induced pluripotent stem cells. [Nat Mater]

The Effects of Processing Methods Upon Mechanical and Biologic Properties of Porcine Dermal Extracellular Matrix Scaffolds
Researchers conclude that processing steps evaluated in the present study affect content, mechanical strength, and/or cytocompatibility of the resultant porcine dermal extracellular matrix (ECM), and therefore care must be taken in choosing appropriate processing steps to maintain the beneficial effects of ECM in biologic scaffolds. [Biomaterials]

Dense Type I Collagen Matrices that Support Cellular Remodeling and Microfabrication for Studies of Tumor Angiogenesis and Vasculogenesis in Vitro
Researchers worked with hydrated type I collagen at mass fractions between 3.0 and 20 mg/ml to define the range of densities over which the matrices support both microfabrication and cellular remodeling. [Biomaterials]

The Improvement of Fibroblast Growth on Hydrophobic Biopolyesters by Coating with Polyhydroxyalkanoate Granule Binding Protein PhaP Fused with Cell Adhesion Motif RGD
Results indicated that PhaP-RGD could be used as a coating material to improve cell growth on hydrophobic biopolyesters for implant tissue engineering purposes. [Biomaterials]

Matrilin-1 A-Domains: Structural and Functional Investigations Reveal Insights into Their Role in Cartilage Extracellular Matrix Assembly
Researchers have identified new characteristics of the matrilin-1 A-domains by describing their glycosylation state and the effect of N-glycan chains on their structure, thermal stability and protein-protein interactions. [J Biol Chem]
 
Dynamic Culture Enhances Stem Cell Infiltration and Modulates Extracellular Matrix Production on Aligned Electrospun Nanofibrous Scaffolds
Researchers demonstrated that a simple modification to standard in vitro culture conditions effectively improves cellular ingress into electrospun scaffolds, resolving a challenge which has until now limited the utility of these materials for various tissue engineering applications. [Acta Biomater]

Osteogenic Differentiation of Human Mesenchymal Stem Cells Synergistically Enhanced by Biomimetic Peptide Amphiphiles Combined with Conditioned Media
Peptide amphiphiles were investigated as an extracellular matrix-mimicking biomaterial to provide an instructive microenvironment for human mesenchymal stem cells in an effort to guide osteogenic differentiation. [Acta Biomater]

Autofluorescence Assessment of Extracellular Matrices of a Cartilage-Like Tissue Construct Using a Fluorescent Image Analyzer
Researchers investigated the use of a fluorescent image analyzer and the application of fluorescence intensity measurements to describe and evaluate a tissue-engineered cartilage-like tissue construct. [J Tissue Eng Regen Med]
 
Extracellular Matrix-Derived Products Modulate Endothelial and Progenitor Cell Migration and Proliferation in Vitro and Stimulate Regenerative Healing in Vivo
Studies suggest that matrix-derived products can stimulate regenerative healing and avert scar tissue formation in adult mammals. [Matrix Biol]

In Vivo Evaluation of MMP Sensitive High-Molecular Weight HA-Based Hydrogels for Bone Tissue Engineering
Matrix metalloproteinase (MMP) sensitive hyaluronic acid (HA)-based hydrogel could become useful scaffolds in bone tissue engineering with improvements on tissue remodeling rates and regeneration activity. [J Biomed Mater Res A]

Life Technologies Announces Agreement to Acquire Ion Torrent
Life Technologies Corporation announced a definitive agreement to acquire Ion Torrent for $375 million in cash and stock. [Life Technologies Corporation Press Release]

Stem Cell Agency Commits $243 Million, Expands Team Approach to Developing New Therapies
The Governing Board of the California Institute for Regenerative Medicine approved the concept for up to $243 million round of funding to move stem cell-based therapies to clinical trial. [California Institute for Regenerative Medicine Press Release]

Federal Judge: Obama Stem Cell Policy Halted
Research on embryonic stem cells funded by the U.S. government must stop immediately for a court-ordered review, Judge Royce Lamberth of the U.S. District Court for the District of Columbia ruled. [United States District Court for the District of Columbia]

NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]

Universities, Scientists Urge NIH to Narrow Conflicts Rule
The biomedical research community is reacting with concern to a proposal from the National Institutes of Health (NIH) to clamp down on financial conflicts of interest in research. [National Institutes of Health, United States]

Lawrence A. Tabak Named Principal Deputy Director NIH
National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States]

Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-11-003) [National Institutes of Health, United States]

NIH-RAID Updates on Program Scope and Procedures: Biologics Manufacture, Lead Selection, and Product Development Plans (NOT-RM-10-012) [National Institutes of Health, United States]

Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-20588) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States]
 
Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States]
 
Limited Pilot for National Institute of General Medical Sciences Legacy Community-Wide Scientific Resources (R24) (PAR-10-261) [National Institute of General Medical Sciences, United States]
 
Submission for Office of Management and Budget Review; Comment Request; Resource for the Collection and Evaluation of Human Tissues and Cells from Donors With an Epidemiology Profile (NCI) (FR Doc. 2010-21098) [National Institutes of Health, United States]

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

9th Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

Symposium on Advanced Wound Care
September 23-25, 2010
Anaheim, United States

4th International Conference on Biofabrication
October 4-6, 2010
Philadelphia, United States

bone-tec 2010 – International Bone-Tissue-Engineering Congress
October 7-10, 2010
Hannover, Germany

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

BioStar 2010 – 4th Congress on Regenerative Biology and Medicine
October 13-15, 2010
Stuttgart, Germany

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

Translational Excellence in Regenerative Medicine – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

50th Anniversary American Society for Cell Biology Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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