Extracellular Matrix News Volume 1.19 | Sep 9 2010

Long-Term Human Pluripotent Stem Cell Self-Renewal on Synthetic Polymer Surfaces  

Derive iPSCs feeder-free* with mTeSR®1 by STEMCELL Technologies     *Sun et al., PNAS, September 2009. *Chan et al., Nature Biotechnology, October 2009.

How Physical Environment Influences Stem Cell Development
Research has revealed how physical qualities — and not only chemical ones — may have an influence in determining how adult stem cells from the bone marrow develop into differentiated ones. [Press release from ScienceDaily discussing online prepublication in Nature Physics]

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Optimal Matrix Rigidity for Stress-Fiber Polarization in Stem Cells
Researchers present a theoretical model and experiments demonstrating that the alignment of stress fibers within stem cells is a non-monotonic function of matrix rigidity. [Nat Phys]

The Restoration of Full-Thickness Cartilage Defects with BMSCs and TGF-Beta 1 Loaded PLGA/Fibrin Gel Constructs
Poly(lactide-co-glycolide) (PLGA) sponge was filled with fibrin gel, bone marrow mesenchymal stem cells (BMSCs) and transforming growth factor-beta1 (TGF-beta1) to obtain a construct for cartilage restoration in vivo. [Biomaterials]

Citric Acid-Derived In Situ Crosslinkable Biodegradable Polymers for Cell Delivery
The development of citric acid-derived injectable biodegradable poly(ethylene glycol) maleate citrate presents numerous opportunities for material innovation and offers excellent candidate materials for in situ tissue engineering and drug delivery applications. [Biomaterials]

Fluidic Microstructuring of Alginate Hydrogels for the Single Cell Niche
Controlling alginate gel formation by diffusion of Ca(2+) ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell, offers the possibility of exposing cells under biocompatible conditions to microheterogeneous three-dimensional environments, mimicking the layered structure of extracellular matrix in tissues. [Lab Chip]

Fibronectin Growth Factor-Binding Domains Are Required for Fibroblast Survival
Fibroblast survival required growth factor stimulation in the presence of a fibronectin (FN)-growth factor-binding domain, as well as adhesion to FN through the central cell-binding domain. [J Invest Dermatol]

Pellet Culture Model for Human Primary Osteoblasts
Researchers conclude that the transformation of the osteoblast phenotype in vitro to a more mature stage can be achieved more rapidly in 3D culture. [Eur Cell Mater]
 
Diffusion of Particles in the Extracellular Matrix: The Effect of Repulsive Electrostatic Interactions
Researchers present a mathematical framework to study the effect of charge on the diffusive transport of macromolecules and nanoparticles in the extracellular matrix of biological tissues. [Biophys J]

Triplex Forming Oligonucleotides Against Type Alpha 1(I) Collagen Attenuates Liver Fibrosis Induced by Bile Duct Ligation
Results suggests that triplex forming oligonucleotide can be used to downregulate type 1 collagen gene expression and can alleviate liver fibrosis induced by common bile duct ligation. [Biochem Pharmacol]

Fibronectin and Vitronectin Induce AP-1-Mediated Matrix Metalloproteinase-9 Expression Through Integrin Alpha(5)Beta(1)/Alpha(v)Beta(3)-Dependent Akt, ERK and JNK Signaling Pathways in Human Umbilical Vein Endothelial Cells
Data suggest that both fibronectin and vitronectin induce matrix metalloproteinase-9 expression via the AP-1-activating signaling pathways in endothelial cells, and thereby stimulate degradation of surrounding collagen, leading to alterations in extracellular matrix structure and potentially the promotion of angiogenesis. [Cell Signal]

The Density of Extracellular Matrix Proteins Regulates Inflammation and Insulin Signaling in Adipocytes
Researchers found that high density extracellular matrix causes a decrease in insulin signaling and adiponectin secretion, whereas the secretion of monocyte chemoattractant protein-1 was increased via the activation of nuclear factor-kappaB. [FEBS Lett]

Pfizer to Acquire FoldRx Pharmaceuticals
Pfizer Inc. and FoldRx Pharmaceuticals, Inc. announced that they have entered into an agreement under which Pfizer will acquire FoldRx. [FoldRx Pharmaceuticals, Inc. Press Release]

Forbion Capital Partners Raises EUR190 Million for New Investments
Forbion Capital Partners, a leading investment firm dedicated to the life science sector, announced the final closings of both FCF I Co-Invest Fund and of FCF II, raising a total of more than EUR190 million ($240 million). [Forbion Capital Partners Press Release]

Health Science Center Lands $11.6 Million to Study Cardiac Proteins
A blood test to diagnose which heart attack survivors will suffer heart failure is the goal of a new five-year, $11.6 million contract to the University of Texas Health Science Center San Antonio from the National Heart, Lung and Blood Institute. [University of Texas Health Science Center San Antonio Press Release]

Actavis Plans to Enter into Biosimilars
Actavis Group announced that it plans to enter into the field of biosimilars. [Actavis Group Press Release]
 
Halozyme Therapeutics Announces Public Offering of Common Stock
Halozyme Therapeutics, Inc. announced that it is offering to sell 8.3 million shares of its common stock pursuant to an effective shelf registration statement in an underwritten public offering. [Halozyme Therapeutics, Inc. Press Release]

Cell Therapy Foundation Calls for Additional Research, Extensive Clinical Trials
Some of the most promising medical research conducted to treat diseases of the brain, heart, and circulatory system is moving too slowly to help millions of patients, according to the Cell Therapy Foundation, which advocates the use of adult stem cells to dramatically impact and improve the condition of patients who suffer from a variety of conditions. [PR Newswire]

Judge Upholds Stem Cell Funding Ban
A Washington, D.C., judge said that his ruling, halting all federal funding for human embryonic stem cell research, will stand while the case moves forward. Chief Judge Royce Lamberth, responding to a request from the Department of Justice that he stay his preliminary injunction, released a 3-page order denying the request. [United States District Court for the District of Columbia]
 
FDA Launches New Organizational Performance Management System
The U.S. Food and Drug Administration (FDA) launched an innovative performance management system designed to advance the President’s commitment to transparency, public participation, and collaboration in the work of government. [Food and Drug Administration, United States]
 
Medical School Leaders Express Support for Stem Cell Research in New AAMC Ad [Association of American Medical Colleges, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-22096) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-22128) [National Institutes of Health, United States]
 
Center for Scientific Review; Amended Notice of Meeting (FR Doc. C1-2010-22119) [National Institutes of Health, United States]
 
Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting (FR Doc. 2010-22107) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-22093) [National Institutes of Health, United States]
 
National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States]

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

9th Annual Human Proteome Organization (HUPO) World Congress
September 19-23, 2010
Sydney, Australia

NEW Third Annual Maryland Stem Cell Research Symposium
September 22, 2010
Gaithersburg, United States

Symposium on Advanced Wound Care
September 23-25, 2010
Anaheim, United States

4th International Conference on Biofabrication
October 4-6, 2010
Philadelphia, United States

bone-tec 2010 – International Bone-Tissue-Engineering Congress
October 7-10, 2010
Hannover, Germany

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

BioStar 2010 – 4th Congress on Regenerative Biology and Medicine
October 13-15, 2010
Stuttgart, Germany

American Society for Matrix Biology (ASMB) 2010 Biennial Meeting
October 24-27, 2010
Charleston, United States

Select Biosciences 2nd Annual Lab-on-a-Chip World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

Medica 2010
November 17-20, 2010
Dusseldorf, Germany

Translational Excellence in Regenerative Medicine – Biophysical Stimuli and Mass Transport for Tissue Development
November 18-19, 2010
Lattrop, The Netherlands

First Berlin-Brandenburg School for Regenerative Therapies (BSRT) PhD Symposium
December 1-3, 2010
Berlin, Germany

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

50th Anniversary American Society for Cell Biology Annual Meeting
December 11-15, 2010
Philadelphia, United States

Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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