Extracellular Matrix News Volume 1.30 | Dec 2 2010

Restoration of Senescent Human Diploid Fibroblasts by Modulation of the Extracellular Matrix  
Researchers report that interaction with extracellular matrix from young cells is sufficient to restore aged, senescent cells to an apparently youthful state. [ Aging Cell]

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Transplantation of Human Fetal Blood Stem Cells in the Osteogenesis Imperfecta Mouse Leads to Improvement in Multi-Scale Tissue Properties
Expression of normal collagen from mature osteoblast of donor origin significantly decreased bone brittleness by improving the mechanical integrity of the bone at the molecular, tissue, and whole bone level. [Blood]
 
Cell Infiltration and Growth in a Low Density, Uncompressed Three-Dimensional Electrospun Nanofibrous Scaffold
Researchers have developed a three-dimensional cotton ball-like electrospun scaffold that consists of an accumulation of nanofibers in a low density and uncompressed manner. [Biomaterials]

Integration of Multiple Cell-Matrix Interactions into Alginate Scaffolds for Promoting Cardiac Tissue Regeneration
Researchers explored the possible role of a combination of two matrix-attached peptides, the adhesion peptide G₄RGDY and heparin-binding peptide G₄SPPRRARVTY, in cardiac tissue regeneration. [Biomaterials]
 
The Effect of Elastin on Chondrocyte Adhesion and Proliferation on Poly (Epsilon-Caprolactone)/Elastin Composites
Results demonstrate the potential of using poly (epsilon-caprolactone)/elastin composites for cartilage repair. [Biomaterials]

Laminins, via Heparan Sulfate Proteoglycans, Participate in Zebrafish Myotome Morphogenesis by Modulating the Pattern of Bmp Responsiveness
Results show that laminins, via heparan sulfate proteoglycans, are instrumental in patterning Bmp responsiveness and that Bmp signaling restricts Engrailed expression to the central domain. [Development]
 
Dymeclin, the Gene Underlying Dyggve-Melchior-Clausen Syndrome, Encodes a Protein Integral to Extracellular Matrix and Golgi Organization and Is Associated with Protein Secretion Pathways Critical in Bone Development
Data identify the role of Dymeclin in secretory pathways essential to endochondral bone formation during early development. [Hum Mutat]
 
The Kinesin KIF9 and Reggie/Flotillin Proteins Regulate Matrix Degradation by Macrophage Podosomes
Researchers identify the kinesin KIF9 and reggie/flotillin proteins as novel regulators of macrophage podosomes and show that their interaction is critical for the matrix-degrading ability of these structures. [Mol Biol Cell]
 
Altered Oxidative Stress Responses and Increased Type I Collagen Expression in Bicuspid Aortic Valve Patients
Data support the hypothesis that bicuspid aortic valve smooth muscle cells lack sufficient resistance to reactive oxygen species to maintain extracellular matrix homeostasis, which imparts a predisposition to thoracic aortic aneurysms. [Ann Thorac Surg]
 
‘Young’ Oral Fibroblasts Are Geno/Phenotypically Distinct
Researchers conclude that oral mucosal fibroblasts exhibit a preferential healing response in vivo, due to their ‘replicatively younger’ phenotype when compared with that of patient-matched skin fibroblasts. [J Dent Res]

Attachment to Extracellular Matrices Is Enhanced in Human Endometriotic Stromal Cells: A Possible Mechanism Underlying the Pathogenesis of Endometriosis
Adhesive properties of endometriotic stromal cells and normal eutopic endometrial cells to various extracellular matrix proteins were investigated by in vitro cell adhesion assays. [Eur J Obstet Gynecol Reprod Biol]

Halozyme Therapeutics to Present at Upcoming Investor Conference
Halozyme Therapeutics, Inc. announced that management will be presenting at the 5th Annual Canaccord Genuity Cardiovascular, Diabetes and Obesity Conference. [Halozyme Therapeutics, Inc. Press Release]
 
Growth Review Highlights Life Sciences as a Key Sector; Confirms Introduction of Patent Box and Reviews R&D Tax Credits
The government’s growth review “The path to strong, sustainable and balanced growth”, launched by the Chancellor of the Exchequer, George Osborne, is a promising road map to enable the UK to build its vibrant life sciences sector. [The Association of the British Pharmaceutical Industry Press Release]
 
New International Competition Focuses on Early Career Scientists
The Howard Hughes Medical Institute launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents with the goal of helping these talented individuals establish independent research programs. [Howard Hughes Medical Institute Press Release]

FDA and Life Sciences Industry Relationship Is Complicated by New Science and Changing Expectations, Finds PwC Survey
Growing public demand for increased medical device and drug safety, as well as the need to develop medical products faster, is complicating the current regulatory approval process and relationship between the life sciences industry and its chief regulator, the U.S. Food and Drug Administration, according to a new PricewaterhouseCoopers (PwC) report. [Food and Drug Administration, United States]

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