CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Degradable Polyester Scaffolds with Controlled Surface Chemistry Combining Minimal Protein Adsorption with Specific Bioactivation Researchers present a one-step preparation of fully synthetic, bioactive and degradable extracellular matrix-mimetic scaffolds by electrospinning, using poly(D,L-lactide-co-glycolide) as the matrix polymer. [Nat Mater] Active Scaffolds for On-Demand Drug and Cell Delivery Researchers present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. [Proc Natl Acad Sci U S A] Engineered Silk Fibroin Protein 3D Matrices for In Vitro Tumor Model Antheraea mylitta silk fibroin protein matrices were investigated as potential biomaterial for in vitro tumor modeling. [Biomaterials] Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Scaffolds That Is Independent of Myosin-Based Cytoskeletal Tension Researchers report on the effect of 3D matrix modulus on human bone marrow stromal cell differentiation. [Biomaterials] Endothelin-1 Increases Collagen Accumulation in Renal Mesangial Cells by Stimulating a Chemokine and Cytokine Autocrine Signaling Loop Researchers analyzed the gene expression profile of endothelin-1-stimulated mesangial cells to identify determinants of collagen accumulation. [J Biol Chem] Differential Effect of ECM Molecules on Re-Expression of Cartilaginous Markers in Near Quiescent Human Chondrocytes The objective of this study was to establish the beneficial effect of extracellular matrix (ECM) molecules on restoring the re-expression of cartilaginous markers in primary human chondrocytes after extensive monolayer expansion. [J Cell Physiol] Effects of Extracellular Matrix Density and Mesenchymal Stem Cells on Neovascularization In Vivo Researchers previously established that increasing extracellular matrix density inhibits capillary morphogenesis in three-dimensional tissues in vitro, and that addition of human mesenchymal stem cells partially rescues a healthy angiogenic phenotype. This study’s goal was to investigate if these effects can be recapitulated in vivo. [Tissue Eng Part A ] Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions Findings demonstrate that mouse embryonic stem cell self-renewal and pluripotency can be maintained homogeneously on soft substrates via the biophysical mechanism of facilitating generation of low cell-matrix tractions. [PLoS One] 3 Hours of Perfusion Culture Prior to 28 Days of Static Culture, Enhances Osteogenesis by Human Cells in a Collagen GAG Scaffold This study examined the effect of short term flow perfusion bioreactor culture, prior to long term static culture, on human osteoblast cell distribution and osteogenesis within a collagen glycosaminoglycan (GAG) scaffold for bone tissue engineering. [Biotechnol Bioeng] Influence of Substrate Stiffness on Cell-Substrate Interfacial Adhesion and Spreading: A Mechano-Chemical Coupling Model Based on the classical Bell-Dembo’s theory, this paper develops a mechano-chemical coupling model to physically describe cell adhesion and spreading mediated by substrate stiffness. [J Colloid Interface Sci] HGF Inhibits TGF-Beta1-Induced Myofibroblast Differentiation and Extracellular Matrix Deposition via MMP-2 in Achilles Tendon in Rat Results indicate hepatocyte growth factor (HGF) attenuates TGF-beta1-induced fibrogenic responses in Achilles tendon, which was mediated by matrix metalloproteinase (MMP)-2. [Eur J Appl Physiol]
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