Extracellular Matrix News Volume 10.38 | Oct 3 2019

TOP STORY

Engineered Fibrillar Fibronectin Networks as Three-Dimensional Tissue Scaffolds

The cell-free and scalable synthesis of freely suspended and mechanically robust three-dimensional networks of fibrillar fibronectin supported by tessellated polymer scaffolds was reported. [Adv Mater] Abstract | Press Release

(Ranked by impact factor of the journal)

Zinc-Doped Prussian Blue Enhances Photothermal Clearance of Staphylococcus aureus and Promotes Tissue Repair in Infected Wounds

Researchers developed an exogenous antibacterial agent consisting of zinc-doped Prussian blue that kills methicillin-resistant Staphylococcus aureus in vitro and in a rat model of cutaneous wound infection. [Nat Commun] Full Article

Connective Tissue Fibroblasts from Highly Regenerative Mammals Are Refractory to ROS-Induced Cellular Senescence

While H₂O₂ exposure substantially decreased cell proliferation and increased p53, p21, p16, and p19 in cells from mice and rats, cells from spiny mice and rabbits were highly resistant to H₂O₂. [Nat Commun] Full Article | Press Release

Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction

Scientists report an injectable, citrate-containing polyester hydrogel, which could release citrate as a cell regulator via hydrogel degradation and simultaneously showed sustained release of an encapsulated growth factor Mydgf. [ACS Appl Mater Interfaces] Abstract

BK Ablation Attenuates Osteoblast Bone Formation via Integrin Pathway

The authors report that big conductance calcium-activated potassium channels (BKs) were required for bone formation and osteoblast function both in vivo and in vitro. Mechanistically, BK ablation in bone and bone marrow mesenchymal stem cells of BK knockout mice inhibited integrin signaling. [Cell Death Dis] Full Article

Phlpp1 Is Associated with Human Intervertebral Disc Degeneration and Its Deficiency Promotes Healing after Needle Puncture Injury in Mice

In human intervertebral discs (IVDs), PH domain leucine-rich repeat protein phosphatase (Phlpp1) expression was positively correlated with IVD degeneration (IDD) and the apoptosis marker cleaved Caspase-3, suggesting a key role of Phlpp1 in the progression of IDD. [Cell Death Dis] Full Article

Chimeric Antigen Receptor Macrophage Therapy for Breast Tumors Mediated by Targeting the Tumor Extracellular Matrix

Investigators modified macrophages with a designed chimeric antigen receptor, which could be activated after recognition of the tumor antigen HER2 to trigger the internal signaling of CD147 and increase the expression of matrix metalloproteinases. [Br J Cancer] Abstract

Longer Collagen Fibers Trigger Multicellular Streaming on Soft Substrates via Enhanced Forces and Cell-Cell Cooperation

Researchers developed new hydrogels and discovered invasion-like streaming of normal epithelial cells on soft substrates coated with long collagen fibers. Streams arose owing to a surge in cell velocities, forces, YAP activity and expression of mesenchymal marker proteins in regions of high-stress anisotropy. [J Cell Sci] Abstract | Press Release

Perimysial Microarteriopathy in Dermatomyositis with Anti-Nuclear Matrix Protein-2 Antibodies

Immunofluorescence assays were performed to localize endothelial cells, smooth muscle cells and pericytes, and to determine lesions in myofibers and microvessels by vascular endothelial growth factor and myxovirus resistance protein A. [Eur J Neurol] Abstract

Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News.

Mechanisms of 3D Cell Migration

The authors examine how cells use both classical and novel mechanisms of locomotion as they traverse challenging 3D matrices and cellular environments. [Nat Rev Mol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Exogenesis Corporation Receives 510(k) Clearance for the Exogenesis Hernia Mesh, First Soft Tissue Repair Device with Nano-Modified Surface

Exogenesis Corporation announced that it received premarket clearance of a 510(k) application by the FDA for the Exogenesis Hernia Mesh, an innovative implant intended for soft tissue repair. [Exogenesis Corporation (PR Newswire Association LLC)] Press Release

UW-Madison, Local Startup Testing a One-Two Punch against Hard-to-Heal Wounds

A $1.5 million, two-year Small Business Innovation Research grant will test whether adding gallium metal ions to an ultra-thin material carrying antimicrobial silver can defeat the “biofilms” that shield bacteria from antibiotics. [University of Wisconsin-Madison] Press Release

Split Decisions: How Brexit Has Taken a Toll on Five Researchers

On 23 June 2016, 34 million UK citizens took to the polls to vote on a simple, fateful question: Should the United Kingdom remain a part of the European Union, or should it leave? Nearly 52%—a majority of 1.3 million—wanted out, and conservative politicians vowed to carry out the people’s wishes. [ScienceInsider] Editorial

‘There’s No Taboo, No Bad Ideas’: Anyone Can Help Shape European Union’s New €94 Billion Research Program

These encouraging words were spoken here last week at the European Research and Innovation Days, where policy bigwigs working with the European Commission invited the audience to help shape Europe’s next seven-year research funding program, Horizon Europe, set to begin in 2021. Their message: Anyone can help “cocreate” the program’s outlines. [ScienceMagazine] Editorial

NEW ISSCR 2020 Stem Cells and Regenerative Medicine
March 13-15, 2020
Shanghai, China

Visit our events page to see a complete list of events in the community.

NEW Research Associate – Protein Structural Biology (University of Manchester)

NEW Postdoctoral Fellowship – Cell and Developmental Biology (Fred Hutchinson Cancer Research Center)

Scientist – Matrix Biology (STEMCELL Technologies Inc.)

PhD Student – Receptor-Independent Signaling (University Hospital of Muenster)

Postdoctoral Research Scientist – Tumor Microenvironment and Proteomics (Cancer Research UK Beatson Institute)

Postdoctoral Fellow – Wound Healing (University of Pennsylvania)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Postdoctoral Researchers – Engineering Human Tissues (Columbia University)

Postdoctoral Researcher – Molecular Mechanisms of Psychiatric Disorders (McLean Hospital)

Postdoctoral Position – Receptor Biology (Scripps Research Institute)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or suggestions? Submit your feedback here.