Extracellular Matrix News Volume 10.40 | Oct 17 2019

TOP STORY

Migratory DCs Activate TGF-β to Precondition Naïve CD8⁺ T Cells for Tissue-Resident Memory Fate

Researchers showed that during immune homeostasis, the cytokine transforming growth factor β (TGF-β) epigenetically conditioned resting naïve CD8⁺ T cells and prepared them for the formation of epithelial resident memory T cells in a mouse model of skin vaccination. [Science] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Solid Matrix-Assisted Printing for Three-Dimensional Structuring of a Viscoelastic Medium Surface

Scientists report solid matrix-assisted 3D printing of an incubation medium surface and the 3D fabrication of bacterial cellulose hydrogels by in situ biosynthesis of Gluconacetobacter xylinus. [Nat Commun] Full Article

In Vivo Engineered Extracellular Matrix Scaffolds with Instructive Niches for Oriented Tissue Regeneration

Investigators engineered ECM scaffolds with parallel microchannels by subcutaneous implantation of sacrificial templates, followed by template removal and decellularization. They demonstrated the versatility and flexibility of these scaffolds by regenerating vascularized and innervated neo-muscle, vascularized neo-nerve and pulsatile neo-artery with functional integration. [Nat Commun] Full Article

MatrisomeDB: The ECM-Protein Knowledge Database

The authors present a new release of MatrisomeDB, a searchable collection of curated proteomic data from 17 studies on the ECM of 15 different normal tissue types, six cancer types (different grades of breast cancers, colorectal cancer, melanoma, and insulinoma) and other diseases including vascular defects and lung and liver fibroses. [Nucleic Acids Res] Full Article

The Interplay between Chondrocyte Spheroids and Mesenchymal Stem Cells Boosts Cartilage Regeneration within a 3D Natural-Based Hydrogel

A thermo-sensitive chitosan-based hydrogel, ionically crosslinked with β-glycerophosphate, was optimized to obtain sol/gel transition at physiological conditions within five minutes, high porosity with pores diameter <30 µm, and in vitro mechanical integrity with compressive and equilibrium Young’s moduli of 37 kPa and 17 kPa, respectively. [Sci Rep] Full Article

The Impact of Decellularization Methods on Extracellular Matrix Derived Hydrogels

Researchers examined the impact of decellularization protocols in ECM-derived hydrogels obtained from porcine corneas. Porcine corneas were isolated and decellularized with SDS, Triton X-100 or by freeze-thaw cycles. [Sci Rep] Full Article

Gene Expression Profiling of the Extracellular Matrix Signature in Macrophages of Different Activation Status: Relevance for Skin Wound Healing

Among core matrisome and matrisome-associated components transforming growth factor beta-induced, matrix metalloproteinase 9, elastin microfibril interfacer-1, netrin-1 and gliomedin were present within the wound bed at time points that were characterized by profound macrophage infiltration. [Int J Mol Sci] Full Article | Graphical Abstract

Acellular PCL Scaffolds Laden with Fibroblast/Endothelial Cell-Derived Extracellular Matrix for Bone Regeneration

Successive culture and decellularization of fibroblasts and endothelial cells grown on polycaprolactone microfibers was used to develop a bioactive scaffold with heterogeneous decellularized ECM mimicking endothelial basement membrane. [J Biomed Mater Res A] Abstract

Extracellular Matrix Deposition by Adipose-Derived Stem Cells and Fibroblasts: A Comparative Study

Adipose-derived stem cells (ADSCs) turned out to be capable of efficiently producing a collagen and fibronectin-containing dermal matrix upon stimulation with ascorbic acid. Scientists observed fibronectin and collagen production by ADSCs to be even more abundant when compared to fibroblasts’. [Arch Dermatol Res] Abstract

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Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior

The authors discuss innovative materials currently being used to study tumor and immune cell behavior and interactions, including materials that mimic ECM composition, mechanical stiffness, and integrin binding sites of the tumor microenvironment. [Ann Biomed Eng] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

First Application of Genetically Modified, Live-Cell, Pig Skin to a Human Wound

Burn specialists at Massachusetts General Hospital (MGH) announced they have successfully used live-cell, genetically engineered pig skin for the temporary closure of a burn wound. [Massachusetts General Hospital (EurekAlert!)] Press Release

University of Oklahoma Scholar Awarded Astronaut Scholarship

Emily Thomas, a junior biomedical engineering major in the Gallogly College of Engineering, was named a member of the 2019 Astronaut Scholar Class. Thomas is one of 52 scholars from 38 universities across the nation to receive the prestigious $10,000 scholarship from the Astronaut Scholarship Foundation. [University of Oklahoma (Newswise, Inc.)] Press Release

$3 Billion Ballot Proposition Will Decide Fate of Texas Cancer Research Funding Agency

On 5 November, Texas residents will decide whether to sustain CPRIT, the second largest public source of cancer funding in the United States after the federal government. At stake is its generous support for 123 tenure-track faculty like Francesca Cole, who investigates cancer and DNA repair. [ScienceMagazine] Editorial

Indian Government Tightens Rules on Academic Collaboration with China

India is tightening the rules for academic collaborations with its neighbor and main rival, China. Under a new policy, universities and research institutes must seek permission from the ministries of Home Affairs and External Affairs before signing a collaboration agreement or memorandum of understanding with a Chinese institution. [ScienceMagazine] Editorial

NEW Molecular Mechanisms of Electrical Signaling in Health and Disease
July 12-17, 2020
South Hadley, Massacheussetts, United States

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NEW Postdoctoral Fellowship – Metabolism, Signaling, and Epigenetics (University of California, Irvine)

Scientist – Matrix Biology (STEMCELL Technologies Inc.)

PhD Candidate – Retinal Pigment Epithelium (RWTH Aachen University)

Postdoctoral Scholarship – Cancer Biology (Lund University)

Research Associate – Protein Structural Biology (University of Manchester)

Postdoctoral Fellowship – Cell and Developmental Biology (Fred Hutchinson Cancer Research Center)

PhD Student – Receptor-Independent Signaling (University Hospital of Muenster)

Postdoctoral Fellow – Wound Healing (University of Pennsylvania)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Postdoctoral Researchers – Engineering Human Tissues (Columbia University)

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