Extracellular Matrix News Volume 10.43 | Nov 7 2019

TOP STORY

Osteocyte Dysfunction Promotes Osteoarthritis through MMP13-Dependent Suppression of Subchondral Bone Homeostasis

Suppression of osteocyte perilacunar/canalicular remodeling was most severe in the medial compartment of osteoarthritis subchondral bone, with lower protease expression, diminished canalicular networks, and disorganized and hypermineralized ECM. [Bone Res] Full Article | Press Release

(Ranked by impact factor of the journal)

Epithelial CD47 Is Critical for Mucosal Repair in the Murine Intestine In Vivo

The authors showed that normal mice treated with anti-CD47 antibodies, and Cd47-null mice had impaired intestinal mucosal wound healing. Defective wound repair after CD47 loss was linked to decreased epithelial β1 integrin and focal adhesion signaling, as well as reduced thrombospondin-1 and TGF-β1. [Nat Commun] Full Article

Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling

Pharmacologic and genetic inhibition of protein kinase D1 (Prkd1) in the Twist1-induced dissemination model demonstrated that Prkd1 was required for cells to initiate ECM-directed protrusions, release from the epithelium, and migrate through the extracellular matrix. [Cancer Res] Abstract

Interaction between Laminin-5γ2 and Integrin β1 Promotes the Tumor Budding of Colorectal Cancer via the Activation of Yes-Associated Proteins

Investigators observed the interaction of integrin with extracellular matrix components, laminin-5γ2 (LN-5γ2), played essential roles in the tumor budding (TB) of colorectal cancer (CRC). They then verified that the interaction between LN-5γ2 and integrin β1 promoted the TB of CRC via the activation of FAK and Yes-associated proteins. [Oncogene] Abstract

SPARCL1 Promotes C2C12 Cell Differentiation via BMP7-Mediated BMP/TGF-β Cell Signaling Pathway

The results of western blotting and immunofluorescence showed that SPARCL1 was associated with the repair of muscle damage in mice and that SPARCL1 bound to bone morphogenetic protein 7 (BMP7) by regulating BMP/transforming growth factor (TGF)-β cell signaling. [Cell Death Dis] Full Article

CRISPR Interference to Interrogate Genes That Control Biofilm Formation in Pseudomonas fluorescens

Combined with detailed confocal microscopy of biofilms, scientists revealed novel phenotypes associated with ECM biosynthesis as well as the potent inhibition of SBW25 biofilm formation mediated by the PFLU1114 operon. [Sci Rep] Full Article

Serpent/dGATAb Regulates Laminin B1 and Laminin B2 Expression during Drosophila Embryogenesis

Researchers demonstrated direct binding of Serpent to the intronic enhancers of Laminin B1 and Laminin B2. In addition, ectopically expressed Serpent activated enhancer elements of Laminin B1 and Laminin B2. [Sci Rep] Full Article

Growth Factors with Enhanced Syndecan Binding Generate Tonic Signaling and Promote Tissue Healing

Scientists showed that vascular endothelial growth factor-A and platelet-derived growth factor-BB that were engineered to have a syndecan-binding sequence trigger sustained low-intensity signaling and reduced the desensitization of growth factor receptors. [Nat Biomed Eng] Abstract

Cell-Free Fat Extract Increases Dermal Thickness by Enhancing Angiogenesis and Extracellular Matrix Production in Nude Mice

Cell-free fat extract (Ceffe) significantly increased cell proliferation in cultured dermal fibroblasts. In mouse skin, Ceffe significantly increased the thickness of the dermis, number of proliferating cells, density of the capillary, and expressions of type I and III collagen. [Aesthet Surg J] Abstract

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Multifaceted Roles of TAK1 Signaling in Cancer

The authors present a comprehensive review of TAK1 signaling and provide important therapeutic perspectives related to its function in different cancers. [Oncogene] Abstract

Raman Spectroscopy: Guiding Light for the Extracellular Matrix

Investigators review Raman spectroscopy techniques for ECM characterizations over a variety of exciting applications and tissue systems, including native tissue assessments, regenerative medicine quality assessments, and diagnostics of disease states. [Front Bioeng Biotechnol] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Karolinska Development’s Portfolio Company OssDsign Reports Favourable Outcome Data on OSSDSIGN Cranial PSI

Karolinska Development announced that its portfolio company OssDsign has released updated outcome data which reveals that the rate of infections leading to implant removal of OSSDSIGN Cranial PSI remained low after a median follow-up time of 17 months. [Karolinska Development] Press Release

Engitix Receives a Golden Ticket to Labcentral from Takeda to Advance Fibrosis and Solid Tumour Research

Engitix Ltd. announced that its subsidiary Engitix, Inc. has been awarded a Golden Ticket to LabCentral by Takeda Pharmaceutical Company Limited. The Golden Ticket provides Engitix one year of lab bench space at LabCentral, a world-class shared laboratory and office space in Cambridge, Massachusetts. [Engitix Ltd.] Press Release

Texas Voters Approve Second Life for State Cancer Funding Agency

On 5 November, Texas voters approved (64% to 36%) a ballot measure to extend the life of its pioneering state cancer research funding agency, CPRIT, by doubling, to $6 billion, the amount of bonds that can be issued to support the agency. [ScienceInsider] Editorial

South Korea Clamps Down on Academics Attending ‘Weak’ Conferences

South Korea’s education ministry wants to stop academics from participating in conferences that it considers “weak” and of little academic value. The ministry announced on 17 October that it will require all universities to adopt measures to vet academics’ travel to overseas conferences so as to “prevent researchers from engaging in poor academic activities”. [Nature News] Editorial

NEW Gordon Research Conference: Frontiers in Basic and Translational Proteoglycan Research to Improve Human Health
July 12-17, 2020
Andover, New Hampshire, United States

Visit our events page to see a complete list of events in the community.

NEW Lecturers – Bioengineering (Imperial College London)

Postdoctoral Research Fellowship – Cartilage Mechanobiology (KU Leuven)

Postdoctoral Researcher – Islet Biology, Stem Cells, and Regenerative Medicine (Geneva University)

Faculty Position – Bone Biology and Regenerative Medicine (University of Michigan)

Postdoctoral Fellowship – Metabolism, Signaling, and Epigenetics (University of California, Irvine)

PhD Candidate – Retinal Pigment Epithelium (RWTH Aachen University)

PhD Student – Receptor-Independent Signaling (University Hospital of Muenster)

Postdoctoral Fellow – Wound Healing (University of Pennsylvania)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Postdoctoral Researchers – Engineering Human Tissues (Columbia University)

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