Extracellular Matrix News 10.45 November 21, 2019 | |
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TOP STORYTailoring Cryo-Electron Microscopy Grids by Photo-Micropatterning for In-Cell Structural Studies Researchers described contactless and mask-free photo-micropatterning of electron microscopy grids for site-specific deposition of ECM-related proteins. They attained refined cell positioning for micromachining by cryo-focused ion beam milling. [Nat Methods] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)A Novel Dual-Adhesive and Bioactive Hydrogel Activated by Bioglass for Wound Healing Bioglass endows the hydrogel with adhesiveness to implantable materials by releasing Ca ions, which might chelate with the carboxyl groups of the hydrogel matrix. In addition, the composite hydrogel showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. [NPG Asia Mater] Full Article Scientists found that H1 histamine receptor was frequently unregulated in hepatocellular carcinoma (HCC), which was significantly associated with both recurrence-free survival and overall survival in HCC patients. [Oncogene] Full Article HIC-5 in Cancer-Associated Fibroblasts Contributes to Esophageal Squamous Cell Carcinoma Progression Investigators isolated primary cancer-associated fibroblasts (CAFs) and normal fibroblasts from esophageal squamous cell carcinoma (ESCC) patients. Hydrogen peroxide-inducible clone 5 (HIC-5) was highly expressed in CAFs from the tumor stroma of human ESCC patients. [Cell Death Dis] Full Article RUNX1 Contributes to the Mesenchymal Subtype of Glioblastoma in a TGFβ Pathway-Dependent Manner The authors showed that Runt-Related Transcription Factor 1 (RUNX1) was upregulated in mesenchymal glioblastoma (GBM) cell lines, tissues and patients and promoted proliferation and invasion in GBM in a TGFβ pathway-dependent manner in vivo and in vitro. [Cell Death Dis] Full Article Scientists showed that Yes-associated protein (YAP) co-localized with F-actin during activating conditions, such as sparse plating and culturing on stiff 2D substrates. To identify proteins mediating YAP translocation, they performed co-immunoprecipitation followed by mass spectrometry for proteins that differentially associated with YAP under activating conditions. [Sci Rep] Full Article Investigators showed that growth of epithelial cancers induced compressive remodeling of the ECM, documented in the literature as a TACS-2 phenotype, which represented a localized densification and tangential alignment of peri-tumoral collagen. [Sci Rep] Full Article TGF-β1 Activates RSC96 Schwann Cells Migration and Invasion through MMP-2 and MMP-9 Activities Researchers investigated the cellular effects and the signal transduction pathways evoked by TGF-β1 in Rattus norvegicus neuronal Schwann RSC96 cells. TGF-β1 significantly increased migration and invasion of Schwann cells assessed by wound-healing assay and by cell invasion assay. [J Neurochem] Abstract Tubular Injury Triggers Podocyte Dysfunction by β-Catenin-Driven Release of MMP7 Matrix metalloproteinase-7 (MMP-7), a downstream target of β-catenin, was upregulated in treated control mice, but this induction was blunted in the Ksp-β-cat-/- littermates. Incubation of isolated glomeruli with MMP-7 ex vivo led to nephrin depletion and impaired glomerular permeability. [JCI Insight] Abstract | Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSControlling Immunity and Inflammation through Integrin-Dependent Regulation of TGF-β The authors review the spatiotemporal control of TGF-β activation by integrins, and its effects on immune cell signaling and function. They discuss the underlying molecular and cell-biological mechanisms, the implications for human health and disease, and possibilities for future therapeutic exploitation. [Trends Cell Biol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSUS Capital Global Securities Launches $14 Million Impact Investment Offering for Smart Matrix Ltd Smart Matrix Ltd is developing Smart Matrix®, a next-generation wound-healing technology designed to treat full-thickness skin wounds by encouraging the growth of skin cells and new blood vessels, critical to healthy healing, all without a skin graft. [Smart Matrix, Ltd. (GlobeNewswire, Inc.)] Press Release | |
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POLICY NEWSScience Funders Gamble on Grant Lotteries The Health Research Council of New Zealand is one of a growing number of funders that award grants partly through random selection. Earlier this year, for example, David Ackerley, a biologist at Victoria University of Wellington, received NZ$150,000 (US$96,000) to develop new ways to eliminate cells – after his number came up in the council’s annual lottery. [Nature News] Editorial The Science Institutions Hiring Integrity Inspectors to Vet Their Papers Some researchers have their manuscripts screened for errors before they go to journals. [Nature News] Editorial
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EVENTSNEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Bioengineering Organoid Morphogenesis (KU Leuven) Research Associate – Models of Cancer (University of Nottingham) Lecturers – Bioengineering (Imperial College London) Postdoctoral Research Fellowship – Cartilage Mechanobiology (KU Leuven) Postdoctoral Researcher – Islet Biology, Stem Cells, and Regenerative Medicine (Geneva University) Faculty Position – Bone Biology and Regenerative Medicine (University of Michigan) Postdoctoral Fellowship – Metabolism, Signaling, and Epigenetics (University of California, Irvine) PhD Candidate – Retinal Pigment Epithelium (RWTH Aachen University) Postdoctoral Fellow – Wound Healing (University of Pennsylvania) Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University) Postdoctoral Researchers – Engineering Human Tissues (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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