Extracellular Matrix News 11.05 February 13, 2020 | |
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TOP STORYDefining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis Investigators found differing compositions of regulatory ECM components in the neurogenic niche. They showed that quiescent neural stem cells were the main source of their local ECM, including the multi-functional enzyme transglutaminase 2, which they showed was crucial for neurogenesis. [Cell Stem Cell] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists revealed that Rac1 inhibitor NSC23766 treatment promoted the expression of collagen II, aggrecan and Sox-9, and decreased the expression of ADAMTS5 and MMP13 in IL-1β-stimulated rat endplate chondrocytes (EPCs). They also found that NSC23766 could suppress the activation of Wnt/β-catenin pathway, suggesting that the beneficial effects of Rac1 inhibition in EPCs were mediated through the Wnt/β-catenin signaling. [J Cell Mol Med] Full Article Transglutaminase-2 Facilitates Extracellular Vesicle-Mediated Establishment of the Metastatic Niche Investigators utilized global gene expression analyses to characterize a metastatic model of epithelial-mesenchymal plasticity as compared to their non-metastatic counterparts. Using this approach, they demonstrated that upregulation of the ECM crosslinking enzyme tissue transglutaminase-2 was part of a novel gene signature that only emerged in metastatic cells that have undergone induction and reversion of epithelial-mesenchymal transition. [Oncogenesis] Full Article Carbon Nanotubes Promote Cell Migration in Hydrogels Carbon nanotube-glycol chitosan hydrogels were synthesized and studied. Chemoattractant-induced cell migration was studied using a modified Boyden Chamber experiment. Migrated cells were counted using flow cytometry. [Sci Rep] Full Article The authors investigated the effect of Matrigel combined with neural stem cells (NSCs) in vitro and in vivo. They compared the effect of different types of scaffold on the survival and differentiation of brain-derived NSCs in an in vitro culture. [Sci Rep] Full Article Three modules, which were enriched in T-cell immune, cel-cell adhesion and ECM, respectively, were found to be related to longer overall survival. Higher expression of several hub genes within these three co-expression modules, for example, LCP2,CD3D, FYB, GZMK, FN1, SPARC, were found to be associated with favorable survival. [Pharmacogenomics J] Abstract The authors hypothesized that low molecular weight (LMW) hyaluronan fragments contributed to female reproductive aging by stimulating an inflammatory response in the ovarian stroma and impairing gamete quality. To test this hypothesis, isolated mouse ovarian stromal cells or secondary stage ovarian follicles were treated with physiologically relevant concentrations of 200 kDa LMW hyaluronan. [Int J Mol Sci] Full Article Scientists investigated biological dermal templates and their potential to stimulate natural cell adherence, guidance, and morphology. The most pronounced effect was observed in biomaterials with the highest content of native collagen networks. Cell attachment and proliferation were significantly enhanced on native collagen scaffolds. [Int Wound J] Abstract The cell models used by investiators were primary human umbilical vein endothelial cells and a human dermal microvascular endothelial cell line. After siRNA- and shRNA-mediated knockdown of αII-spectrin, the authors assessed its expression and that of its partners and adhesion proteins using western blotting. The phenotypes of the control and spectrin-depleted cells were examined using immunofluorescence and video microscopy. [Cell Mol Biol Lett] Abstract The authors assessed effects of TGF-β on gene expression in C2C12 myoblasts and myotubes after 1, 3, 9, 24 and 48 hour treatment. In myoblasts, various myogenic genes were repressed after 9, 24 and 48 hours, while in myotubes only a reduction in Myh3 expression was observed. [Cells] Abstract | Download Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSCD8+ T Cell States in Human Cancer: Insights from Single-Cell Analysis Investigators cover current knowledge of the T cell states that are present in human tumors and the role that different T cell populations have been hypothesized to play within the tumor microenvironment, with a particular focus on CD8+ T cells. [Nat Rev Cancer] Abstract Integrin-Associated Molecules and Signaling Cross Talking in Osteoclast Cytoskeleton Regulation The authors discuss the role of integrin and associated molecules in osteoclastogenesis cytoskeletal, especially podosome, regulation and relevant signaling cascades cross talk. [J Cell Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWS$51 Million Federal Grant Awarded to ARMI Project The US Department of Health and Human Services is awarding a five-year, $51 million grant to the Advanced Regenerative Manufacturing Institute in Manchester to help it develop its Priority Medicines on Demand project. [US Department of Health and Human Services (NH Business Review)] Press Release Anseth Earns International Recognition with L’Oreal-UNESCO for Women in Science Award CU Boulder Professor Kristi Anseth has received one of the most prestigious recognitions in the life sciences: a L’Oreal-UNESCO for Women in Science award. Anseth, a professor in the Department of Chemical and Biological Engineering, is being recognized for her “outstanding contribution in converging engineering and biology to develop innovative biomaterials that help tissue regeneration and drug delivery.” [University of Colorado Boulder] Press Release | |
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POLICY NEWSPopular Preprint Servers Face Closure Because of Money Troubles The rise of preprint repositories has helped scientists worldwide to share results and get feedback quickly. But several platforms that serve researchers in emerging economies are struggling to raise money to stay afloat. Repositories like INA-Rxiv and IndiaRxiv boost regional science, but finding cash to run them is proving difficult. [Nature News] Editorial FDA Now Allows Certain Lab Animals to Be Retired and Adopted The US Food and Drug Administration will now permit certain animals used in experiments to retire and be adopted rather than face euthanasia, according to internal documents reviewed by The Hill. Although the policy changed in November, there have not been any public statements from the agency. [The Scientist] Editorial
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EVENTSNEW Diverse Organisms and Common Mechanisms in Cell-Cell Fusion Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Associate – Bioengineering (STEMCELL Technologies Inc.) Postdoctoral Fellow – Mechanisms of TGF-Beta Activiation (Genentech, Inc.) Postdoctoral Fellow – Extracellular Superoxide Dismutase (Vascular Biology Center) Postdoctoral Researcher – Computational Biology (Medical University of GdaÅ„sk) Research Associate – Oncology (Zymeworks, Inc.) Research Fellow – Cell Signaling (University of Sussex) Research Scientist – Tumor Microenvironment (Systimmune, Inc.) Postdoctoral Researcher – Tumor Microenvironment (Personalis, Inc.) Scientist – Regenerative Medicine (Xtant Medical, Inc.) Master Thesis – Hydrogels and Microfluid Environments (Karlsruhe Institute of Technology) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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