Extracellular Matrix News 11.08 March 5, 2020 | |
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TOP STORYResearchers found that fibroblast growth factor (FGF)9 signaled through epithelial FGF receptor 3 to directly promote distal epithelial fate specification and inhibit epithelial differentiation. [Sci Signal] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Hypoxia-Induced lncRNA PDIA3P1 Promotes Mesenchymal Transition via Sponging of miR-124-3p in Glioma Scientists found that protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) expression was closely related to tumor degree, transcriptome subtype, and prognosis in glioma patients. [Cell Death Dis] Full Article Investigators showed that human mesenchymal stromal cells (MSCs) secreted ECM proteins into the pericellular space early after encapsulation and that, even in the absence of material-presented cell adhesion motifs, cell-derived fibronectin enabled cell spreading. [Adv Healthc Mater] Abstract The authors compared the mostly applied pericardia in clinics, i.e. bovine and porcine tissues, after their decellularization, and obtained new insights for their possible surgical use. [Biomolecules] Full Article TGF-β2 induced the upregulation of epithelial-mesenchymal transformation markers including α-smooth muscle actin, Snail, and Slug and downregulation of E-cadherin in ARPE-19 cells. [Sci Rep] Full Article Scientists assessed mitochondrial damage and reactive oxygen species (ROS) formation as possible inducers of matrix-metalloproteinase (MMP)-13, and they analyzed MMP-13-dependent damage. [Sci Rep] Full Article Bioactive Glass (BG) ICIE16 Shows Promising Osteogenic Properties Compared to Crystallized 45S5-BG The influence of ICIE16-BG on viability, proliferation, and osteogenic differentiation of human mesenchymal stromal cells was evaluated in direct comparison to 45S5-BG. [Int J Mol Sci] Abstract | Full Article Researchers investigated whether the deletion of the integrin receptor α1 subunit influenced collagen and other matrix proteins in musculotendinous tissue and whether it caused any compensatory changes in other integrin subunits in C57BL/6J mice. [Cell Tissue Res] Abstract Investigators report a new method for maintaining cell viability and inducing cell migration using a perfused microfluidic platform based on collagen gel and a gradient hydrogel sheet. [Biomed Mater] Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSThe authors propose that a better interpretation of the central nervous system complexity can be granted by a systems biology approach through the construction of predictive molecular models that enlighten the regulatory logic of the complex molecular networks underlying brain function in health and disease, thus opening the way to more effective treatments. [Int J Mol Sci] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSSynedgen Announces $1 Million Award from Defense Health Agency to Develop SynePure and Catasyn Synedgen announced a combined $1 million award from the Defense Health Agency (DHA) Small Business Innovation Research Program (SBIR), along with additional research funds from the DHA, to commercialize its products, SynePureâ„¢ Wound Cleanser and Catasynâ„¢ Advanced Technology Wound Hydrogel, developed under DHA SBIR award W81XWH-16-C-0023. [Synedgen] Press Release AVITA Medical Limited announced the initiation of a pivotal study for soft tissue reconstruction with the enrollment of the first patient at the Arizona Burn Center at Valleywise Medical Health Center in Phoenix. [AVITA Medical Limited] Press Release | |
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POLICY NEWSChina Bans Cash Rewards for Publishing Papers Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial UC Santa Cruz Fires Graduate Students Taking Part in Strike The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial
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EVENTSNEW Gordon Research Conference: Diverse Organisms and Common Mechanisms in Cell-Cell Fusion Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Researcher – Myometrial ECM (University of Vermont) Investigator – Single Cell Genomics (GlaxoSmithKline USA) Researcher – Biomaterials Scientist (Aspect Biosystems) Postdoctoral Fellow – Mechanisms of TGF-Beta Activiation (Genentech, Inc.) Postdoctoral Fellow – Extracellular Superoxide Dismutase (Vascular Biology Center) Research Associate – Oncology (Zymeworks, Inc.) Research Scientist – Tumor Microenvironment (Systimmune, Inc.) Scientist – Regenerative Medicine (Xtant Medical, Inc.) Master Thesis – Hydrogels and Microfluid Environments (Karlsruhe Institute of Technology) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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