 | | Vol. 11.23 – 18 June, 2020 |
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| Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduced the risk of immune rejection associated with xenogeneic materials.
[Science Advances] |
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| The authors developed an in situ 3D printing system that estimated the motion and deformation of the target surface to adapt the toolpath in real time. With this printing system, a hydrogel-based sensor was printed on a porcine lung under respiration-induced deformation.
[Science Advances] |
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| Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists report a facile approach to generate ECM biomimetic films based on the humidity‐triggered relaxation of polyelectrolyte complex nanoparticles.
[Advanced Healthcare Materials] |
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| Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports] |
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| Investigators showed that communications between the catalytic and hemopexin domains of matrix metalloprotease-1 on type-1 collagen fibrils correlated with its activity.
[Biophysical Journal] |
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| Researchers modeled a three-dimensional cell pair on a patterned substrate, a simple laboratory setup to study intercellular interactions. They explicitly modeled focal adhesions and adherens junctions. These mechanosensing adhesions matured, becoming stabilized by force.
[Biophysical Journal] |
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| Scientists demonstrated that grafts based on porous collagen-based scaffolds, similar to biomaterials utilized clinically in induced regeneration, could deliver and protect embryonic neural stem cells at spinal cord injury (SCI) sites, leading to significant improvement in locomotion recovery in an experimental mouse SCI model.
[NPJ Regenerative Medicine] |
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| Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research] |
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| Lassen Therapeutics announced it has emerged from stealth and secured $31 million in Series A financing to develop antibodies as potential treatments for fibrosis, rare diseases and oncology.
[Lassen Therapeutics] |
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| Bellicum Pharmaceuticals, Inc. announced clearance by the FDA of its investigational new drug application for BPX-603. BPX-603 is a GoCAR-T® product candidate targeting solid tumors that express human epidermal growth factor receptor 2 (HER2).
[Bellicum Pharmaceuticals, Inc.] |
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| China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News] |
| | | 2020-10-02 – 2020-10-05
Boston, Massachusetts, United States |
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| | | | | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | | The University of Washington – Seattle, Washington, United States |
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| | | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| | | Genetech, Inc. – San Francisco, California, United States |
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| | | | Emory University – Atlanta, Georgia, United States |
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| | | The Chinese University of Hong Kong – Hong Kong, China |
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| | | GlaxoSmithKline – Stevenage, United Kingdom |
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| | | Eindhoven University of Technology – Eindhoven, Netherlands |
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| | | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | | Systimmune, Inc. – Redmond, Washington, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
