 | | Vol. 11.26 – 9 July, 2020 |
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| The authors showed for the first time a fully stretchable active-matrix-driven organic light-emitting electrochemical cell array.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers suggested a previously unidentified method for xenogenizing tumors by using fusogenic exosomes to introduce fusogenic viral antigens onto the tumor cell surface.
[Science Advances] |
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| Dogs with Barrett’s esophagus were treated orally with esophageal mucosa ECM (eECM) hydrogel and omeprazole or omeprazole alone for 30 days. eECM treatment resolved esophagitis, reverted metaplasia to a normal, squamous epithelium in four of six animals.
[Science Advances] |
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| The authors designed a novel angiogenic microparticle (C12-MP) comprising Alaska pollock-derived gelatin (ApGltn) modified with a dodecyl group (C12-ApGltn) to stimulate endogenous vascular endothelial growth factor secretion.
[NPG Asia Materials] |
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| Bone morphogenetic protein 1 (BMP-1) overexpression induced marked phenotypic changes in two human cell lines. Scientists investigated how BMP-1 simultaneously affected cell-matrix interactions and growth factor activity in these cells.
[Science Signaling] |
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| IQGAP1 expression was detected by immunohistochemistry, real-time PCR and immunoblot analysis. Lentiviral-mediated stable upregulation or knockdown of IGAQP1, immunoprecipitation, etc. were used in function and mechanism study.
[British Journal of Cancer] |
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| Cancer-associated fibroblasts enhanced the distance and surface area of the invasive cancer mass whilst inhibiting vascular-like network formation. These processes correlated with the upregulation of hepatocyte growth factor, metallopeptidase inhibitor 1 and fibulin-5.
[British Journal of Cancer] |
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| Plasmids expressing scaffolding protein, EPS8 Src-mediated phosphorylation site mutants were expressed in cells containing a normal endogenous level of EPS8. In addition, cells were treated with dasatinib to inhibit Src activity.
[British Journal of Cancer] |
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| To test the possible role Fibulin-1 isoforms could have in regulating Epidermal Growth Factor Receptor signaling and function in lung cancer, scientists performed siRNA mediated knockdown of FBLN1C and FBLN1D in non-small cell lung cancer Calu-1 cells.
[Frontiers in Cell and Developmental Biology] |
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| Versican reduction improved the ex vivo strength and endurance of diaphragm muscle strips. These changes in diaphragm contractile properties in mdx-hdf mice were associated with decreased monocyte and macrophage infiltration and a reduction in the proportion of fibres expressing the slow type I myosin heavy chain isoform
[Scientific Reports] |
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| Scientists established a protocol for the efficient isolation and cultivation of pure populations of human limbal melanocytes, which could be expanded at high yield by using recombinant laminin-511-E8 as culture substrate.
[Scientific Reports] |
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| The authors performed a systematic analysis of the extracellular proteostasis network in Caenorhabditis elegans with an RNA interference screen that targets genes that encode the secreted proteome.
[Nature] |
| | Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer.
[Nature Reviews Cancer] |
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| ProLynx announced it was awarded a Small Business Innovation Research (SBIR) grant from the NIH. The grant was conferred for the development of a long acting parathyroid hormone – PTH(1-34) – that can be administered once-weekly for treatment of hypo-parathyroidism. To achieve this, ProLynx will employ its platform half-life extension technology using its hydrogel microsphere carriers.
[ProLynx] |
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| A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science] |
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| October 20 – October 21
Virtual |
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| | Ludwig Boltzmann Gesellschaft GmbH – Vienna, Austria |
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| | Max Planck Institute for Medical Research – Heidelberg, Germany |
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| | Helmholtz Zentrum München – Neuherberg, Germany |
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| | Drexel University – Philadelphia, Pennsylvania, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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