Extracellular Matrix News Volume 11.27 | Jul 16 2020

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    Extracellular Matrix Cell News Volume 11.27 | July 16 2020


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 11.27 – 16 July, 2020
    TOP STORY

    Synucleinopathy Alters Nanoscale Organization and Diffusion in the Brain Extracellular Space through Hyaluronan Remodeling

    Investigators demonstrated the interplay of extracellular space (ECS), ECM and glia in pathology, unraveling ECS features relevant for the α-synuclein propagation hypothesis and suggesting matrix manipulation as a disease-modifying strategy.
    [Nature Communications]

    Full Article

    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    In Vivo Microscopy Reveals Macrophage Polarization Locally Promotes Coherent Microtubule Dynamics in Migrating Cancer Cells

    Scientists developed an imaging pipeline using plus-end tip tracking and intravital microscopy to quantify microtubules dynamics in live xenograft tumor models.
    [Nature Communications]

    Full Article

    Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis

    The authors showed that integrins play a key role during fly hematopoiesis in regulating cell signals that control the behavior of hematopoietic progenitors. Integrins can regulate hematopoiesis directly, via focal adhesion kinase signaling, and indirectly, by directing ECM assembly and/or maintenance.
    [Current Biology]

    Full Article

    Targeting the MAPK7/MMP9 Axis for Metastasis in Primary Bone Cancer

    Researchers revealed mitogen-activated protein kinase 7/matrix metallopeptidase 9 (MAPK7/MMP9) signaling as a driver for primary bone cancer metastasis. RNA interference knockdown of MAPK7 reduced proliferation, colony formation, migration, tumor growth, macrophage residency/polarisation and lung metastasis.
    [Oncogene]

    Full Article

    TGF-β Regulates Sca-1 Expression and Plasticity of Pre-Neoplastic Mammary Epithelial Stem Cells

    Scientists provided evidence that TGF-β disrupted the lineage commitment and promoted the accumulation of tumor-initiating cells in pre-neoplastic cells.
    [Scientific Reports]

    Full Article

    Secretion of a Mammalian Chondroitinase ABC Aids Glial Integration at PNS/CNS Boundaries

    Researchers used a lentiviral chondroitinase ABC, capable of being secreted from mammalian cells, to examine the repercussions of chondroitin sulphate proteoglycans digestion upon Schwann cell behaviour in vitro.
    [Scientific Reports]

    Full Article

    Potential of MMP-9 Based Nanoparticles at Optimizing the Cow Dry Period: Pulling Apart the Effects of MMP-9 and Nanoparticles

    Scientists provided relevant information on the future use of protein inclusion bodies in cow mammary gland and the role of matrix metalloproteinase-9 at dry-off.
    [Scientific Reports]

    Full Article

    A Multi-Layered Scaffold for Regeneration of Smooth Muscle and Connective Tissue Layers

    Researchers showed that within a single scaffold, the architecture supported alignment of contractile smooth muscle cells and deposition by fibroblasts of a meshwork of extracellular matrix fibrils.
    [Journal of Biomedical Materials Research Part A]

    Abstract

    Explore tools and resources for your return to the lab
    REVIEWS

    A New Dawn for Eosinophils in the Tumor Microenvironment

    Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.
    [Nature Reviews Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    An Analysis of Ways to Decarbonize Conference Travel after COVID-19

    The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
    [Nature News]

    Editorial

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    JOB OPPORTUNITIES

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    TU Dresden – Dresden, Germany

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    Helmholtz Zentrum München – Neuherberg, Germany

    Postdoctoral Fellow Position – Primitive Collagen and Stem Cell Chondrogenesis

    Drexel University – Philadelphia, Pennsylvania, United States

    Postdoctoral Associate – Optic Nerve Head Extracellular Matrix Remodeling

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

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