 | | Vol. 12.06 – 18 February, 2021 |
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| The authors developed a microrheology-based force spectrum analysis technique to dissect the active and passive fluctuations of the ECM in three-dimensional cell culture models.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists revealed previously unidentified insights into the modulation of macrophages to regulate tumor-associated fibrosis, providing a feasible strategy to reverse the immunosuppressive environment and improve the therapeutic outcome of checkpoint immunotherapies.
[Science Advances] |
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| Researchers identified 3,523 proteins including 185 ECM proteins and quantified 117 of them. They detected previously unknown proteome and matrisome features during pancreas development and maturation.
[Nature Communications] |
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| The authors demonstrated that under nutrient-replete conditions, loss of autophagy in pancreatic ductal adenocarcinoma led to a relatively restricted impairment of amino acid pools, with cysteine levels showing a significant drop.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators found that the imbalance of TGF-β1/BMP-7 pathways was associated with aggressive pathological features and poor clinical outcomes in hepatocellular carcinoma.
[Molecular Therapy] |
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| Researchers investigated the interaction between cystatin C (Cst-3) and heparan sulfate (HS), a major component of ECM. They discovered that Cst-3 is a HS-binding protein only at acidic pH.
[Communications Biology] |
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| Investigators showed that osteoblasts and bone marrow–derived mesenchymal stem cell pools expressed TRPM8, a Ca2+-ion channel critical for bone-mineralization. TRPM8 inhibition triggered up-regulation of key osteogenesis factors; and increased mineralization by osteoblasts.
[Scientific Reports] |
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| Scientists suggested that tumor stiffness could be at the crossroad of three major processes, i.e. matrix remodeling, MEK activation and stromal metabolic switch that might explain at least in part mesenchymal high-grade serous ovarian cancers aggressiveness.
[Scientific Reports] |
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| Using neonatal mouse hearts and ventricle explants of various stiffness, researchers investigated the synergistic effects of microenvironment stiffness and exogenous fetal ECM on cardiac post-injury response, cardiomyocyte proliferation, cytoskeleton organization, and YAP activity.
[Biophysical Journal] |
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| The authors present a novel biomimetic substrate with submicron topographies that is capable of mimicking the mechanical and structural cues of the ECM while benefiting from high-precision, easy-to-reproduce, and scalable photolithography-based fabrication techniques.
[Biophysical Journal] |
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| Scientists developed a 3D computational model that simulates cell migration and proliferation on a scaffold. The model generated an adjustable 3D porous scaffold environment with a defined pore size and Young modulus.
[Biophysical Journal] |
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| The author touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the matrix and influences that the matrix has on tumour onset, progression and metastatic dissemination, before summarizing the ongoing work in the field aimed at developing therapies to co-target the matrix in cancer and cancer metastasis.
[Nature Reviews Cancer] |
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| Avacta Group plc announced that it has received approval from the Medicines and Healthcare Products Regulatory Agency for its CTA in the UK for a Phase I study of its lead pre|CISIONTM pro-drug, AVA6000 pro-doxorubicin.
[Avacta Group plc] |
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| June 21 – 26, 2021
Virtual |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Merck Sharp and Dohme Limited – London, England, United Kingdom |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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