 | | Vol. 12.09 – 11 March, 2021 |
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| Researchers addressed the therapeutic potential of histone deacetylases (HDAC) inhibition in a model of established diastolic dysfunction with preserved ejection fraction.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators uncovered the mechanism underlying cancer associated fibroblasts (CAFs)-mediated tumor immune evasion and develop novel therapeutic strategies targeting CAFs for enhancing immune checkpoint inhibitor efficacy in oesophageal squamous cell carcinoma and colorectal cancer.
[Gut] |
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| Scientists investigated the novel cellular crosstalk among carcinoma-associated fibroblasts, tumor cells, and tumor‐associated neutrophils during different stages of hepatocellular carcinoma pathogenesis.
[Hepatology] |
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| The authors describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels.
[Developmental Cell] |
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| Researchers showed that phosphorylation and activation of HER3 in luminal breast cancer cells occurred in a paracrine manner and was mediated by NRG1 expressed by cancer-associated fibroblasts.
[Oncogene] |
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| Investigators developed a bioprinting strategy to engineer prevascularised tissues in vitro and to investigate the capacity of such constructs to enhance the vascularisation and regeneration of large bone defects in vivo.
[Acta Biomaterialia] |
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| To understand the laminar interaction dynamics after ECM digestion, scientists used time-domain conditional Granger causality measures to identify the increased drive of supragranular layers towards deeper infragranular layers.
[Communications Biology] |
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| The impact of a type I collagen matrix orientation and fibrous architecture on cell proliferation and response to estrogen receptor therapy were examined using estrogen-dependent breast tumor cells cultured in a hormone-restricted environment.
[ACS Biomaterials Science & Engineering] |
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| Mesenchymal stem cells (MSCs) as single cells, assembled into microtissues or their corresponding secretomes were combined with a collagen scaffold and incubated on the chicken embryo chorioallantoic membrane for seven days.
[Scientific Reports] |
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| Scientists focus on fate-determining roles of the inflammasomes and the principal downstream effector cytokine, IL-1β, in the tumor microenvironment.
[npj Precision Oncology] |
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| Investigators discuss the spatiotemporal changes in ECM composition during cardiac development that support distinct aspects of heart morphogenesis. They highlight conserved requirements for specific ECM components in human cardiac development, and discuss emerging evidence of a central role for the ECM in promoting heart regeneration.
[Development] |
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| Scientists around the world are scrambling to secure basic supplies in the wake of the COVID‑19 pandemic, which has increased demand for testing materials while disrupting manufacturing and distribution channels.
[Nature News] |
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| The Schulich School of Engineering (SSE), under Dr. Michael Kallos, PhD, a professor in the Department of Chemical and Petroleum Engineering, and director of the Biomedical Engineering Calgary Initiative, has been developing technologies to safely and reproducibly grow stem cells- whether they be skin cells, neural cells, or cells in any other part of the body.
[University of Calgary] |
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| | Tulane School of Medicine – New Orleans, Louisiana, United States |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
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Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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