| Vol. 12.13 – 8 April, 2021 |
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| Scientists found that KRAS‐mutant tumors displayed lower expression of genes related to the tumor stroma and remodeling of the ECM. [Molecular Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression. [Experimental and Molecular Medicine] |
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| Researchers report a novel method to fabricate polymer/carbon nanotube (CNT) composite yarns by electrospinning polycaprolactone/gelatin into a bath of CNT dispersion and extracting electrospun fibers out of the bath. In vitro biological test results showed that within a limited range of CNT concentrations in the bath, the yarns exhibited good biocompatibility and the ability to guide cell elongation and alignment. [ACS Biomaterials Science & Engineering] |
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| The expression of ECM-related genes was explored for prognostic and immunological implication in clear cell renal clear cell carcinoma. [Scientific Reports] |
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| Scientists demonstrated that a reduced opticin levels in ROP vitreous were regulated by matrix metalloproteinases (MMPs) secreted by activated microglia. [Scientific Reports] |
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| Researchers compared the efficacy of pressure driven perfusion with electrokinetic perfusion toward reducing cell mortality in 3D cultures of Matrigel extracellular matrix. [Tissue Engineering Part A] |
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| The authors studied the functional role of complement factor I (CFI) in the progression of cutaneous squamous cell carcinoma (cSCC). CFI was knocked down in cSCC cells and RNA‐seq analysis was performed. [Experimental Dermatology] |
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| Researchers explored the underlying mechanisms of how pancreatic ductal adenocarcinoma-derived exosomes modulate the liver microenvironment and promote metastasis. [Pancreas] |
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| Scientists designed a 3D printed bead generator that uses an airflow to cleave beads from a stream of hydrogel solution. They demonstrated that viability and biological function of chondrocytes were not adversely affected by high frequency using this bead generator. [Biomedical Microdevices] |
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| This review examines the current knowledge of heparan sulfate proteoglycans in the stem cell niche, human stem cell models, and their role in the development of 3D models that mimic the in vivo neural ECM. [Seminars in Thrombosis and Hemostasis] |
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| Ionis Pharmaceuticals, Inc. announced the initiation of a Phase III clinical trial of ION363 in patients with amyotrophic lateral sclerosis (ALS) with mutations in the fused in sarcoma gene. [Ionis Pharmaceuticals, Inc.] |
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| May 26 – 28, 2021 Virtual |
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| Francis Crick Institute – London, England, United Kingdom |
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| STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| Maastricht University – Maastricht, Netherlands |
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| Florida Atlantic University – Jupiter, Florida, United States |
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| Tulane School of Medicine – New Orleans, Louisiana, United States |
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