Extracellular Matrix News Volume 12.14 | Apr 15 2021

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    2021-15-04 | ECM 12.14


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.14 – 15 April, 2021
    TOP STORY

    Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

    Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.
    [Circulation Research]

    Abstract

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    EFA6B Regulates a Stop Signal for Collective Invasion in Breast Cancer

    Investigators report that loss of exchange factor for ARF6, B (EFA6B) triggered a transcriptional reprogramming of cell-to-ECM interaction machinery and unleashed CDC42-dependent collective invasion in collagen.
    [Nature Communications]

    Full Article

    Measuring the Elastic Modulus of Soft Culture Surfaces and Three-Dimensional Hydrogels Using Atomic Force Microscopy

    Researchers describe a protocol for measuring Young’s modulus of soft 2D surfaces and 3D hydrogels using atomic force microscopy (AFM) force spectroscopy. They provide instructions for preparing hydrogels with and without encapsulated live cells, and provide a method for mounting samples within the AFM.
    [Nature Protocols]

    Abstract

    Exercise Training Improves Tumor Control by Increasing CD8+ T-Cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade

    Scientists implanted breast cancer cells orthotopically in wild-type or Cxcr3-/- female mice and initiated intensity-controlled exercise training sessions when tumors reached ~100 mm3. They characterized the tumor microenvironment using flow cytometry, transcriptome analysis, proteome array, ELISA, and immunohistochemistry.
    [Cancer Immunology Research]

    AbstractPress Release

    Silk Fibroin Enhances Cytocompatibilty and Dimensional Stability of Alginate Hydrogels for Light-Based Three-Dimensional Bioprinting

    Alginate derivatives were synthesized to induce rapid gelation, and a bioink was prepared by mixing these alginate derivatives with silk fibroin to enhance cell compatibility.
    [Biomacromolecules]

    AbstractGraphical Abstract

    A Liquid Culture Cancer Spheroid Model Reveals Low PI3K/Akt Pathway Activity and Low Adhesiveness to the Extracellular Matrix

    Scientists examined liquid culture cancer spheroids for the acquisition of apical‐basal polarity, sensitivity to an Akt inhibitor and interaction with ECM.
    [FEBS Journal]

    Abstract

    Silk Films with Nanotopography and Extracellular Proteins Enhance Corneal Epithelial Wound Healing

    Silk films with either flat or nanotopography patterned parallel ridge widths of 2000, 1000, 800 nm surfaces were combined with ECM which included collagen type I, fibronectin, laminin, and Poly-D-Lysine to accelerate corneal wound healing.
    [Scientific Reports]

    Full Article

    Sex and Tamoxifen Confound Murine Experimental Studies in Cardiovascular Tissue Engineering

    The authors describe the importance of challenging the baseline assumption that tamoxifen is inert when used as a small molecule inducer in the context of cardiovascular tissue engineering.
    [Scientific Reports]

    Full Article

    Extracellular Matrix Scaffolds Derived from Different Musculoskeletal Tissues Drive Distinct Macrophage Phenotypes and Direct Tissue-Specific Cellular Differentiation

    Researchers demonstrated that macrophages adopt distinct phenotypes when exposed to articular cartilage, ligament and growth plate derived ECM scaffolds.
    [Journal of Immunology and Regenerative Medicine]

    Full ArticleGraphical Abstract

    View tips on how to plan ahead and get the most out of your time in the lab.
    REVIEWS

    Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

    Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity.
    [Clinical Cancer Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    NeoProgen, Inc. Receives First Granted Patent for Method to Treat Cardiac Conditions Using Neonatal Heart-Derived Medicinal Signaling Cells (nMSCs) and/or Their Secretomes/Exosomes from the US Patent Office

    NeoProgen, Inc. announced that it has received a patent from the United States Patent Office Patent No.: US 10.967,007 B2 “Cardiac Stem Cells for Cardiac Repair”.
    [NeoProgen, Inc. (Business Wire, Inc.)]

    Press Release

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    JOB OPPORTUNITIES

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    King’s College London – London, England, United Kingdom

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    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

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    Francis Crick Institute – London, England, United Kingdom

    Assistant Professor – Neuroregeneration, Advanced Cellular Technology, and Imaging for Regenerative Medicine

    Maastricht University – Maastricht, Netherlands

    Postdoctoral Fellow – Neural Basis of Memory

    Florida Atlantic University – Jupiter, Florida, United States

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