Extracellular Matrix News Volume 12.15 | Apr 22 2021

    By
    Justin.choi
    -
    0
    21







    2021-22-04 | ECM 12.15


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.15 – 22 April, 2021
    TOP STORY

    Nuclear Mechanosensing Drives Chromatin Remodeling in Persistently Activated Fibroblasts

    Using fibroblasts from porcine aortic valves cultured on hydrogels that could be softened via exposure to ultraviolet light, scientists showed that increased extracellular stiffness activated the fibroblasts, and that cumulative tension on the nuclear membrane and increases in the activity of histone deacetylases transformed transiently activated fibroblasts into myofibroblasts displaying condensed chromatin with genome-wide alterations.
    [Nature Biomedical Engineering]

    Abstract

    The Immunology Podcast is here. Find it wherever you get your podcasts.
    PUBLICATIONSRanked by the impact factor of the journal

    Tenascin-C-Mediated Suppression of Extracellular Matrix Adhesion Force Promotes Entheseal New Bone Formation through Activation of Hippo Signaling in Ankylosing Spondylitis

    The authors identified the role of tenascin-C in entheseal new bone formation and explored the underlying molecular mechanism.
    [Annals of the Rheumatic Diseases]

    Abstract

    Ultrathin Micromolded 3D Scaffolds for High-Density Photoreceptor Layer Reconstruction

    Researchers describe the microfabrication of a biodegradable scaffold patterned for high-density photoreceptor replacement. The “ice cube tray” structure optimized mechanical properties and cell-to-biomaterial load, enabling production of a multicellular photoreceptor layer designed for outer retinal reconstruction.
    [Science Advances]

    Full Article

    Force-FAK Signaling Coupling at Individual Focal Adhesions Coordinates Mechanosensing and Microtissue Repair

    Using cells adhering to deformable micropillar arrays, the authors demonstrated that traction force and FAK localization as well as traction force and Y397-FAK phosphorylation were linearly coupled at individual focal adhesions on stiff, but not soft, substrates.
    [Nature Communications]

    Full Article

    Suppression of Pancreatic Ductal Adenocarcinoma Growth and Metastasis by Fibrillar Collagens Produced Selectively by Tumor Cells

    Scientists showed that the enzyme responsible for procollagen C-proteinase activity, bone morphogenetic protein1, selectively suppressed tumor growth and metastasis in cells expressing high levels of COL1A1.
    [Nature Communications]

    Full Article

    Fibrotic Extracellular Matrix Induces Release of Extracellular Vesicles with Pro-Fibrotic miRNA from Fibrocytes

    The extracellular vesicles of fibrocytes derived from fibrotic lungs significantly upregulated the expression of col1a1 of fibroblasts. Culturing on rigid plates or fibrotic decellularized lung scaffolds increased miR-21-5 p expression compared with soft plates or normal lung scaffolds.
    [Thorax]

    Abstract

    Matrix Stiffness Changes Affect Astrocyte Phenotype in an In Vitro Injury Model

    Investigators established an in vitro model to assess the responses of astrocytes to matrix stiffness changes that may be related to pathophysiology.
    [NPG Asia Materials]

    Full Article

    Mechanosensitive Smooth Muscle Cell Phenotypic Plasticity Emerging from a Null State and the Balance between Rac and Rho

    Researchers showed that vascular smooth muscle cell plasticity is mechanosensitive and that both the de-differentiated and differentiated fates are promoted by the same ECM stiffness.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Multiplexed Targeting of miRNA-210 in Stem Cell-Derived Extracellular Vesicles Promotes Selective Regeneration in Ischemic Hearts

    Under hypoxic conditions, the authors observed that ASCmiR-210 inhibited apoptosis by modulating protein tyrosine phosphatase 1B and death-associated protein kinase 1.
    [Experimental and Molecular Medicine]

    Full Article

    αvβ3 Integrin Induces Partial EMT Independent of TGF-β Signaling

    Investigators demonstrated that αvβ3 integrin induced partial epithelial–mesenchymal transition, which was characterized by acquiring mesenchymal phenotypes while retaining epithelial markers.
    [Communications Biology]

    Full Article

    3D Cell Sheet Structure Augments Mesenchymal Stem Cell Cytokine Production

    MSCs cultivated on temperature-responsive culture dishes to a confluent 2D monolayer were harvested by temperature reduction from 37 to 20°C that induced a surface wettability transition from hydrophobic to hydrophilic.
    [Scientific Reports]

    Full Article

    Join us in our mission to advance the pursuit of scientific knowledge by supplying high-quality, innovative reagents, tools and services that enable life science research.
    REVIEWS

    Novel Approaches to Target the Microenvironment of Bone Metastasis

    The authors describe the functional roles of the bone microenvironment and its components in the initiation and propagation of skeletal metastases, outline the biology and clinical relevance of circulating tumor cells and disseminated tumor cells, and discuss established and future therapeutic approaches that specifically target defined components of the bone microenvironment to prevent or treat skeletal metastases.
    [Nature Reviews Clinical Oncology]

    Abstract

    Reciprocal Regulation of Cellular Mechanics and Metabolism

    Researchers examine the links between metabolism and mechanics, highlighting signaling pathways involved in the regulation and response to cellular mechanosensing.
    [Nature Metabolism]

    Abstract

    INDUSTRY AND POLICY NEWS

    Organicell Announces FDA Approval of IND Application for the Use of Zofin™ in the Treatment of Osteoarthritis

    Organicell Regenerative Medicine, Inc. announced that the FDA has approved the Investigational New Drug application for its lead product, Zofin™, in the treatment of knee osteoarthritis.
    [Organicell Regenerative Medicine, Inc. (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral/Research Fellow Position – 3D-Printing & Scaffold Design for Drug/Gene Delivery in Tissue Engineering

    Nanyang Technological University – Singapore, Singapore

    Postdoctoral/Research Fellow Position – In Vivo Scaffold Implantation Studies for Tissue Engineering Research

    Nanyang Technological University – Singapore, Singapore

    Scientist/Engineer – Matrix Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Research Associate – Cell and Tissue Mechanobiology

    King’s College London – London, England, United Kingdom

    Senior/Laboratory Research Scientist – Cell and Tissue Mechanobiology

    Francis Crick Institute – London, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Extracellular Matrix News Twitter