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| Through structure-activity relationship studies focused on the actin-binding tail region of MycB, scientists identified a potent truncated derivative that inhibits polymerization of G-actin and severs F-actin by binding to actin’s barbed end cleft.
[Journal of the American Chemical Society] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors highlighted the unprecedented therapeutic potential of an implantable vascularized hydrogel with ovarian spheroids against menopause and suggested that it might be used as an alternative approach to standard hormone therapy.
[Science Advances] |
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| Scientists combined cyclic arginine-glycine-aspartatic-ligand-decorated DNA tension sensors with DNA-PAINT super-resolution microscopy to study the mechanical engagement of single integrin receptors and the downstream influence on actin bundling.
[Nature Communications] |
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| A hybrid hydrogel dressing was developed for localized and sustained delivery of matrix metalloproteinase 9 small interfering RNA (MMP-9 siRNA).
[Journal of Nanobiotechnology] |
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| In vitro, TGF-β1 treatment augmented glycogen synthase kinase 3β expression in tubular epithelial cells, concomitant with dedifferentiation, cell cycle arrest at G2/M phase, excessive accumulation of extracellular matrix, and overproduction of profibrotic cytokines like PAI-1 and CTGF.
[Cell Death & Disease] |
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| Researchers indicated that ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS-5) was downregulated in human intracranial aneurysm (IA), and compensatory ADAMTS-5 administration inhibited IA development and rupture with potentially important implications for treating this cerebrovascular disease.
[Aging] |
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| Scientists analyzed the celastrol mediated inhibition of proliferation, invasion and migration of human cervical HeLa cancer cells through down‐regulation of matrix metalloproteinase‐2 (MMP‐2) and MMP‐9.
[Journal of Cellular and Molecular Medicine] |
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| Researchers found that miR-206 could promote ECM accumulation through targeted inhibition of DNA Methyltransferase 3A (DNMT3A), inhibiting the malignant development of hemangioma endothelial cells and relieving infantile hemangioma.
[Cell Cycle] |
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| Investigators selected a subset of enriched microRNAs and transfected synthetic mimics back into resting zone and growth zone cells. Transfecting growth plate chondrocytes with select microRNA produced a broad range of phenotypic responses indicating that matrix vesicle-based microRNAs were involved in the regulation of these cells.
[Calcified Tissue International] |
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| The authors summarize the emerging understanding of the complex roles of platelet-derived microvesicles in the development and progression of cancer and cancer co-morbidities.
[Blood] |
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| Chiesi Global Rare Diseases announced that the U.S FDA has approved FERRIPROX® for the treatment of transfusional iron overload due to sickle cell disease or other anemias in adult and pediatric patients 3 years of age and older.
[Chiesi Global Rare Diseases] |
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| June 21 – 26, 2021
Virtual |
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| | Nanyang Technological University – Singapore, Singapore |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Stanford University – Stanford, California, United States |
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| | Nanyang Technological University – Singapore, Singapore |
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| UCLA – Los Angeles, California, United States |
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