 | | Vol. 12.18 – 13 May, 2021 |
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| The authors constructed fibroblast atlases by integrating single-cell transcriptomic data from about 230,000 fibroblasts across 17 tissues, 50 datasets, 11 disease states, and 2 species.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Through structure-activity relationship studies focused on the actin-binding tail region of MycB, scientists identified a potent truncated derivative that inhibited polymerization of G-actin and severed F-actin by binding to actin’s barbed end cleft.
[Journal of the American Chemical Society] |
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| The authors postulated the hypothesis that DDR1 and its ligand might ignite the interaction between uveal melanoma cells and their surrounding niche of the liver thereby conferring strengthened survival, proliferation, stemness and eventually promoting metastatic colonization in the liver.
[Signal Transduction and Targeted Therapy] |
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| The epithelial–fibroblast interface, namely, hair germ–dermal papilla interface, made asymmetrically organized site-specific heterogeneity in the basement membrane (BM), defined by the newly characterized interface, hook and mesh BMs.
[Nature Communications] |
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| Scientists demonstrated that tissue mechanics, or the stiffness of the wound bed, the ECM, and the stiffness of the cells also partook during wound-induced hair neogenesis; the hair primordia formation was not exclusive to molecular signaling events.
[Nature Communications] |
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| Investigators used a combination of in vivo postpartum breast cancer models and in vitro assays to study the effects of inactivation of the MNK1/2-eIF4E axis on the pro-tumor function of select cells of the TME
[Cancer Research] |
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| The authors analyzed seven million autosomal germline variants in the TCGA cohort and test for association with established immune-related phenotypes that describe the tumor immune microenvironment.
[Cell Reports] |
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| Since inflammation is known to facilitate HIV sexual transmission, researchers investigated the role of hyaluronic acid in the genital mucosal fibroblast-mediated enhancement of HIV infection.
[Mucosal Immunology] |
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| A hybrid hydrogel dressing was developed for localized and sustained delivery of matrix metalloproteinase 9 small interfering RNA (MMP-9 siRNA).
[Journal of Nanobiotechnology] |
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| Researchers indicated that ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS-5) was downregulated in the human intracranial aneurysm (IA), and compensatory ADAMTS-5 administration inhibited IA development and rupture with potentially important implications for treating this cerebrovascular disease.
[Aging] |
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| Scientists analyzed the celastrol-mediated inhibition of proliferation, invasion, and migration of human cervical HeLa cancer cells through down‐regulation of matrix metalloproteinase‐2 (MMP‐2) and MMP‐9.
[Journal of Cellular and Molecular Medicine] |
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| The authors summarize the emerging understanding of the complex roles of platelet-derived microvesicles in the development and progression of cancer and cancer co-morbidities.
[Blood] |
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| Scientists discuss extracellular vesicle (EV) biology in 3D culture correlates of the tumor microenvironment (TME). This includes EV communication between cell types of the TME, differences in EV biogenesis and signaling associated with differing scaffold choices and in scaffold-free 3D cultures, and cultivation of the premetastatic niche.
[International Journal of Molecular Sciences] |
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| Chiesi Global Rare Diseases announced that the FDA has approved FERRIPROX® for the treatment of transfusional iron overload due to sickle cell disease or other anemias in adult and pediatric patients three years of age and older.
[CHIESI USA, Inc.] |
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| CSA Medical, Inc. announced that all subjects have been enrolled in the RejuvenAir® System study. The aim of this study is to determine the mechanism by which Metered CryoSpray reduces the density of goblet cells responsible for over-producing mucus and observe the re-growth of healthy cilia in the airways.
[CSA Medical, Inc. (Cision US, Inc.)] |
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| May 25 – 27, 2021
Virtual |
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| | University of Nebraska Medical Center – Omaha, Nebraska. United States |
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| | Bristol Myers Squibb – Redwood City, California, United States |
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| | Stanford University – Stanford, California, United States |
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| | Zhejiang University – Zhejiang, China |
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| | Nanyang Technological University – Singapore, Singapore |
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