Extracellular Matrix News Volume 12.23 | Jun 17 2021

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    2021-06-17 | ECM 12.23


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.23 – 17 June, 2021
    TOP STORY

    Budding Epithelial Morphogenesis Driven by Cell-Matrix versus Cell-Cell Adhesion

    Researchers performed live-organ imaging of mouse embryonic salivary glands at single-cell resolution to reveal that budding morphogenesis was driven by expansion and folding of a distinct epithelial surface cell sheet characterized by strong cell-matrix adhesions and weak cell-cell adhesions.
    [Cell]

    Abstract

    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Engineered Bridge Protein with Dual Affinity for Bone Morphogenetic Protein-2 and Collagen Enhances Bone Regeneration for Spinal Fusion

    Scientists developed a translational protein engineering-based approach to reduce the dose and thereby improved the safety of rhBMP-2 delivered in a collagen sponge, as in InFUSE Bone Graft.
    [Science Advances]

    Full Article

    Macrophage Depletion Induces Edema through Release of Matrix-Degrading Proteases and Proteoglycan Deposition

    Extended antibody treatment of mice caused marked body weight gain, an indicator of enhanced body fluid retention. This was associated with an increase of ECM–remodeling metalloproteinases (MMPs), namely MMP2 and MMP3, and enhanced deposition of hyaluronan and proteoglycans, leading to skin thickening.
    [Science Translational Medicine]

    Abstract

    Vapor-Phased Fabrication and Modulation of Cell-Laden Scaffolding Materials

    Investigators reported a vapor-phased fabrication process for constructing 3D modulated scaffold materials via simple steps based on controlling mass transport of vapor sublimation and deposition.
    [Nature Communications]

    Full Article

    Synthetic Extracellular Matrices with Tailored Adhesiveness and Degradability Support Lumen Formation during Angiogenic Sprouting

    The authors showed that long, perfusable tubes only developed if hydrogel adhesiveness and degradability were fine-tuned to support the initial collective invasion of endothelial cells and, at the same time, allowed for matrix remodeling to permit the opening of lumens.
    [Nature Communications]

    Full Article

    COL11A1 Activates Cancer-Associated Fibroblasts by Modulating TGF-β3 through the NF-κB/IGFBP2 Axis in Ovarian Cancer Cells

    Collagen type XI alpha 1 (COL11A1) is overexpressed in cancer-associated fibroblasts (CAFs); therefore this study examined its role during CAF activation in epithelial ovarian cancer.
    [Oncogene]

    Abstract

    Pseudogene ACTBP2 Increases Blood-Brain Barrier Permeability by Promoting KHDRBS2 Transcription through Recruitment of KMT2D/WDR5 in Aβ1–42 Microenvironment

    Investigators elucidated the function and possible molecular mechanisms of the effect of pseudogene ACTBP2 on the permeability of the blood-brain barrier in the Aβ1–42 microenvironment.
    [Cell Death Discovery]

    Full Article

    A Combined Biomarker Approach for Characterizing Extracellular Matrix Profiles in Acute Myocardial Infarction

    The authors conducted exploratory factor analysis to examine the interrelationships between ECM biomarkers, and cluster analysis to identify if distinct ECM profiles could distinguish patient risk in acute myocardial infarction.
    [Scientific Reports]

    Full Article

    Advanced Mycelium Materials as Potential Self-Growing Biomedical Scaffolds

    Investigators demonstrated the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.
    [Scientific Reports]

    Full Article

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    ATP and Cancer Immunosurveillance

    The authors discuss the molecular and cellular mechanisms through which ATP and its degradation products influence cancer immunosurveillance, with a focus on therapeutically targetable circuitries.
    [EMBO Journal]

    Abstract

    Tumor Microenvironment and Radioresistance

    Scientists provide an overview of the tumor microenvironment and characteristics of tumor tissues, both of which affect the malignant phenotypes and radioresistance of cancer cells.
    [Experimental and Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    First Patient Enrolled in Restrata® Randomized Controlled Trial

    Acera Surgical, Inc. has announced its first patient enrollment in a clinical study evaluating Restrata®, Acera’s leading wound care product, for the treatment of non-healing diabetic foot ulcers.
    [Acera Surgical, Inc. (PR Newswire, LLC)]

    Press Release

    FEATURED EVENT

    8th International Conference on Stem Cell Engineering 2021

    July 8 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Tissue Development and Regeneration

    University of Southern California – Los Angeles, California, United States

    Postdoctoral Position – Protective Tissue Factors in Autoimmune Diseases

    BioMed X Research Institute – Heidelberg, Germany

    Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

    City of Hope – Monrovia, California, United States

    Research Technologist – Neurological Surgery

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Fellow – Bone Metastatic Prostate Cancer

    H. Lee Moffitt Cancer Center – Tampa, Florida, United States

    > See All Jobs

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