 | | Vol. 12.24 – 24 June, 2021 |
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| Scientists mapped 3D cellular forces in mouse intestinal organoids grown on soft hydrogels and showed that these organoids exhibited a non-monotonic stress distribution that defined mechanical and functional compartments.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed in a reconstituted in vitro system that vimentin intermediate filaments stabilized microtubules against depolymerization and supported microtubule rescue.
[Nature Communications] |
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| Using cell models from systematic ECM screen to collagen-based 2D and 3D cultures, the authors demonstrated that both specific ECM substrates and stiffness increased resistance to platinum-mediated, apoptosis-inducing DNA damage via FAK and β1 integrin-pMLC-YAP signaling.
[Nature Communications] |
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| Scientists investigated the benefit of a combined-tissue engineering strategy by loading homologous bone MSCs and Schwann cells in 3D scaffolds.
[Biofabrication] |
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| Investigators found that the RNA-binding protein Musashi1 (Msi1) deficiency decreased the expression and activity of Mmp9, an important enzyme in ECM degradation.
[Oncogene] |
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| The impact of long noncoding RNA expression on immune-related molecular and cellular components in the tumor immune microenvironment (TIME) at the pan-cancer level was systematically investigated and lncRNA modifier candidates of infiltrating immune cells within the TIME were identified.
[npj Genomic Medicine] |
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| A highly acidified microenvironment of melanoma induced the expression of G-protein-coupled receptor in T cells, which weakened their effective function and promoted tumor growth.
[Cancer Gene Therapy] |
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| Scientists demonstrated that both diabetic foot ulcers and venous leg ulcers exhibited global deregulation of cytoskeletal organization in genomic comparison to normal skin and acute wounds.
[Communications Biology] |
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| Researchers evaluated the reliability and validity of the 5-scale grading system to interpret the point-of-care immunoassay for tear matrix metalloproteinase-9.
[Scientific Reports] |
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| The authors found that cells lacking the desmosomal cadherin Desmoglein-2 displayed a significant increase in spreading area on both fibronectin and collagen, compared to control A431 cells.
[Scientific Reports] |
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| Investigators focus on epithelial tissues, discussing the molecular mechanisms of mitotic spindle orientation in vertebrate cells, and how this machinery is regulated by epithelial cues and extracellular signals to maintain tissue cohesiveness during mitosis.
[Nature Reviews Molecular Cell Biology] |
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| Scientists discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organizing cultures, or by controlled assembly through microfluidic and print-based technologies.
[Communications Biology] |
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| 3D Systems, Inc.and CollPlant Biotechnologies announced they have signed a co-development agreement for a 3D bioprinted regenerative soft tissue matrix for use in breast reconstruction procedures in combination with an implant.
[3D Systems, Inc.] |
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| September 22 – 24, 2021
Virtual |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Eastern Virginia Medical School – Norfolk, Virginia, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | BioMed X Research Institute – Heidelberg, Germany |
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| | City of Hope – Monrovia, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
Extracellular Matrix News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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