| Vol. 12.25 – 8 July, 2021 |
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| Scientists showed that in the mouse visual cortex, astrocytes controlled critical-period closure. They uncovered the underlying pathway, which involved astrocytic regulation of the ECM, allowing interneuron maturation. [Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that lumican, an ECM protein normally associated with collagens, was elevated in sepsis patients’ blood, while lumican-null mice resolved polymicrobial sepsis poorly, with reduced bacterial clearance and greater body weight loss. [Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors demonstrated that interdomain communication through small RNA–containing membrane vesicles was bidirectional and that miRNAs in extracellular vesicles secreted by human airway epithelial cells regulated protein expression, antibiotic sensitivity, and biofilm formation by P. aeruginosa. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the AITL tumor microenvironment. [Leukemia] |
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| Fibrotic-like matrix stiffness promoted distinct metastatic phenotypes in breast cancer cells, which were preserved after transition to softer microenvironments, such as bone marrow. [Cell Reports] |
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| Investigators demonstrated that extracellular collagen matrix formation could be targeted in uveal melanoma by inhibiting hypoxia-induced P4HA1 and P4HA2 expression, warranting further development of this strategy in patients with uveal melanoma. [Oncogene] |
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| The authors synthesized a sodium alginate (SA)/collagen type I (Col)/stromal cell-derived factor-1 (SDF-1) hydrogel and investigated whether the SA/Col/SDF-1 hydrogel loaded with bone marrow-derived mesenchymal stem cells (BMSCs) had therapeutic effects on a traumatic brain injury model. [Acta Biomaterialia] |
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| Researchers highlighted key steps in the aryl polyene biosynthesis pathway that could be explored as potential drug targets for complementary strategies to reduce fitness and prevent biofilm formation of multi-drug resistant pathogens. [npj Biofilms and Microbiomes] |
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| Scientists used Costello syndrome-induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of ECM remodeling proteins contributed to impaired osteogenesis. [Stem Cell Reports] |
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| Using single-cell RNA-sequencing, investigators identified and validated the in situ localization of three smooth muscle subtypes and two novel fibroblast subtypes in human prostate. [Journal of Pathology] |
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| A patient-derived scaffold model was evaluated as a testing platform for the endocrine therapies (Z)-4-Hydroxytamoxifen and fulvestrant as well as the CDK4/6-inhibitor palbociclib, monitoring the treatment responses in breast cancer cell lines MCF7 and T47D adapted to the patient-based microenvironments. [Scientific Reports] |
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| Scientists describe the multidimensional interplays between B cells and other immune cells in the tumor microenvironment, which account for the regulation of B cell differentiation and function in situ. [Oncogene] |
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| RepliCel Life Sciences, Inc. announced it has submitted its application to Japan’s Ministry of Health, Labour, and Welfare for approval to manufacture the company’s RCT-01 cell therapy for chronic tendinopathy and RCS-01 cell therapy for aging and sun-damaged skin for its upcoming clinical studies. [RepliCel Life Sciences, Inc.] |
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| Histogen Inc. has announced the initiation of its Phase I/II clinical trial of HST 003 to evaluate the safety and efficacy of human ECM implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline cartilage in combination with a microfracture procedure. [Histogen Inc.] |
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| August 18 – 19, 2021 Virtual |
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| Francis Crick Institute – London, England, United Kingdom |
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| North Carolina A&T State University – Greensboro, North Carolina, United States |
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| Springer Nature – Multiple Locations |
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| FibroBiologics – Houston, Texas, United States |
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| Research Center for Molecular Medicine – Vienna, Austria |
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