Extracellular Matrix News Volume 12.25 | Jul 8 2021

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    2021-07-08 | ECM 12.25


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.25 – 8 July, 2021
    TOP STORY

    Astrocytes Close the Mouse Critical Period for Visual Plasticity

    Scientists showed that in the mouse visual cortex, astrocytes controlled critical-period closure. They uncovered the underlying pathway, which involved astrocytic regulation of the ECM, allowing interneuron maturation.
    [Science]

    AbstractPress Release

    Explore scientific events this July with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    Matrix Lumican Endocytosed by Immune Cells Controls Receptor Ligand Trafficking to Promote TLR4 and Restrict TLR9 in Sepsis

    Researchers demonstrated that lumican, an ECM protein normally associated with collagens, was elevated in sepsis patients’ blood, while lumican-null mice resolved polymicrobial sepsis poorly, with reduced bacterial clearance and greater body weight loss.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Let-7b-5p in Vesicles Secreted by Human Airway Cells Reduces Biofilm Formation and Increases Antibiotic Sensitivity of P. aeruginosa

    The authors demonstrated that interdomain communication through small RNA–containing membrane vesicles was bidirectional and that miRNAs in extracellular vesicles secreted by human airway epithelial cells regulated protein expression, antibiotic sensitivity, and biofilm formation by P. aeruginosa.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    High-Dimensional and Single-Cell Transcriptome Analysis of the Tumor Microenvironment in Angioimmunoblastic T Cell Lymphoma (AITL)

    Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the AITL tumor microenvironment.
    [Leukemia]

    Abstract

    Breast Tumor Stiffness Instructs Bone Metastasis via Maintenance of Mechanical Conditioning

    Fibrotic-like matrix stiffness promoted distinct metastatic phenotypes in breast cancer cells, which were preserved after transition to softer microenvironments, such as bone marrow.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Targeting HIF-Activated Collagen Prolyl 4-Hydroxylase Expression Disrupts Collagen Deposition and Blocks Primary and Metastatic Uveal Melanoma Growth

    Investigators demonstrated that extracellular collagen matrix formation could be targeted in uveal melanoma by inhibiting hypoxia-induced P4HA1 and P4HA2 expression, warranting further development of this strategy in patients with uveal melanoma.
    [Oncogene]

    Abstract

    Sodium Alginate/Collagen/Stromal Cell-Derived Factor-1 Neural Scaffold Loaded with BMSCs Promotes Neurological Function Recovery after Traumatic Brain Injury

    The authors synthesized a sodium alginate (SA)/collagen type I (Col)/stromal cell-derived factor-1 (SDF-1) hydrogel and investigated whether the SA/Col/SDF-1 hydrogel loaded with bone marrow-derived mesenchymal stem cells (BMSCs) had therapeutic effects on a traumatic brain injury model.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Identification of Essential Genes for Escherichia coli Aryl Polyene Biosynthesis and Function in Biofilm Formation

    Researchers highlighted key steps in the aryl polyene biosynthesis pathway that could be explored as potential drug targets for complementary strategies to reduce fitness and prevent biofilm formation of multi-drug resistant pathogens.
    [npj Biofilms and Microbiomes]

    Full Article

    Dysregulated ECM Remodeling Proteins Lead to Aberrant Osteogenesis of Costello Syndrome iPSCs

    Scientists used Costello syndrome-induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of ECM remodeling proteins contributed to impaired osteogenesis.
    [Stem Cell Reports]

    Full Article

    Single Cell Analysis of Mouse and Human Prostate Reveals Novel Fibroblasts with Specialized Distribution and Microenvironment Interactions

    Using single-cell RNA-sequencing, investigators identified and validated the in situ localization of three smooth muscle subtypes and two novel fibroblast subtypes in human prostate.
    [Journal of Pathology]

    Abstract

    Patient-Derived Scaffolds as a Drug-Testing Platform for Endocrine Therapies in Breast Cancer

    A patient-derived scaffold model was evaluated as a testing platform for the endocrine therapies (Z)-4-Hydroxytamoxifen and fulvestrant as well as the CDK4/6-inhibitor palbociclib, monitoring the treatment responses in breast cancer cell lines MCF7 and T47D adapted to the patient-based microenvironments.
    [Scientific Reports]

    Full Article

    Five tips for returning to the lab after time off
    REVIEWS

    B Cell Heterogeneity, Plasticity, and Functional Diversity in Cancer Microenvironments

    Scientists describe the multidimensional interplays between B cells and other immune cells in the tumor microenvironment, which account for the regulation of B cell differentiation and function in situ.
    [Oncogene]

    Abstract

    INDUSTRY AND POLICY NEWS

    RepliCel Applies for Manufacturing Approval for its Collagen and Tissue Regeneration Cell Therapies

    RepliCel Life Sciences, Inc. announced it has submitted its application to Japan’s Ministry of Health, Labour, and Welfare for approval to manufacture the company’s RCT-01 cell therapy for chronic tendinopathy and RCS-01 cell therapy for aging and sun-damaged skin for its upcoming clinical studies.
    [RepliCel Life Sciences, Inc.]

    Press Release

    Histogen Announces Initiation of HST 003 Phase I/II Trial for Knee Cartilage Regeneration

    Histogen Inc. has announced the initiation of its Phase I/II clinical trial of HST 003 to evaluate the safety and efficacy of human ECM implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline cartilage in combination with a microfracture procedure.
    [Histogen Inc.]

    Press Release

    FEATURED EVENT

    Biointerfaces International

    August 18 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Training Fellow – Organ Morphodynamics

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Research Associate – Bio-Engineered Alzheimer’s Disease

    North Carolina A&T State University – Greensboro, North Carolina, United States

    Editor – Nature Materials

    Springer Nature – Multiple Locations

    Chief Scientific Officer – Fibroblasts and Stem Cells

    FibroBiologics – Houston, Texas, United States

    Postdoctoral Positions – Cellular, Molecular and Digital Medicine

    Research Center for Molecular Medicine – Vienna, Austria

    > See All Jobs

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