Extracellular Matrix News Volume 12.27 | Jul 22 2021

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    2021-07-22 | ECM 12.27


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.27 – 22 July, 2021
    TOP STORY

    Erythropoietin Promotes Abdominal Aortic Aneurysms in Mice through Angiogenesis and Inflammatory Infiltration

    Researchers found that erythropoietin (EPO) promoted the formation of abdominal aortic aneurysm (AAA) in both Apoe−/− and wild type mice by enhancing angiogenesis, inflammation, collagen degradation, and apoptosis of smooth muscle cells and that EPO/EPO receptor signaling was essential for angiotensin II-induced AAA.
    [Science Translational Medicine]

    Abstract

    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Tumor Microenvironment Chip Evaluates the Consequences of Platelet Extravasation and Combinatorial Antitumor-Antiplatelet Therapy in Ovarian Cancer

    The authors created an ovarian tumor microenvironment chip that consisted of a platelet-perfused tumor microenvironment and recapitulated platelet extravasation and its consequences.
    [Science Advances]

    Full Article

    Myofibroblast Transcriptome Indicates SFRP2hi Fibroblast Progenitors in Systemic Sclerosis Skin

    Researchers showed that systemic sclerosis skin dermal myofibroblasts arose in two steps from an SFRP2hi/DPP4-expressing progenitor fibroblast population.
    [Nature Communications]

    Full Article

    Role of Matrix Metalloproteinase-9 in Neurodevelopmental Disorders and Plasticity in Xenopus Tadpoles

    Investigators tested the hypothesis that chronically elevated matrix metalloproteinase-9 activity during early neurodevelopment was responsible for neural circuit hyperconnectivity observed in Xenopus tadpoles after early exposure to valproic acid.
    [eLife]

    Abstract

    Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage

    Scientists defined differences in cortical actin content associated with differential expression of actin regulating proteins, suggesting that differences in adhesome expression were associated with differences in cortical actin homeostasis.
    [Journal of Immunology]

    Abstract

    ASIC1a Promotes the Proliferation of Synovial Fibroblasts via the ERK/MAPK Pathway

    Rats induced with adjuvant arthritis and human primary synovial fibroblasts were used in vivo and in vitro to investigate the role of acid-sensing ion channel 1a (ASIC1a) in the proliferation of rheumatoid arthritis synovial fibroblasts.
    [Laboratory Investigation]

    Abstract

    Ten-Gene Signature Reveals the Significance of Clinical Prognosis and Immuno-Correlation of Osteosarcoma and Study on Novel Skeleton Inhibitors Regarding MMP9

    The authors identified novel targets in the carcinogenesis, therapy, and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9.
    [Cancer Cell International]

    Full Article

    Endotrophin and C6Ma3, Serological Biomarkers of Type VI Collagen Remodeling, Reflect Endoscopic and Clinical Disease Activity in IBD

    Scientists investigated if remodeling of the intestinal basement membrane type VI collagen was associated with pathophysiological changes in Crohn’s disease and ulcerative colitis.
    [Scientific Reports]

    Full Article

    Tumor Microenvironment in Giant Cell Tumor of Bone: Evaluation of PD-L1 Expression and SIRPα Infiltration after Denosumab Treatment

    The authors focused on potential immunotherapy for giant cell tumor of bone (GCTB) and investigated the tumor microenvironment of GCTB.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Fibroblasts: Origins, Definitions, and Functions in Health and Disease

    Investigators summarize fibroblast development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart.
    [Cell]

    Full Article

    The Translational Application of Hydrogel for Organoid Technology: Challenges and Future Perspectives

    Recently, synthetic polymeric hydrogels, with high biocompatibility and biodegradability, stability, uniformity of compositions, and high throughput properties, have emerged as potential materials for achieving 3D architectures for organoid cultures.
    [Macromolecular Bioscience]

    Abstract

    INDUSTRY AND POLICY NEWS

    Eluminex Biosciences Exclusively Licenses FibroGen’s Biosynthetic Cornea Technology and Recombinant Collagen III Platform

    Eluminex Biosciences Limited announced that it has exclusively licensed global rights for the development and commercialization of an investigational biosynthetic cornea derived from recombinant human collagen Type III intended to treat patients with corneal blindness, from FibroGen, Inc.
    [FibroGen, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Vascular Malformations: From Fundamental Biology to Therapeutic Opportunities

    October 6 – 8, 2021
    Online and Badalona, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Cancer Research Experimental Therapies

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Associate – Extracellular Matrix and Inflammation

    Baylor College of Medicine – Houston, Texas, United States

    Associate/Assistant Professor – Pharmacology and Physiology

    University of Rochester – Rochester, New York, United States

    Research Assistant – Pediatric Neuroscience Research

    Oregon Health & Science University – Portland, Oregon, United States

    Postdoctoral Training Fellow – Organ Morphodynamics

    Francis Crick Institute – London, England, United Kingdom

    > See All Jobs

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