| Vol. 12.27 – 22 July, 2021 |
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| Researchers found that erythropoietin (EPO) promoted the formation of abdominal aortic aneurysm (AAA) in both Apoe−/− and wild type mice by enhancing angiogenesis, inflammation, collagen degradation, and apoptosis of smooth muscle cells and that EPO/EPO receptor signaling was essential for angiotensin II-induced AAA. [Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors created an ovarian tumor microenvironment chip that consisted of a platelet-perfused tumor microenvironment and recapitulated platelet extravasation and its consequences. [Science Advances] |
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| Researchers showed that systemic sclerosis skin dermal myofibroblasts arose in two steps from an SFRP2hi/DPP4-expressing progenitor fibroblast population. [Nature Communications] |
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| Investigators tested the hypothesis that chronically elevated matrix metalloproteinase-9 activity during early neurodevelopment was responsible for neural circuit hyperconnectivity observed in Xenopus tadpoles after early exposure to valproic acid. [eLife] |
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| Scientists defined differences in cortical actin content associated with differential expression of actin regulating proteins, suggesting that differences in adhesome expression were associated with differences in cortical actin homeostasis. [Journal of Immunology] |
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| Rats induced with adjuvant arthritis and human primary synovial fibroblasts were used in vivo and in vitro to investigate the role of acid-sensing ion channel 1a (ASIC1a) in the proliferation of rheumatoid arthritis synovial fibroblasts. [Laboratory Investigation] |
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| The authors identified novel targets in the carcinogenesis, therapy, and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds with potential inhibition regarding MMP-9. [Cancer Cell International] |
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| Scientists investigated if remodeling of the intestinal basement membrane type VI collagen was associated with pathophysiological changes in Crohn’s disease and ulcerative colitis. [Scientific Reports] |
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| The authors focused on potential immunotherapy for giant cell tumor of bone (GCTB) and investigated the tumor microenvironment of GCTB. [Scientific Reports] |
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| Investigators summarize fibroblast development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart. [Cell] |
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| Recently, synthetic polymeric hydrogels, with high biocompatibility and biodegradability, stability, uniformity of compositions, and high throughput properties, have emerged as potential materials for achieving 3D architectures for organoid cultures. [Macromolecular Bioscience] |
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| Eluminex Biosciences Limited announced that it has exclusively licensed global rights for the development and commercialization of an investigational biosynthetic cornea derived from recombinant human collagen Type III intended to treat patients with corneal blindness, from FibroGen, Inc. [FibroGen, Inc.] |
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| October 6 – 8, 2021 Online and Badalona, Spain |
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| Cedars-Sinai – Los Angeles, California, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Rochester – Rochester, New York, United States |
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| Oregon Health & Science University – Portland, Oregon, United States |
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| Francis Crick Institute – London, England, United Kingdom |
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