| Vol. 12.28 – 29 July, 2021 |
| |
|
|
| To explore the key ECM proteins in the maintenance of the contractile phenotype of vascular smooth muscle cells (VSMCs), investigators applied protein-protein interaction network analysis to explore novel ECM proteins associated with the VSMC phenotype. [Circulation] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists demonstrated that THAP1 modulated the ECM composition by regulating glycosaminoglycan catabolism within oligodendrocyte progenitor cells. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage. [Stem Cell Research & Therapy] |
|
|
|
| Investigators reported on the fabrication and characterization of electrospun of carboxymethyl guargum, reduced graphene oxide nanocomposite dressings loaded with curcumin for chronic wound healing applications. [International Journal of Pharmaceutics] |
|
|
|
| In vitro, researchers found that 3D collagen culture promoted the capability of colony formation and growth in integrin β1 (integrin β1) positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression. [Aging] |
|
|
|
| Scientists investigated the beneficial effects of exosomes derived from bone marrow mesenchymal stem cells on trabecular meshwork cells under oxidative stress and predicted candidate genes associated with this process. [Scientific Reports] |
|
|
|
| The authors found that the stimulation of human trabecular meshwork (TM) cells with monocyte chemoattractant protein (MCP)-1 and IL-8 induced significant increase in the formation of actin stress fibers and focal adhesions, myosin light chain phosphorylation, and the contraction of TM cells. [Scientific Reports] |
|
|
|
| Investigators studied the possible role and mechanism of angiomotin-like 2 (AMOTL2) in regulating transforming growth factor-β1 (TGF-β1)-induced proliferation and extracellular matrix (ECM) deposition of airway smooth muscle cells. [Environmental Toxicology] |
|
|
|
| In H&E stained muscle sections, the relative fractions of muscle vs extracellular matrix were determined. [Journal of Applied Physiology] |
|
|
|
|
| The authors summarize the contribution of biomaterials to wound healing and skin regeneration and addresses the existing limitations in skin grafting. [Small] |
|
|
|
| The authors discuss approaches adopted to recapitulate complex tumor biology in tractable 3D models. They consider how these cell types can be sourced and combined and examine methods for the deconvolution of complex multicellular models into manageable and informative outputs. [Trends in Cancer] |
|
|
|
| Investigators present three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic self-complementary peptides, amphiphilic peptides, and triple-helix peptides. [Bio-Design and Manufacturing] |
|
|
|
|
| The American Thoracic Society (ATS) Research Program and the American Lung Association have awarded Laurie Eldredge, MD, PhD, of the University of Washington/Seattle Children’s Hospital a $100,000 Partner Grant. The ATS Research Program Partner Grants provide crucial support to talented investigators from around the world, launching careers dedicated to scientific discovery and better patient care. [ATS Research Program (Newswise, Inc.)] |
|
|
|
| The American Association for Dental Research (AADR) announced Martha Somerman, National Institutes of Health, Bethesda, Md., as the 2021 recipient of the AADR Jack Hein Public Service Award. Somerman began her dental research career analyzing links between vitamin D and bone remodeling and continued research of mineralized tissues characterizing ECM proteins from bone and their bioactive effects on osteoblasts and osteoclasts in culture. [International & American Associations For Dental Research (EurkAlert!)] |
|
|
|
|
| November 22 – 23, 2021 Ghent, Belgium |
|
|
|
|
|
| Oregon Health & Science University – Portland, Oregon, United States |
|
|
|
| University of Rochester – Rochester, New York, United States |
|
|
|
| Cedars-Sinai – Los Angeles, California, United States |
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| University of Rochester – Rochester, New York, United States |
|
|
|
|