Extracellular Matrix News Volume 12.28 | Jul 29 2021

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    2021-07-29 | ECM 12.28


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.28 – 29 July, 2021
    TOP STORY

    Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling

    To explore the key ECM proteins in the maintenance of the contractile phenotype of vascular smooth muscle cells (VSMCs), investigators applied protein-protein interaction network analysis to explore novel ECM proteins associated with the VSMC phenotype.
    [Circulation]

    Abstract
    Explore scientific events this August with the Science Events Calendar.
    PUBLICATIONSRanked by the impact factor of the journal

    THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes

    Scientists demonstrated that THAP1 modulated the ECM composition by regulating glycosaminoglycan catabolism within oligodendrocyte progenitor cells.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Extracellular Vesicles Derived from LPS-Preconditioned Human Synovial Mesenchymal Stem Cells Inhibit Extracellular Matrix Degradation and Prevent Osteoarthritis of the Knee in a Mouse Model

    Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage.
    [Stem Cell Research & Therapy]

    Full Article

    Bioengineering for Curcumin Loaded Carboxymethyl Guargum /Reduced Graphene Oxide Nanocomposites for Chronic Wound Healing Applications

    Investigators reported on the fabrication and characterization of electrospun of carboxymethyl guargum, reduced graphene oxide nanocomposite dressings loaded with curcumin for chronic wound healing applications.
    [International Journal of Pharmaceutics]

    AbstractGraphical Abstract

    Type I Collagen Promotes Tumor Progression of Integrin β1 Positive Gastric Cancer through a BCL9L/β-Catenin Signaling Pathway

    In vitro, researchers found that 3D collagen culture promoted the capability of colony formation and growth in integrin β1 (integrin β1) positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression.
    [Aging]

    Full Article

    Mesenchymal Stem Cell-Derived Exosomes Protect Trabecular Meshwork from Oxidative Stress

    Scientists investigated the beneficial effects of exosomes derived from bone marrow mesenchymal stem cells on trabecular meshwork cells under oxidative stress and predicted candidate genes associated with this process.
    [Scientific Reports]

    Full Article

    Role of MCP-1 and IL-8 in Viral Anterior Uveitis, and Contractility and Fibrogenic Activity of Trabecular Meshwork Cells

    The authors found that the stimulation of human trabecular meshwork (TM) cells with monocyte chemoattractant protein (MCP)-1 and IL-8 induced significant increase in the formation of actin stress fibers and focal adhesions, myosin light chain phosphorylation, and the contraction of TM cells.
    [Scientific Reports]

    Full Article

    AMOTL2 Restrains Transforming Growth Factor-β1-Induced Proliferation and Extracellular Matrix Deposition of Airway Smooth Muscle Cells via the Down-Regulation of YAP1 Activation

    Investigators studied the possible role and mechanism of angiomotin-like 2 (AMOTL2) in regulating transforming growth factor-β1 (TGF-β1)-induced proliferation and extracellular matrix (ECM) deposition of airway smooth muscle cells.
    [Environmental Toxicology]

    Abstract

    Tongue Muscle Contractile, Fatigue and Fiber Type Properties in Rats

    In H&E stained muscle sections, the relative fractions of muscle vs extracellular matrix were determined.
    [Journal of Applied Physiology]

    Abstract
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Engineering Bioactive Scaffolds for Skin Regeneration

    The authors summarize the contribution of biomaterials to wound healing and skin regeneration and addresses the existing limitations in skin grafting.
    [Small]

    Abstract

    Tumor Microenvironment 3D-Modeling: Simplicity to Complexity and Back Again

    The authors discuss approaches adopted to recapitulate complex tumor biology in tractable 3D models. They consider how these cell types can be sourced and combined and examine methods for the deconvolution of complex multicellular models into manageable and informative outputs.
    [Trends in Cancer]

    Abstract

    Recent Advances in Design and Applications of Biomimetic Self-Assembled Peptide Hydrogels for Hard Tissue Regeneration

    Investigators present three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic self-complementary peptides, amphiphilic peptides, and triple-helix peptides.
    [Bio-Design and Manufacturing]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Dr. Laurie Eldredge Receives ATS Research Program/American Lung Association Partner Gran

    The American Thoracic Society (ATS) Research Program and the American Lung Association have awarded Laurie Eldredge, MD, PhD, of the University of Washington/Seattle Children’s Hospital a $100,000 Partner Grant. The ATS Research Program Partner Grants provide crucial support to talented investigators from around the world, launching careers dedicated to scientific discovery and better patient care.
    [ATS Research Program (Newswise, Inc.)]

    Press Release

    Martha Somerman Named 2021 Recipient of the AADR Jack Hein Public Service Award

    The American Association for Dental Research (AADR) announced Martha Somerman, National Institutes of Health, Bethesda, Md., as the 2021 recipient of the AADR Jack Hein Public Service Award. Somerman began her dental research career analyzing links between vitamin D and bone remodeling and continued research of mineralized tissues characterizing ECM proteins from bone and their bioactive effects on osteoblasts and osteoclasts in culture.
    [International & American Associations For Dental Research (EurkAlert!)]

    Press Release
    FEATURED EVENT

    Translational Immunology

    November 22 – 23, 2021
    Ghent, Belgium

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Molecular Mechanisms in White Matter

    Oregon Health & Science University – Portland, Oregon, United States

    Associate Professor – Cell Signaling

    University of Rochester – Rochester, New York, United States

    Research Associate – Cancer Research Experimental Therapies

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Associate – Extracellular Matrix and Inflammation

    Baylor College of Medicine – Houston, Texas, United States

    Associate/Assistant Professor – Pharmacology and Physiology

    University of Rochester – Rochester, New York, United States

    > See All Jobs

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