 | | Vol. 12.29 – 5 August, 2021 |
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| The authors showed that the conversion of stem-like into effector-like cytotoxic T lymphocyte involved a major chemotactic reprogramming that included the upregulation of chemokine receptor CXCR6.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that anti–cytotoxic T lymphocyte–associated protein 4 (CTLA-4)×SIRPα preferentially depleted ICOShigh immunosuppressive Treg cells in the tumor microenvironment and enhanced immunity against solid tumors, including MC38 and CT26 murine colon cancers.
[Science Translational Medicine] |
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| Researchers reported biological features of invasive growth accompanying tumor progression and invasion based on associated metabolic and transcriptomic changes observed in patient derived orthotopic xenografts in the mouse and the corresponding patients’ tumors.
[Acta Neuropathologica] |
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| Investigators showed that the variable memory of local cell density experienced by a mother cell controls the levels of the cyclin-dependent kinase activator cyclin D1 and inhibitor p27 in newborn daughters, which directed cells to proliferation or quiescence.
[Cell Reports] |
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| The authors proposed to infuse a degradable RGD-functionalized alginate matrix with osteoid-like stiffness, as an artificial ECM, to a rigid 3D-printed hydroxyapatite scaffold for maxillofacial regeneration.
[Journal of Dental Research] |
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| Investigators analyzed the role of dietary salt in TNBS chronic colitis induced in rat, an intestinal fibrosis model, and in human colon fibroblast cells and showed that high-salt diet exacerbated undernutrition and promoted ECM-associated proteins in fibroblasts.
[Scientific Reports] |
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| Scientists showed that Kv1.3-deficient platelets displayed enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin αIIb.
[Platelets] |
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| Researchers provide a recent insight into the role of the key inflammatory cells infiltrating the tumor microenvironment, with a focus on reviewing immunological principles related to HNSCC, as cancer immunosurveillance and immune escape.
[International Journal of Oral Science] |
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| Investigators developed a mechanically active adhesive and immune regulative dressin, mainly consisting of temperature-sensitive hydrogel with semi-interpenetrating network structure.
[Matter] |
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| The authors discuss the immunostimulatory and immunosuppressive roles of interleukin-10 (IL-10) in the glioblastoma tumour microenvironment while considering IL-10-targeted treatment strategies.
[British Journal of Cancer] |
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| Jeune Aesthetics, Inc. announced the initiation of dosing in the efficacy cohort of the PEARL-1 trial, a Phase I multi-dose, controlled clinical study of KB301 to assess improvement of skin quality.
[Jeune Aesthetics, Inc. (GlobeNewswire, Inc.)] |
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| September 28 -30, 2021
Virtual |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | University of Rochester – Rochester, New York, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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