Extracellular Matrix News Volume 12.31 | Aug 19 2021

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    2021-08-19 | ECM 12.31


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.31 – 19 August, 2021
    TOP STORY

    Microsphere Embedded Hydrogel Construct – Binary Delivery of Alendronate and BMP-2 for Superior Bone Regeneration

    A microsphere embedded osteoinductive decellularized bone ECM/oleoyl chitosan based hydrogel construct was developed as a matrix allowing dual delivery of an anti-resorptive drug and BMP-2 for a focal tibial defect in a rabbit model. Amniotic membrane-derived stem cells cultivated on the hydrogel construct demonstrated excellent biocompatibility, cell viability, and active proliferation potential.
    [Journal of Materials Chemistry B]

    AbstractGraphical Abstract

    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Percolation of Collagen Stress in a Random Network Model of the Alveolar Wall

    Investigators developed a network model of randomly oriented collagen and elastin fibers to represent pulmonary alveolar wall tissue.
    [Scientific Reports]

    Full Article

    Integrated Computational and Experimental Pipeline for Quantifying Local Cell–Matrix Interactions

    Researchers presented an image analysis platform to analyze time-dependent dynamics observed in lung fibroblasts embedded in a 3D collagen matrix.
    [Scientific Reports]

    Full Article

    A Collagen-Silica-Based Biocomposite for Potential Application in Bone Tissue Engineering

    The authors synthesized and performed the physicochemical characterization and biocompatibility of a collagen-silica-based biocomposite for potential application in bone tissue engineering.
    [Journal of Biomedical Materials Research Part A]

    Abstract

    Sequence-Dependent Mechanics of Collagen Reflect Its Structural and Functional Organization

    Scientists used atomic force microscopy to determine the impact of sequence heterogeneity on the local flexibility of collagen IV and of the fibril-forming collagen III.
    [Biophysical Journal]

    Abstract

    Tissue-Engineered Esophagus: Recellular Esophageal Extracellular Matrix Based on Perfusion-Decellularized Technique and Mesenchymal Stem Cells

    In this study, the esophageal extracellular matrix scaffold was successfully constructed by perfusion-decellularized technique through the vascular system for the first time.
    [Biomedical Materials]

    Abstract

    Differential Effects of Rat ADSCs Encapsulation in Fibrin Matrix and Combination Delivery of BDNF and Gold Nanoparticles on Peripheral Nerve Regeneration

    The inner surface of electrospun poly nanofibrous conduit was biofunctionalized with laminin containing brain derived neurotrophic factor (BDNF) and gold nanoparticles in chitosan nanoparticle.
    [BMC Neuroscience]

    Full Article

    VX-765 Ameliorates Inflammation and Extracellular Matrix Accumulation by Inhibiting the NOX1/ROS/NF-κB Pathway in Diabetic Nephropathy

    Researchers explored the potential role of a highly selective caspase-1 inhibitor, VX-765, on extracellular matrix accumulation and inflammation in diabetic nephropathy and the underlying mechanisms.
    [Journal of Pharmacy and Pharmacology]

    Abstract

    Lysine-Specific Demethylase 1 Induced Epithelial-Mesenchymal Transition and Promoted Renal Fibrosis through Jagged-1/Notch Signaling Pathway

    Lysine-specific demethylase 1 significantly impacted on the progression of TGF-β1-mediated epithelial-mesenchymal transition and ECM deposition in HK-2 cells, and it may represent novel target for the prevention strategies of renal fibrosis.
    [Human & Experimental Toxicology]

    Abstract

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    REVIEWS

    The Role of Basement Membranes in Cardiac Biology and Disease

    The authors bring together emerging understanding of basement membrane defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed.
    [Bioscience Reports]

    Abstract
    Full Article

    INDUSTRY AND POLICY NEWS

    Orizuru Therapeutics Launches Operations as Research and Development-Driven Company for Products including Induced Pluripotent Stem Cell (iPSC) Regenerative Medicine

    Orizuru Therapeutics, Inc. (OZTx) announced the launch of its operations. OZTx is a research and development-driven company focusing on the development of iPSC-based regenerative medicine and the application of iPSC technology.
    [Orizuru Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    The Matrix In Focus: Matrix, Cells, and Interactions in Health, Disease, Aging, and Regeneration

    September 12 – 15, 2021
    St. Louis, Missouri, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Protein Engineering

    Revel Pharmaceuticals – San Francisco, California, United States

    Research Associate – Stem Cell Models

    Michigan State University – East Lansing, Michigan, United States

    Principal Medical Scientist – Oncology

    Gilead Sciences, Inc. – Foster City, California, United States

    Development Engineer – Cell Therapies and Regenerative Medicine

    Danaher – Toronto, Ontario, Canada

    Postdocotral Fellow – Liquid Chromatography-Mass Spectrometry

    Buck Institute for Research on Aging – Novato, California, United States

    > See All Jobs

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