Extracellular Matrix News Volume 12.33 | Sep 2 2021

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    2021-09-02 | ECM 12.33


    Extracellular Matrix News by STEMCELL Technologies
    Vol. 12.33 – 2 September, 2021
    TOP STORY

    Pro-Inflammatory Immunity Supports Fibrosis Advancement in Epidermolysis Bullosa: Intervention with Ang-(1–7)

    Longitudinal analyses of the tissue proteome through the course of naturally developing disease in recessive dystrophic epidermolysis bullosa mice revealed that increased pro-inflammatory immunity associates with fibrosis evolution.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    The STEMdiff™ Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.
    PUBLICATIONSRanked by the impact factor of the journal

    Combining Bone Collagen Matrix with hUC-MSCs for Application to Alveolar Process Cleft in a Rabbit Model

    A rabbit alveolar process cleft model was established by removing the bone tissue from the left maxillary bone. 48 young Japanese white rabbits were divided into normal, control, material and mesenchymal stem cell groups.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Unraveling the Extracellular Matrix-Tumor Cell Interactions to Aid Better Targeted Therapies for Neuroblastoma

    Researchers established through a clinical cohort and preclinical models that the interaction of vitronectin and its ligands, such as αv integrins, were related to the stiffness of the ECM in high-risk neuroblastoma.
    [International Journal of Pharmaceutics]

    Abstract

    Serum Matrix Metalloproteinase 7 and Accelerated GFR Decline in a General Non-Diabetic Population

    Scientists investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1, were associated with glomerular filtration rate decline in a general nondiabetic population.
    [Nephrology Dialysis Transplantation]

    AbstractGraphical Abstract

    A Matrix Metalloproteinase-Generated Neoepitope of CRP Can Identify Knee and Multi-Joint Inflammation in Osteoarthritis

    The authors compared C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis.
    [Arthritis Research & Therapy]

    Full Article

    A Fructosylated Peptide Derived from a Collagen II T Cell Epitope for Long-Term Treatment of Arthritis (FIA-CIA) in Mice

    Researchers investigated arthritis development in male DBA/1 mice which were injected with bovine collagen II and human fibrinogen on days 0 and 21, leading to stable and reproducible disease induction in 100% of immunized mice.
    [Scientific Reports]

    Full Article

    Heterogeneity in Proline Hydroxylation of Fibrillar Collagens Observed by Mass Spectrometry

    Investigators sampled four different collagen samples using standard mass spectrometry (MS) and MS/MS techniques.
    [PLOS One]

    Full Article

    Intestinal Organoid-Based 2D Monolayers Mimic Physiological and Pathophysiological Properties of the Pig Intestine

    3D Organoids were grown in an extracellular matrix and characterized by qPCR. Organoids were also seeded on permeable filter supports in order to generate 2D epithelial monolayers.
    [PLoS One]

    Full Article

    Decreased Levels of Endocytic Collagen Receptor Endo180 in Dermal Fibroblasts Lead to Decreased Production of Type I Collagen and Increased Expression of Matrix Metalloproteinase-1

    Investigators clarified the relationship between Endo180 reduction and the decrease in type I collagen fibers observed in photoaged dermis.
    [Photodermatology, Photoimmunology & Photomedicine]

    Abstract

    Explore scientific events this September with the Science Events Calendar.
    REVIEWS

    Engineered Living Biomaterials

    Scientists discuss engineered living materials that incorporate microorganisms as the living, bioactive component. They highlight biomedical applications of such engineered living materials, including biosensing, wound healing, stem-cell-based tissue engineering and drug delivery, and provide an outlook to the challenges and future applications of engineered living materials.
    [Nature Reviews Materials]

    Abstract

    Extracellular Matrix and Oxidative Stress Following Traumatic Spinal Cord Injury: Physiological and Pathophysiological Roles and Opportunities for Therapeutic Intervention

    The authors survey the complexity involved in spinal ECM modifications, discuss new ECM-based combinatorial strategies, and explore biomaterials evaluated in clinical trials which hope to introduce new treatments that enhance recovery after spinal cord injury.
    [Antioxidants & Redox Signaling]

    Abstract

    INDUSTRY AND POLICY NEWS

    University of Miami Researchers Enter Phase III of Stem Cell Clinical Trial in Treating COVID-19 Acute Respiratory Distress Syndrome

    A University of Miami Miller School of Medicine research team has launched a Phase III multicenter clinical trial to evaluate the effectiveness of mesenchymal stem cells in treating COVID-19 patients with acute respiratory distress syndrome.
    [University of Miami]

    Press Release

    Orthofix Announces US Launch and First Patient Implants with New fiberFUSE Strip – An Advanced Fiber Bone-Graft Solution Containing Cancellous Bone

    Orthofix Medical, Inc. announced the launch and first patient implants with the fiberFUSE™ Strip, an advanced demineralized fiber bone-graft solution containing cancellous bone. The fiberFUSE Strip is formulated as a convenient preformed bone-graft strip to enable optimized application for posterior cervical, posterior lumbar and degenerative spinal procedures.
    [Orthofix Medical, Inc.]

    Press Release

    FEATURED EVENT

    AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

    October 7 – 11, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Senior Researcher – Genomic and Epigenetic Changes of Rare Tumors

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Research Fellow – Microfluidic Models of Microvasculature

    University College London – London, England, United Kingdom

    Faculty Positions – Cancer Research

    Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States

    Postdoctoral Associate – Tumor Microenvironment

    Duke University – Durham, North Carolina, United States

    Research Associate – Stem Cell Models

    Michigan State University – East Lansing, Michigan, United States

    > See All Jobs

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