 | | Vol. 12.34 – 9 September, 2021 |
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| Researchers reported highly water soluble, biocompatible and easily accessible poly-DL-serine hydrogels that caused negligible inflammatory response after subcutaneous implantation in mice for one week and two weeks.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors engineered alginate hydrogels to present integrin- and syndecan-binding peptides alone or in combination to introduce bioactive features into the alginate gels.
[Biomaterials] |
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| Scientists showed that NMUR2 activation induced signaling in colorectal cancer (CRC) cells and that NMU increased the motility and invasiveness of NMUR2-positive CRC cells and increased prometastatic integrin receptor subunit expression.
[Journal of Experimental & Clinical Cancer Research] |
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| A thermosensitive acellular extracellular matrix hydrogel coupled with adipose-derived mesenchymal stem cell (ADSC) exosomes that inherited the superior properties of nucleus pulposus tissue and ADSCs was fabricated to ameliorate intervertebral disc degeneration.
[Journal of Nanobiotechnology] |
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| Researchers demonstrated that collagen-induced discoid domain receptor 1 (DDR1) activation in cancer cells was a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils, the formation of neutrophil extracellular traps, and subsequent cancer cell invasion and metastasis.
[JCI Insight] |
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| Scientists described the adjuvant properties of a small molecule activator of the integrins αLβ2 and α4β1, named 7HP349, which could be safely delivered systemically independent of antigen.
[npj Vaccines] |
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| Investigators examined mice in which integrin α5 was replaced with the α5/2 chimera, using the transverse aortic constriction and partial carotid ligation models of vessel remodeling.
[Journal of the American Heart Association] |
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| Researchers employed a collagen II peptide library to characterize high-affinity binding sites for HSP47. They showed that many previously predicted binding sites have very low affinities due to the presence of a negatively charged amino acid in the binding motif.
[Journal of Biological Chemistry] |
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| The authors explored the correlations between hyaluronic acid (HA) concentration versus mast cell proteases, or matrix metalloproteinase-2/9 and investigated the association of mast cell-specific proteases with disrupted synovial HA homeostasis in rheumatoid arthritis or collagen-induced arthritis rats.
[Immunologic Research] |
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| Scientists discuss the potential regenerative capacity of the remaining islet cells and the utility of stem cell-derived β-like cells to restore β-cell function and describe tissue engineering approaches that might improve the engraftment, function, and survival of β-cell replacement therapies.
[Lancet Diabetes & Endocrinology] |
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| The author provides a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example.
[Biology Open] |
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| Adaptimmune Therapeutics, plc. announced that it has entered into a strategic collaboration and license agreement with Genentech to develop and commercialize allogeneic cell therapies to treat multiple oncology indications. Adaptimmune will be responsible for developing clinical candidates using its iPSC derived allogeneic platform to produce T-cells.
[Adaptimmune Therapeutics, plc.] |
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| BioRestorative Therapies, Inc. announced that the Japanese Patent Office has issued the company a patent related to its metabolic ThermoStem® Program. Claims granted under the new patent cover methodologies related to brown adipocytes from human brown adipose-derived stem cells.
[BioRestorative Therapies, Inc. (GlobeNewswire, Inc.)] |
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| November 15 – 17, 2021
Virtual |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University College London – London, England, United Kingdom |
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| | Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States |
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| | Duke University – Durham, North Carolina, United States |
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