 | | Vol. 12.36 – 23 September, 2021 |
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| Researchers evaluated matrix metalloproteinase-8 (MMP-8) as a modulator of pathogenic mechanical signaling in pulmonary arterial hypertension (PAH). MMP-8 expression was significantly increased in plasma and pulmonary arteries of pulmonary hypertension (PH) patients compared to controls and induced in the pulmonary vasculature in rodent PH models.
[American Journal of Respiratory and Critical Care Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used 3D weaving, additive manufacturing, and autologous mesenchymal stem cells to create a tissue-engineered, bicomponent implant to restore hip function in a canine hip osteoarthritis model.
[Science Advances] |
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| A cartilage regenerative system was developed based on a chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid containing synovial mesencymal stem cells and recruiting tetrahedral framework nucleic acid injected into the articular cavity.
[Biomaterials] |
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| Investigators demonstrated that the autoimmunity caused by the the Drosophila tuSz1 mutant strain was the result of two mutations: a mutation in the GCS1 gene that disrupted N-glycosylation of ECM proteins covering the fat body, and a mutation in the Drosophila Janus Kinase ortholog that caused precocious activation of hemocytes.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors explored whether high-dose vitamin C (VitC) in combination with oncolytic adenoviruses exhibited a synergistic antitumor effect. Combination therapy with high-dose VitC and oncolytic adenoviruses significantly increased the number of T cells in the tumor microenvironment and promoted the activation of T cells.
[Molecular Therapy] |
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| Researchers reported that gastric cancer (GC)-derived small extracellular vesicles (sEV) were primarily absorbed by Kupffer cells and revealed a previously unidentified regulatory axis initiated by sEV-miR-151a-3p that established a hepatic stemness-permissive niche to support GC-liver metastasis.
[Oncogene] |
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| Decellularized ECM deposited by immortalized cells significantly influenced replicative senescent infrapatellar fat pad-derived stem cells in proliferation and differentiation preference, the effect of which was hinged on the approach of immortalization using either simian virus 40 large T antigen (SV40LT) or human telomerase reverse transcriptase (hTERT).
[Acta Biomaterialia] |
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| Scientists demonstrated a critical role for RNA-binding proteins on chromatin to maintain stem and progenitor cell fate by dictating the expression of specific classes of genes.
[PLoS Biology] |
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| Using SPRY4 gene delivery into healthy and degenerated chondrocytes, investigators elucidated the role of SPRY4 in preventing chondrocyte hypertrophy. In addition to using the human cartilage tissues with the destabilization of the model in Sprague-Dawley rats, the role of SPRY4 in cartilage tissues and chondrocytes was explored through their molecular and histological analysis.
[NPJ Regenerative Medicine] |
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| The authors investigated the role of adipocyte procollagen C-endopeptidase enhancer 2 (Pcpe2) in scavenger receptor class BI (SR-BI)–mediated high-density lipoprotein cholesterol uptake and contributions to adipose lipid storage.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| Researchers evaluated the efficacy of hyaluronic acid (HA) functionalized collagen nanofibers in modulating the pro-healing phenotype expression of macrophages for urethral regeneration.
[Journal of Nanobiotechnology] |
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| The role of FGF21 in the progression of osteoarthritis was investigated in both in vitro and in vivo experiments. In vitro, FGF21 administration alleviated apoptosis, senescence, and ECM catabolism of the chondrocytes induced by tert-butyl hydroperoxide by mediating autophagy flux.
[Cell Death & Disease] |
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| Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.
[Aging] |
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| The authors intertwine research from biological, clinical and medicinal chemistry disciplines to discuss historical and current RGD-binding integrin drug discovery, with an emphasis on small-molecule inhibitors of the αv integrins.
[Nature Reviews Drug Discovery] |
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| Investigators revisit the biological characteristics and functions of infiltrating myeloid cells and discuss the recent advances in immunotherapies targeting infiltrating myeloid cells in glioblastoma.
[Oncogene] |
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| | Dr. Frank Barry has been selected as the new director of the C. Wayne McIlwraith Translational Medicine Institute at Colorado State University. Barry’s research and interests include stem cell biology and the development of cell-based repair strategies for osteoarthritis.
[Colorado State University] |
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| | | October 14, 2021
Wädenswil, Switzerland |
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| | | | | Moores Cancer Center, UC San Diego – San Diego, California, United States |
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| | | University of Southern California – Los Angeles, California, United States |
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| | | Houston Methodist Research Institute – Houston, Texas, United States |
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| | | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | | Duke University – Durham, North Carolina, United States |
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