 | | Vol. 12.38 – 14 October, 2021 |
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| Investigators deconvoluted the human pancreatic tumor microenvironment through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors investigated the profitable effect of carbon nanotubes (CNTs) with a different graphene layer and surface modification on the 3D model of intestinal organoids and demonstrated that CNTs promoted the development of intestinal organoids over time.
[ACS Nano] |
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| Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.
[Nature Communications] |
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| Investigators presented a multimodal -omics platform for the comprehensive study of cell populations in complex tissue, which allowed them to characterize the cells involved in wound healing across both time and space.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers developed a modular, self-assembly system for generation of oligomeric cytotoxic conjugates, capable of FGFR1 clustering, for targeting FGFR1-overproducing cancer cells.
[Journal of Biomedical Science] |
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| Decreased expression of circSPG21 was detected in degenerated nucleus pulposus cells (NPCs), the function of circSPG21 in NPCs was explored and verified, and the downstream target of circSPG21 was investigated.
[Experimental and Molecular Medicine] |
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| Liver SMAD2 phosphorylation was down-regulated in all series with matrix metalloproteinase (MMP) inhibition or knock-out, and MMP-9 inhibition or deletion ameliorated the severity of cirrhosis, portal hypertension, and associated derangements.
[Journal of Cellular and Molecular Medicine] |
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| Researchers reported a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold previously reendothelialized with human umbilical vein endothelial cells.
[Communications Biology] |
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| The authors determined a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and elucidated the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts
[Scientific Reports] |
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| Irbesartan suppressedmonocyte chemoattractant protein-1 (MCP-1) production and the accumulation of Ly6C+CCR2+ monocytes and fibrocytes in the inflamed colon, downregulated the expression of type 1 collagen and matrix metalloproteinase 9 and inhibited the development of intestinal fibrosis and tumors.
[Scientific Reports] |
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| Investigators demonstrated that TGF-β1-stimulated Runx2 acetylation in rat osteoblastic cells. p300, a histone acetyltransferase interacted with Runx2, and it promoted Runx2 acetylation upon TGF-β1-treatment in these cells.
[Biological Chemistry] |
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| The authors shed light on recent advances regarding the direct and indirect crosstalk between cancer-associated fibroblasts (CAFs) and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the tumor microenvironment.
[Molecular Cancer] |
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| Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology that leads to degeneration and regeneration of tendons is not completely understood. Scientists review the current literature pertaining to multi-omics in tendons and the potential of these platforms to improve tendon regeneration.
[NPJ Regenerative Medicine] |
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| The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.
[Journal of Cell Communication and Signaling] |
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| Immune-Onc Therapeutics, Inc. announced that the first patient has been dosed in the company’s first-in-human clinical trial of IO-108, a novel antagonist antibody targeting the myeloid checkpoint Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) for the treatment of solid tumors.
[Immune-Onc Therapeutics, Inc.] |
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| Rhizen Pharmaceuticals AG announced that it has commenced dosing in a Phase II trial to evaluate Tenalisib in patients with locally advanced or metastatic breast cancer.
[Rhizen Pharmaceuticals AG (BusinessNewsWire, Inc.)] |
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| November 1 – 3, 2021
Virtual |
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| | Hong Kong University – Hong Kong, China |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | The International Society for Cell & Gene Therapy – Vancouver, British Columbia, Canada |
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| | Moores Cancer Center, UC San Diego – San Diego, California, United States |
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| | University of Southern California – Los Angeles, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
