Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis Researchers report that Twist1 is capable of promoting the formation of invadopodia, specialized membrane protrusions for extracellular matrix degradation. [Cancer Cell] The Generation of Biomolecular Patterns in Highly Porous Collagen-GAG Scaffolds Using Direct Photolithography Researchers present a benzophenone based direct, photolithographic approach to spatially pattern solution phase biomolecules within collagen-GAG scaffolds and demonstrate creation of a wide range of patterns composed of multiple biomolecular species in a manner independent from scaffold fabrication steps. [Biomaterials] A Proteomic Analysis of Engineered Tendon Formation Under Dynamic Mechanical Loading In Vitro Mechanical loading resulted in a more mature tendon tissue characterized by a firmer tissue texture and densely deposited matrices which formed longitudinally aligned collagen fibers in a highly compact fashion. [Biomaterials] The Use of Laminin Modified Linear Ordered Collagen Scaffolds Loaded with Laminin-Binding Ciliary Neurotrophic Factor for Sciatic Nerve Regeneration in Rats Researchers cross-linked linear ordered collagen scaffold fibers with laminin which is a major component of the extracellular matrix in nervous system. [Biomaterials] Promotion of Skin Regeneration in Diabetic Rats by Electrospun Core-Sheath Fibers Loaded with Basic Fibroblast Growth Factor The results demonstrate the potential use of basic fibroblast growth factor-loaded electrospun fibrous mats to rapidly restore the structural and functional properties of wounded skin for patients with diabetic mellitus. [Biomaterials] Dermatopontin Interacts with Fibronectin, Promotes Fibronectin Fibril Formation, and Enhances Cell Adhesion Results suggest that dermatopontin has an accelerating role in fibroblast cell adhesion to the provisional matrix in the initial stage of wound healing. [J Biol Chem] An Extracellular Matrix, Calmodulin-Binding Protein from Dictyostelium with EGF-Like Repeats That Enhance Cell Motility CyrA is the first extracellular calmodulin-binding protein identified in Dictyostelium and since it is an extracellular matrix protein with EGF-like repeats that enhance cell motility it likely also represents the first matricellular protein identified in a lower eukaryote. [Cell Signal] Designing a Tubular Matrix of Oriented Collagen Fibrils for Tissue Engineering Researchers introduce a novel, straightforward flow processing technique that fabricates a small-diameter tubular matrix constructed of anisotropic collagen fibrils. [Acta Biomater] Syndecan-1 and -4 Differentially Regulate Oncogenic K-ras Dependent Cell Invasion into Collagen Through α2β1 Integrin and MT1-MMP Data demonstrate the existence of a complex interplay between integrin α2β1, MT1-MMP, and syndecans in the invasion of K-ras mutant cells in 3D collagen that may represent a mechanism by which tumor cells become more invasive and metastatic. [Matrix Biol] Collagen VI Is a Basement Membrane Component That Regulates Epithelial Cell-Fibronectin Interactions The data demonstrate that collagen VI is an important basal lamina component involved in the regulation of epithelial cell behavior most notably as a regulator of epithelial cell-fibronectin interactions. [Matrix Biol] Effect of Orientation and Targeted Extracellular Matrix Degradation on Annulus Fibrosus Shear Mechanical Properties The objective of this study was to investigate the effects of tissue orientation and enzymatic degradation of glycosaminoglycan and elastin on annulus fibrosus shear mechanical properties. [J Mech Behav Biomed Mater] |