Quantification of the Forces Driving Self-Assembly of Three-Dimensional Microtissues Whereas the driving force for self-assembly has often been viewed as the binding of surface proteins, these data show that cellular contraction is important for cell-cell adhesion. [Proc Natl Acad Sci U S A] Enhanced Proliferation of Neural Stem Cells in a Collagen Hydrogel Incorporating Engineered Epidermal Growth Factor Collagen-based hydrogels were designed to provide microenvironments for embedded cells to survive and proliferate. [Biomaterials] Type IV Collagen-Initiated Signals Provide Survival and Growth Cues Required for Liver Metastasis Because type IV collagen was the most prominently altered extracellular matrix protein in this model, researchers further analyzed its functional relevance to liver metastasis. [Oncogene] Actomyosin-Generated Tension Controls the Molecular Kinetics of Focal Adhesions Researchers present direct evidence that actomyosin contractility regulates the molecular kinetics of focal adhesions. [J Cell Sci] Hyaluronic Acid-Based Clinical Biomaterials Derived for Cell and Molecule Delivery in Regenerative Medicine For cell therapy and the development of clinical combination products, researchers created a hyaluronan-based synthetic extracellular matrix that provides highly reproducible, manufacturable, approvable, and affordable biomaterials. [J Control Release] Extracellular Matrix Protein Lumican Regulates Inflammation in a Mouse Model of Colitis Researchers investigated the role of lumican in the development of colitis mediated by intrarectal administration of the hapten 2-4-5, trinitrobenzene sulfonic acid in Lum+/+ and Lum−/− mice. [Inflamm Bowel Dis] Effect of Surface Modification on Protein Retention and Cell Proliferation Under Strain Researchers investigate differences in laminin surfaces that were deposited on oxidized polydimethylsiloxane with plasma treatment (plasma only) versus plasma and aminopropyltrimethoxysilane (silane-linked). [Acta Biomater] Different Collagen Types Define Two Types of Idiopathic Epiretinal Membranes Researchers aimed to identify differences in extracellular matrix contents between idiopathic epiretinal membranes of cellophane macular reflex or preretinal macular fibrosis type. [Histopathology] The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cell Osteogenesis A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. [Macromol Biosci] Snail Negatively Regulates Cell Adhesion to Extracellular Matrix and Integrin Expression via the MAPK Pathway in Prostate Cancer Cells Researchers hypothesized that Snail will lead to decreased cellular adhesion to fibronectin and collagen I matrix through integrin regulation, concomitant with increased cell migration. [Cell Adh Migr] |