Nanofibrous Hollow Microspheres Self-Assembled from Star-Shaped Polymers as Injectable Cell Carriers for Knee Repair The nanofibrous hollow microspheres, integrating the extracellular-matrix-mimicking architecture with a highly porous injectable form, were shown to efficiently accommodate cells and enhance cartilage regeneration, compared with control microspheres. [Nat Mater] MicroRNA-18 and -19 Regulate CTGF and TSP-1 Expression in Age-Related Heart Failure Data support a role for cardiomyocyte-derived miR-18/19 during cardiac aging, in the fine-tuning of cardiac extracellular matrix protein levels. [Aging Cell] The Role of Substratum Compliance of Hydrogels on Vascular Endothelial Cell Behavior The impact of substratum compliance on the modulation of cell behaviors of several human primary endothelial cell types, representing different anatomic sites and differentiation states in vivo, were investigated. [Biomaterials] Aligned Hybrid Silk Scaffold for Enhanced Differentiation of Mesenchymal Stem Cells into Ligament Fibroblasts It has been shown in previous studies that cells were guided to align along the topographical alignment of the seeding substrate and produced enhanced amounts of oriented extracellular matrix. In this study, researchers aimed to apply this concept to a three-dimensional full silk fibroin (SF) hybrid scaffold system, which comprised of knitted SF and aligned SF electrospun fibers, for ligament tissue engineering applications. [Tissue Eng Part C Methods] Regional Differences in the Expression of Laminin Isoforms During Mouse Neural Tube Development Findings reveal major differences in basement composition along the body axis, with the rostral neural tube (at mandibular arch and heart levels) exhibiting many distinct laminin variants, while the lumbar level where the neural tube is just closing shows a much simpler laminin profile. [Matrix Biol] A Link Between Smooth Muscle Cell Death and Extracellular Matrix Degradation During Vascular Atrophy Researchers hypothesized that matrix loss would be linked to smooth muscle cell death, but the factors and mechanisms involved are not known. [J Vasc Surg] Microfluidic Assay of Endothelial Cell Migration in 3D Interpenetrating Polymer Semi-Network HA-Collagen Hydrogel Researchers report a microfluidic assay of endothelial cell sprouting and migration into an interpenetrating polymer semi-network HA-Collagen hydrogel as extracellular matrix providing an enhanced in vivo mimicking 3D microenvironment to cells. [Biomed Microdevices] Mechanical Evaluation of Decellularized Porcine Thoracic Aorta The effects of different decellularization protocols on the (passive) mechanical properties of the resulted porcine aortic extracellular matrix were evaluated. [J Surg Res] Regulation of Osteogenic and Chondrogenic Differentiation of Mesenchymal Stem Cells in PEG-ECM Hydrogels The microenvironments created by exogenous extracellular matrix (ECM) components seem to modulate the fate of mesenchymal stem cell differentiation. [Cell Tissue Res] Grooved Surface Topography Alters Matrix-Metalloproteinase Production by Human Fibroblasts The aim of this project was to determine if culturing fibroblasts on grooved topography altered collagen deposition or matrix-metalloproteinase production. [Biomed Mater] |