Extracellular Matrix News Volume 2.39 | Oct 6 2011

Modulation of Canonical Wnt Signaling by the Extracellular Matrix Component Biglycan
In the present study, researchers show that a member of the small leucine-rich proteoglycan family, biglycan, enhances canonical Wnt signaling by mediating Wnt function via its core protein. [Proc Natl Acad Sci USA] Abstract

In Situ AFM Study of Amelogenin Assembly and Disassembly Dynamics on Charged Surfaces Provides Insights on Matrix Protein Self-Assembly
Here researchers report the results of an in situ atomic force microscopy study of self-assembly by amelogenin—the principal protein of the extracellular matrix in developing enamel—in contact with two different charged substrates: hydrophilic negatively charged bare mica and positively charged 3-aminopropyl triethoxysilane silanized mica. [J Am Chem Soc] Abstract

Damage Associated Molecular Patterns within Xenogeneic Biologic Scaffolds and Their Effects on Host Remodeling
The present study investigated the immunomodulatory effects of common extracellular matrix scaffolds. [Biomaterials] Abstract

Enhancement of Mesenchymal Stem Cell Angiogenic Capacity and Stemness by a Biomimetic Hydrogel Scaffold
In this study, researchers examined the capacity of a biomimetic pullulan–collagen hydrogel to create a functional biomaterial-based stem cell niche for the delivery of mesenchymal stem cells into wounds. [Biomaterials] Abstract

Cartilage Regeneration in SCID Mice using a Highly Organized Three-Dimensional Alginate Scaffold
This highly organized 3D alginate scaffold provided a suitable environment and maintained functional phenotypes for chondrocytes in this animal study. [Biomaterials] Abstract

Engineering of Living Autologous Human Umbilical Cord Cell-Based Septal Occluder Membranes using Composite PGA-P4HB Matrices
Here, researchers present the in vitro fabrication, crimping and experimental delivery of living human umbilical cord-cell derived TEOMs based on composite matrices as a potential future autologous therapy of intracardiac wall defects. [Biomaterials] Abstract

Step-Wise Proteolytic Activation of Type I Procollagen to Collagen within the Secretory Pathway of Tendon Fibroblasts In Situ
In conclusion, the N-propeptides are removed earlier in the secretory pathway than the C-propeptides. The removal of the C-propeptides in post-Golgi compartments most probably indicates preparation of collagen molecules for fibril formation at the cell-matrix interface. [Biochem J] Abstract

A Novel Method for the Fabrication of Fibrin-Based Electrospun Nanofibrous Scaffold for Tissue-Engineering Applications
In this study, fibrin, which is superior to fibrinogen in both structural and functional properties, has for the first time been electrospun successfully into uniform nano fibers resembling the extracellular matrix. [Tissue Eng Part C Methods] Abstract

Video-Rate Bioluminescence Imaging of Matrix Metalloproteinase-2 Secreted from a Migrating Cell
Researchers were the first to successfully demonstrate secretory dynamics of MMP-2 and the specific sites for polarized distribution of MMP-2 on the cell surface. [PLoS ONE] Abstract

Impact of Bladder-Derived Acellular Matrix, Growth Factors, and Extracellular Matrix Constituents on the Survival and Multipotency of Marrow-Derived Mesenchymal Stem Cells
Researchers investigate the effect of bladder-derived acellular matrix on bone marrow mesenchymal stem cells (BM-MSC) growth, survival, and differentiation, and evaluate the effect of collagen I and IV on BM-MSC differentiation potential to SMC. [J Biomed Mater Res A] Abstract

Phosphorylation of Extracellular Matrix Tenascin-X Detected by Differential Mass Tagging Followed by NanoLC-MALDI-TOF/TOF-MS/MS Using ProteinPilot Software
MS/MS analysis revealed a novel phosphorylation site of tenascin-X, Thr1841, located in the loop region between the 10th and 11th fibronectin type III repeats. [Connect Tissue Res] Abstract

Halozyme Begins Randomized, Controlled Clinical Trial with PEGPH20 in Patients with Advanced Pancreatic Cancer
Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the diabetes, cancer, dermatology and drug delivery markets, announced the commencement of patient dosing in a Phase 2 clinical trial with pegylated rHuPH20 (PEGPH20) in patients with stage IV previously untreated pancreatic cancer. [Halozyme Therapeutics, Inc.] Press Release

The Centre for Commercialization of Regenerative Medicine (CCRM): CCRM Announces Its Inaugural Board of Directors
The Centre for Commercialization of Regenerative Medicine (CCRM) is proud to announce its inaugural Board of Directors. [Reuters] Press Release

NCI Renews UAB Comprehensive Cancer Center’s $27.5 Million Core Grant
The University of Alabama at Birmingham (UAB) Comprehensive Cancer Center has received a five-year, $27.5 million Cancer Center Support Grant from the National Cancer Institute (NCI) to renew support for its cancer research program through 2016. [University of Alabama] Press Release

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NEW World Stem Cells & Regenerative Medicine Congress 2012
May 21-23, 2012
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

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Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Post-Doctoral Position: Extracellular Matrix and Tendon Development (Institut de Génomique Fonctionnelle de Lyon)

Post-Doctoral Research Associate (Tina Izard Lab) – Cancer Biology (Scripps Florida)

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