Extracellular Matrix News Volume 2.44 | Nov 10 2011

Myocardin Related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung Fibroblasts
Researchers findings show that myocardin related transcription factor-A is an important regulator of collagen synthesis in lung fibroblasts and exhibits a dependence on both serum response factor and Sp1 function to enhance collagen expression. [J Biol Chem] Abstract

Genetic and Epigenetic Inactivation of Extracellular Superoxide Dismutase Promotes an Invasive Phenotype in Human Lung Cancer by Disrupting ECM Homeostasis
Researchers hypothesized that extracellular superoxide dismutase loss could affect malignant progression in lung, and could be either genetic or epigenetic in nature. [Mol Cancer Res] Abstract

Adhesive F-Actin Waves: A Novel Integrin-Mediated Adhesion Complex Coupled to Ventral Actin Polymerization
Here researchers show that integrins engage the extracellular matrix downstream of ventral F-actin waves in several mammalian cell lines as well as in primary mouse embryonic fibroblasts. [PLoS One] Abstract

Progressive Induction of Left Ventricular Pressure Overload in a Large Animal Model Elicits Myocardial Remodeling and a Unique Matrix Signature
Determinants of extracellular matrix remodeling were assessed by measuring levels of mRNA expression for fibrillar collagens, matrix metalloproteinases, and tissue inhibitors of matrix metalloproteinase 1 and 4. [J Thorac Cardiovasc Surg] Abstract

Extracellular Matrix Elasticity Modulates TGF-β-Induced p38 Activation and Myofibroblast Transdifferentiation in Human Tenon Fibroblasts
Here researchers study the impact of extracellular matrix elasticity on TGF-β-induced signal transduction and myofibroblast transdifferentiation. [Invest Ophthalmol Vis Sci] Abstract

The Effects of Fibrin and Fibrin-Agarose on the Extracellular Matrix Profile of Bioengineered Oral Mucosa
This study compared the histology and expression of several extracellular matrix molecules in human artificial oral mucosa developed using two different types of scaffolds: fibrin and fibrin-agarose. [J Tissue Eng Regen Med] Abstract

Microarray-Based Identification of Aminopeptidase N/CD13 Target Genes in Keratinocyte Conditioned Medium-Stimulated Dermal Fibroblasts
The present study examines whether modulation of aminopeptidase N gene expression has any impact on the fibroblast extracellular matrix gene expression profile. [J Cell Biochem] Abstract

Tumor Necrosis Factor-Alpha and Receptor Activator of Nuclear Factor-κB Ligand Augment Human Macrophage Foam-Cell Destruction of Extracellular Matrix through Protease-Mediated Processes
The aims of the present study were to investigate the in vitro role of human macrophage foam cells in degrading type I collagen and to establish whether the pro-inflammatory molecules, tumor necrosis factor-alpha, and receptor activator of nuclear factor-κB ligand increase this degradation. [Assay Drug Dev Technol] Abstract

Effects of Maternal Food Restriction on Offspring Lung Extracellular Matrix Deposition and Long Term Pulmonary Function in an Experimental Rat Model
Researchers hypothesized that intrauterine growth restriction (IUGR) following maternal food restriction would affect extracellular matrix deposition in the lung, explaining the long-term impairment in pulmonary function in the IUGR offspring. [Pediatr Pulmonol] Abstract

Kensey Nash Corporation Receives $1.9 Million NIH Grant for Tendon Product Research
The National Institutes of Health (NIH) has awarded Kensey Nash Corporation a two-year, $1.9 million Phase II Small Business Innovation Research grant to further investigate the use of a bioadhesive surgical mesh for applications in tendon repair procedures. [Kensey Nash Corporation] Press Release

UCSF Training Program Attracts Best Minds in Developmental, Stem Cell Biology
Fittingly enough for a University where embryonic stem cells were first discovered in mice and named, the University of California, San Francisco (UCSF) has launched a pioneering program in Developmental and Stem Cell Biology. [University of California, San Francisco] Press Release

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Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Post-Doctoral/Research Scientist – (Mount Sinai School of Medicine)

Post-Doctoral Positions (Finnish Centre of Excellence in Cell-Extracellular Matrix Research) 

Post-Doctoral – Extracellular Matrix Laboratory (University of Pennsylvania)

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