Extracellular Matrix News Volume 2.49 | Dec 15 2011

Membrane Type Matrix Metalloproteinase 1 Regulates the Turnover and Endocytosis of Extracellular Matrix Fibronectin
In this study, scientists examined the role of extracellular proteases in regulating extracellular matrix fibronectin turnover. [J Cell Sci] Abstract

Laminin Stimulates Proliferation of Mouse Embryonic Stem Cells through a Reduction of Gap Junctional Intercellular Communication via RhoA-Mediated Cx43 Phosphorylation and Dissociation of Cx43/ZO-1/Drebrin Complex
Researchers examined the role of laminin-111 in the control of connexin (Cx) 43 functions and related signal pathways in mouse embryonic stem cells. [Stem Cells Dev] Abstract

Functional Role of Scaffold Geometries as a Template for Physiological Extracellular Matrix Formation: Evaluation of Collagen 3D Assembly
This work aimed to evaluate the efficiency of different scaffold geometries with a novel approach: exploring the relationships among scaffold morphologies, cell activity and collagen three-dimensional (3D) organization. [J Tissue Eng Regen Med] Abstract

Effects of Decorin and Biglycan on Human Airway Smooth Muscle Cell Adhesion
Growth on a decorin matrix results in decreased human airway smooth muscle cell number, by decreasing proliferation and increasing apoptosis. In this study, researchers questioned whether these effects were related to abnormal extracellular matrix-cell adhesion. [Matrix Biol] Abstract

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration
Using in vitro and ex vivo models of vessel wall stiffness and aging, researchers show that stiffening of extracellular matrix within the intima promotes endothelial cell permeability – a hallmark of atherogenesis. [Sci Transl Med] Abstract

Fibroblast Morphology on Dynamic Softening of Hydrogels
Despite cellular environments having dynamic characteristics, many laboratories utilized static polyacrylamide hydrogels to study the extracellular matrix-cell relationship. To attain a more in vivo like environment, researchers have developed a dynamic, DNA-crosslinked hydrogel. [Ann Biomed Eng] Abstract

Novel Biodegradable, Biomimetic and Functionalized Polymer Scaffolds to Prevent Expansion of Post-Infarct Left Ventricular Remodeling
The aim of this study was to develop a three-dimensional scaffold to treat cardiac failure. [J Mater Sci Mater Med] Abstract

BioTime Successfully Completes HyStem®-Rx Preclinical ISO 10993 Studies
BioTime, Inc. announced the successful completion of ISO 10993 biocompatibility studies for HyStem^®-Rx, a proprietary biocompatible hydrogel that mimics the human extracellular matrix. [BioTime, Inc.] Press Release

Collaboration Aimed at Automating Manufacturing of Regenerative Medicine Therapies
Wake Forest Baptist Medical Center’s Institute for Regenerative Medicine is teaming up with North Carolina State University’s Edward P. Fitts Department of Industrial and Systems Engineering with the goal of applying the latest advances in industrial engineering to the new field of regenerative medicine. [Wake Forest Baptist Medical Center] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Positions – Tissue-Engineering (Sabanci University)

Research Associate – Adult Stem Cell Research (Purdue University)

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