| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Abnormal Bone Quality in COMP and Matrilin-3 Double Deficient Mice Caused by Increased TIMP-3 Deposition and Delayed Aggrecan Degradation Given the similar function of COMP and matrilin-3 in the assembly and stabilization of the extracellular matrix, it should be determined if these proteins can functionally compensate for each other. To assess this putative redundancy researchers generated COMP/matrilin-3 double deficient mice and performed an in-depth analysis of their skeletal development. [Arthritis Rheum] Abstract The Cartilage Matrix Molecule Components Produced by Human Fetal Cartilage Rudiment Cells within Scaffolds and the Role of Exogenous Growth Factors This study examined the matrix components elaborated by cultured fetal cartilage rudiment cells, a mixture of chondroblasts/chondroprogenitor cells and committed chondrocytes, in monolayer, cell pellet cultures and in the synthetic scaffolds sodium alginate and polyglycolic acid. [Biomaterials] Abstract Modulation of Mesenchymal Stem Cell Chondrogenesis in a Tunable Hyaluronic Acid Hydrogel Microenvironment In this study, hyaluronic acid-tyramine hydrogels were explored as biomimetic matrices for caprine mesenchymal stem cells in cartilage tissue engineering. [Biomaterials] Abstract The Effects of the Modulation of the Fibronectin-Binding Capacity of Fibrin by Thrombin on Osteoblast Differentiation In this study, researchers provide evidence that thrombin engaged with fibrin accelerates osteoblast differentiation via integrins but not protease-activated receptor 1 by modulating the fibronectin-binding capacity of fibrin. [Biomaterials] Abstract The Non-Coding 3’UTR of CD44 Induces Metastasis by Regulating Extracellular Matrix Functions Genes encoding the extracellular matrix normally produce large mRNA transcripts including the 3′ untranslated region (UTR). Researchers hypothesized that the increased expression of the CD44 3’UTR affected microRNA binding and modulated synthesis of the extracellular matrix. [J Cell Sci] Abstract Extracellular Matrix Secreted by Reactive Stroma Is a Main Inducer of Pro-Tumorigenic Features on LNCaP Prostate Cancer Cells Using in vitro functional assays, researchers demonstrated that extracellular matrix strongly stimulated LNCaP cell proliferation and migration, while inhibiting apoptosis, and inducing a deregulated expression pattern of several genes related to prostate cancer progression. [Cancer Lett] Abstract Rat Tail Static Compression Model Mimics Extracellular Matrix Metabolic Imbalances of Matrix Metalloproteinases, Aggrecanases, and Tissue Inhibitors of Metalloproteinases in Intervertebral Disc Degeneration The longitudinal degradation mechanism of extracellular matrix in the intervertebral disc remains unclear. Researchers’ objective was to elucidate catabolic and anabolic gene expression profiles and their balances in intervertebral disc degeneration using a static compression model. [Arthritis Res Ther] Abstract Preparation and Characterization of Decellularized Tendon Slices for Tendon Tissue Engineering To develop a naturally derived tendon tissue engineering scaffold with the preservation of the native ultrastructure, tensile strength, and biochemical composition of the tendon extracellular matrix, decellularized tendon slices were prepared using repetitive freeze/thaw of the intact Achilles tendons, frozen section, and nuclease treatment. [J Biomed Mater Res A] Abstract |
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