Extracellular Matrix News Volume 3.13 | Apr 5 2012

    0
    28

    Extracellular Matrix News 3.13, April 5, 2012
         In this issue: Publications | Industry News | Policy News | Events | Jobs
    Cell Therapy News on Facebook  Extracellular Matrix News on Twitter

    TOP STORY

    Tissue Specific Synthetic ECM Hydrogels for Three-Dimensional In Vitro Maintenance of Hepatocyte Function
    Researchers investigated whether extracts prepared from acellular liver extracellular matrix (ECM), or from whole liver tissue, could be combined with collagen type I, hyaluronic acid (HA), or heparin-conjugated HA hydrogels to enhance survival and functional output of primary human hepatocytes. [Biomaterials] Abstract

    Register for Free Webinar April 17: PneumaCult™-ALI for Bonchial Epithelial Cells.

    PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Hyaluronan Impairs Vascular Function and Drug Delivery in a Mouse Model of Pancreatic Cancer
    Scientists examined the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan, as a novel therapeutic target in pancreatic ductal adenocarcinoma. [Gut] Abstract

    N-Cadherin-Mediated Cell-Cell Adhesion Promotes Cell Migration in a Three-Dimensional Matrix
    Using hepatocyte growth factor-treated MDCK cells that underwent a complete epithelial-to-mesenchymal transition, researchers analyzed cell-cell adhesion between these highly invasive transformed epithelial cells in a three-dimensional collagen matrix. [J Cell Sci] Abstract

    MT1-MMP-Dependent Remodeling of Cardiac Extracellular Matrix Structure and Function following Myocardial Infarction
    This study identified MT1-matrix metalloproteinase (MMP) as a key MMP responsible for effecting postinfarction cardiac extracellular matrix remodeling and cardiac dysfunction. [Am J Pathol] Abstract

    Three-Dimensional Electrospun Poly(Lactide-co-ε-Caprolactone) for Small Diameter Vascular Grafts
    Researchers studied small diameter vascular grafts in vitro by seeding smooth muscle cells on the electrospun poly(lactide-co-ε-caprolactone) scaffolds, culturing and constructing a three-dimensional network. [Tissue Eng Part A] Abstract

    Matrix Stiffness-Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction
    Researchers aimed to determine the intrinsic mechanisms of mechanotransduction in the regulation of matrix stiffness-induced myofibroblast differentiation. [Am J Respir Cell Mol Biol] Abstract

    Heparin Interacting Protein Mediated Assembly of Nano-Fibrous Hydrogel Scaffolds for Guided Stem Cell Differentiation
    These studies demonstrated that a nano-fibrous hyaluronic acid hydrogel can render the formulation of a therapeutically effective platform for in vitro adipogenesis applications. [Macromol Biosci] Abstract

    Age Impacts Extracellular Matrix Metabolism in Chondrocytes Encapsulated in Degradable Hydrogels
    Scientists compare extracellular matrix anabolic and catabolic metabolisms by juvenile and adult chondrocytes in hydrolytically degradable hydrogels. [Biomed Mater] Abstract

    Improved Cartilage Repair via In Vitro Pre-Maturation of MSC-Seeded Hyaluronic Acid Hydrogels
    Researchers assess both the maturation and integration of mesenchymal stem cell (MSC)-laden hyaluronic acid hydrogels in an in vitro cartilage defect model. [Biomed Mater] Abstract

    Watch the Webinar: How Three Chimerism Groups Saved Time, Effort, and Money with RoboSep

    INDUSTRY NEWS

    Cardium Announces U.S. Market Introduction of Excellagen™
    Cardium Therapeutics announced market introduction of its Excellagen™ professional-use, syringe-based wound care product for the management of diabetic foot ulcers, pressure ulcers and other dermal wounds. [Cardium Therapeutics] Press Release

    REMEDI Announces Collaborations with Chinese Universities
    The Regenerative Medicine Institute (REMEDI) announced collaborations with both Shanghai Jiao Tong University and the Fourth Medical Military University Hospital in Xi’an. The agreement will see REMEDI work closely with both Chinese partners in a number of research areas and will facilitate student and researcher exchange between Galway and China. [The Regenerative Medicine Institute] Press Release

    POLICY NEWS

    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)
     
    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

    EVENTS

    NEW The 2nd International Symposium of Materials on Regenerative Medicine
    August 29-31, 2012
    Taipei, Taiwan

    Visit our events page to see a complete list of events in the extracellular matrix community.

    JOB OPPORTUNITIES
    Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

    Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

    Scientist – Hematology (STEMCELL Technologies, Inc.)

    Scientist – hPSC (STEMCELL Technologies, Inc.)

    Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

    Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

    Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

    Business Analyst – Product Management (STEMSOFT Software, Inc.)

    Postdoctoral Position (Thomas Jefferson University)


    Recruit Top Talent
    Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

    Jobs are categorized regionally: United States, Canada, Europe, Middle East to Asia Pacific

    Visit here to post your career opportunities.

    Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

    Comments or Suggestions? Email info@connexoncreative.com with your feedback.

    Learn more about Extracellular Matrix Cell News: Archives | Events | Contact Us