Extracellular Matrix News Volume 3.15 | Apr 19 2012

Interplay of Cell Adhesion Matrix Stiffness and Cell Type for Non-Viral Gene Delivery
Scientists report that the effect of matrix stiffness on non-viral gene delivery differs among cell types due to varying sensitivities to matrix rigidity. [Acta Biomater] Abstract

NEDD9 Stabilizes Focal Adhesions, Increases Binding to the Extracellular Matrix and Differentially Effects Two-Dimensional versus Three-Dimensional Cell Migration
Researchers’ data suggests that NEDD9 may promote three-dimensional cell migration by slowing focal adhesion disassembly, promoting integrin receptor activation and increasing adhesion force to the extracellular matrix. [PLoS One] Abstract

Cell Therapy Limits Myofibroblast Differentiation and Structural Cardiac Remodeling: bFGF-Mediated Paracrine Mechanism
The effect of cell therapy on post-infarction cardiac fibroblast and extracellular matrix regulation was examined. [Circ Heart Fail] Abstract

Specificity of Latent TGF-ß Binding Protein (LTBP) Incorporation into Matrix: Role of Fibrillins and Ribronectin
Scientists analyzed both in vitro and in vivo the role of fibrillin microfibrils in the matrix deposition of LTBP-1, -3 and -4. [J Cell Physiol] Abstract

Glycosaminoglycans Enhance Osteoblast Differentiation of Bone Marrow Derived Human Mesenchymal Stem Cells
Investigators confirmed and emphasized the significant role of extracellular matrix in regulating cell differentiation. [J Tissue Eng Regen Med] Abstract

Glycosaminoglycan Backbone Is Not Required for the Modulation of Hemostasis: Effect of Different Heparin Derivatives and Non-Glycosaminoglycan Analogs
Researchers examined a variety of heparinomimetics biochemically and pharmacologically, as well as their interactions with cells from the vessel wall using a time resolved fluorometric method and confocal microscopy. [Matrix Biol] Abstract

Endoplasmic Reticulum Stress Modulates Nicotine-Induced Extracellular Matrix Degradation in Human Periodontal Ligament Cells
Investigators examined whether endoplasmic reticulum stress was responsible for nicotine-induced cytotoxicity and extracellular matrix degradation. [J Periodontal Res] Abstract

Baxter and Halozyme Provide Update on HyQ Biologics License Application
Baxter International Inc. and Halozyme Therapeutics, Inc. announced that the U.S. Food and Drug Administration is requesting additional information to complete its review of the HyQ Biologics License Application. [Halozyme Therapeutics, Inc.] Press Release

Piramal Healthcare Announces Approval of Its First Innovative Product for Regenerative Medicine, BST-CarGel®
Piramal Healthcare Limited announced that it has received the European CE mark approval for its innovative bio-orthopedic product for cartilage repair, BST-CarGel®. [Piramal Healthcare Limited] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Federation of American Societies for Experimental Biology (FASEB) – Smooth Muscle Conference
June 24-29, 2012
Snowmass Village, United States

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