Extracellular Matrix News Volume 3.16 | Apr 26 2012

The Impact of Substrate Stiffness and Mechanical Loading on Fibroblast-Induced Scaffold Remodeling
Investigators aimed to gain insight into how mechanical boundary conditions affect the production of extracellular matrix components, their remodeling and the feedback of the altered mechanical cell environment on these processes. [Tissue Eng Part A] Abstract

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signaling
Scientists’ results suggested that ACE2 plays a role in cell-cell interactions, possibly acting to fine-tune integrin signaling. [PLoS One] Abstract

Anthrax Toxin Receptor 2 Functions in Extracellular Matrix Homeostasis of the Murine Reproductive Tract and Promotes MMP Activity
Histological analysis of the uterus and cervix revealed aberrant deposition of extracellular matrix proteins such as type I collagen, type VI collagen and fibronectin. [PLoS One] Abstract

Disorganized Collagen Scaffold Interferes with Fibroblast Mediated Deposition of Organized Extracellular Matrix In Vitro
Two established corneal stroma tissue engineering culture systems were compared to determine if the presence of disorganized collagen gel influenced matrix production and organizational control exerted by primary human corneal fibroblast cells. [Biotechnol Bioeng] Abstract

Bone Matrix Osteonectin Limits Prostate Cancer Cell Growth and Survival
To determine how bone matrix osteonectin affects the behavior of prostate cancer cells, researchers modeled prostate cancer cell-bone interactions using the human prostate cancer cell line PC-3, and mineralized matrices synthesized by wild type and osteonectin-null osteoblasts in vitro. [Matrix Biol] Abstract

Tumor Suppression by Collagen XV Is Independent of the Restin Domain
Researchers showed that expression of collagen XV enhances the adhesion of cervical carcinoma cells to collagen I in vitro as does the N-terminus and collagenous regions of collagen XV, but not the restin domain. [Matrix Biol] Abstract

Characterization of a S-Layer Protein from Lactobacillus crispatus K313 and the Domains Responsible for Binding to Cell Wall and Adherence to Collagen
Binding to immobilized types I and IV collagen was observed with His-surface (S)-layer protein B1-379 peptides, suggesting that the extracellular matrix protein-binding domain was located in the N terminus. [Appl Microbiol Biotechnol] Abstract

Stirred Flow Bioreactor Modulates Chondrocyte Growth and Extracellular Matrix Biosynthesis in Chitosan Scaffolds
Researchers aimed to show the favorable effect of simple dynamic culture conditions on chondrogenesis of previously expanded human chondrocytes seeded in a macroporous scaffold with week cell-pore walls adhesion. [J Biomed Mater Res A] Abstract

Organogenesis Inc. Announces Major Milestones in Improved Apligraf^® Reimbursement and Access to Care for Patients Suffering from Chronic Wounds
Organogenesis Inc. announced that Apligraf^® has established improved coverage from multiple payors, improving access to care for millions of patients suffering from chronic, non-healing wounds. [Organogenesis Inc.] Press Release

New Research Center Unveiled at Annual Ohio State Conference
The Ohio State University has established a partnership of experts who will work together to discover novel treatments to accelerate wound healing and rehabilitation for patients. Ohio State’s Center for Regenerative Medicine and Cell-Based Therapies was created to further develop the research programs in these respective fields. [The Ohio State University Wexner Medical Center] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Gordon Research Conference: Vascular Cell Biology
January 27-February 1, 2013
Ventura, United States

NEW Gordon Research Conference: Fibronectin, Integrins & Related Molecules
February 10-15, 2013
Ventura, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or Suggestions? Email info@connexoncreative.com with your feedback.