Extracellular Matrix News Volume 3.22 | Jun 7 2012

Injectable Skeletal Muscle Matrix Hydrogel Promotes Neovascularization and Muscle Cell Infiltration in a Hindlimb Ischemia Model
Researchers aimed to develop a clinically relevant injectable hydrogel derived from decellularized skeletal muscle extracellular matrix and examine its potential for treating peripheral artery disease as a stand-alone therapy by studying the material in a rat hindlimb ischemia model. [Eur Cell Mater] Abstract

Fibulin-3 Promotes Glioma Growth and Resistance through a Novel Paracrine Regulation of Notch Signaling
The findings of this study highlight a major role for the tumor extracellular matrix in regulating glioma invasion and resistance to apoptosis via activation of the key Notch pathway. [Cancer Res] Abstract

Functionalization of Dynamic Culture Surfaces with a Cartilage Extracellular Matrix Extract Enhances Chondrocyte Phenotype against Dedifferentiation
Researchers showed that functionalization of extendable culture surfaces with cartilage extracellular matrix extract supports enhanced preservation of chondrocyte phenotype. [Acta Biomater] Abstract

Thick Acellular Heart Extracellular Matrix with Inherent Vasculature: Potential Platform for Myocardial Tissue Regeneration
Researchers focused on optimizing the decellularization procedure for thicker tissue slabs, retaining their inherent vasculature, and on characterizing the resulting porcine cardiac extracellular matrix. [Tissue Eng Part A] Abstract

A Biomechanical Role for Perlecan in the Pericellular Matrix of Articular Cartilage
Researchers aimed to determine the biomechanical role of perlecan in the articular cartilage pericellular matrix (PCM) in situ and its potential as a defining factor of the PCM. [Matrix Biol] Abstract

Deconstructing the Perineuronal Net: Cellular Contributions and Molecular Composition of the Neuronal Extracellular Matrix
Investigators provide deeper insight into the complex interplay between neurons and glia in the formation of the perineuronal nets and improve our understanding of the molecular composition of these structures. [Neuroscience] Abstract

Extracellular Matrix Protein Mediated Regulation of the Osteoblast Differentiation of Bone Marrow Derived Human Mesenchymal Stem Cells
Scientists examined the role of extracellular matrix proteins such as collagen type I, fibronectin, laminin and vitronectin in regulating the proliferation and osteogenic differentiation of bone marrow derived human mesenchymal stem cells. [Differentiation] Abstract

Healthpoint Biotherapeutics Signs Brazilian Distribution Agreement for OASIS® Extracellular Matrix Product Line
Healthpoint Biotherapeutics announced that the company has entered into a distribution agreement with Efe Consultoria & Importação Ltda to commercialize the OASIS® Extracellular Matrix product line in Brazil. [Healthpoint Biotherapeutics] Press Release

New Tissue Engineering Technology Moves from Lab toward Operating Room with Help from Virginia-Based Start-Up Eqalix, Inc.
A trio of tissue engineering technologies developed by researchers and clinicians from Drexel, Penn and The Children’s Hospital of Philadelphia are moving one step closer to becoming viable options for vascular surgery, skin replacement and tissue regeneration. [Eqalix, Inc.] Press Release

29 Johns Hopkins Stem Cell Researchers Awarded Funding from the Maryland Stem Cell Research Fund
The Maryland Stem Cell Research Fund awarded 29 of 40 grants to Johns Hopkins researchers for the study of stem cell metabolism and regulation, the creation of new cell models for human diseases such as schizophrenia and Rett syndrome and the development of new potential therapies. [The Johns Hopkins University] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Keystone Symposia on Molecular and Cellular Biology: Cardiac Remodeling, Signaling, Matrix and Heart Function
April 7-12, 2013
Snowbird, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Postdoctoral Research Fellow – Protein Chemistry/Immuno-Receptor Biology (Genentech)

Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Temporary Research Associate Position – Extracellular Matrix and Stem Cell Application in Regenerative Medicine (Università di Pisa)

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