Extracellular Matrix News Volume 3.25 | Jun 28 2012

Multistep Molecular Mechanism for Bone Morphogenetic Protein Extracellular Transport in the Drosophila Embryo
Researchers propose that regulation of bone morphogenetic protein (BMP) shuttling and immobilization through extracellular matrix interactions is widely used, both during development and in tissue homeostasis, to achieve a precise extracellular BMP distribution. [Proc Natl Acad Sci USA] Abstract | Full Article

Hyaluronic Acid-Binding Scaffold for Articular Cartilage Repair
Investigators developed a poly(ethylene glycol) hydrogel with non-covalent hyaluronic acid-binding capabilities and evaluated its ability to support cartilage formation in vitro and in an articular defect model. [Tissue Eng Part A] Abstract

Breast Tumor Initiating Cell Fate Is Regulated by Microenvironmental Cues from an Extracellular Matrix
Researchers studied how the tumor-initiating cell population would respond when subjected to a unique microenvironment composed of different extracellular proteins. [Integr Biol] Abstract

HSP47 Regulates ECM Accumulation in Renal Proximal Tubular Cells Induced by TGF-β1 through ERK1/2 and JNK MAPK Pathway
Scientists suggest that ERK1/2 and JNK signaling events are involved in modulating the expression of heat shock protein 47 (HSP47), the chaperoning effect of which on transforming growth factor-β1 (TGF-β1) would ultimately contribute to renal fibrosis by enhancing the extracellular matrix (ECM) proteins synthesis and deposition. [Am J Physiol Renal Physiol] Abstract

In Vitro and In Vivo Evaluation of a Biphasic Calcium Phosphate Scaffold Coated with a Native Allogeneic Extracellular Matrix
Scientists evaluated the osteogenic properties of biphasic calcium phosphate scaffolds coated with extracellular matrix derived in vitro from allogeneic mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract

Artificial Extracellular Matrices of Collagen and Sulphated Hyaluronan Enhance the Differentiation of Human Mesenchymal Stem Cells in the Presence of Dexamethasone
Researchers investigated the potential of artificial extracellular matrix coatings containing collagen II and two types of glycosaminoglycan with different degrees of sulphation to promote human bone formation in biomedical applications. [J Tissue Eng Regen Med] Abstract

Inhibitory Effect of Ginsenoside Rg1 on Extracellular Matrix Production via Extracellular Signal-Regulated Protein Kinase/Activator Protein 1 Pathway in Nasal Polyp-Derived Fibroblasts
Scientists investigated the effect of Rg1 on transforming growth factor-β1-induced myofibroblast differentiation and extracellular matrix production and to determined the molecular mechanism of Rg1 in nasal polyp-derived fibroblasts. [Exp Biol Med] Abstract

Functionalization of PLLA Nanofiber Scaffolds Using a Possible Cooperative Effect between Collagen Type I and BMP-2: Impact on Colonization and Bone Formation In Vivo
Differentiation is triggered by a series of signaling processes, including integrin and bone morphogenetic protein (BMP), which act in a cooperative manner. Researchers analyzed whether these processes can be remodeled in artificial poly-(l)-lactide acid (PLLA) based nanofiber scaffolds in vivo. [J Mater Sci Mater Med] Abstract

Rensselaer and New York State Launch New Stem Cell Research Center
Ground-breaking research to advance the application of stem cells to address critical injuries and diseases will be taking place at Rensselaer Polytechnic Institute, in a new center funded by New York state. [Rensselaer Polytechnic Institute] Press Release

Specialist Funds Launched to Support Novel Regenerative Therapies
Regener8 and the Medical Technologies Innovation and Knowledge Centre launched a call for five Proof of Concept awards of up to £100K to fund projects that align with the therapeutic priorities identified in the Research Councils UK Regenerative Medicine Strategy. [University of Leeds] Press Release

We care what you think! Please help Connexon Creative improve our newsletters by taking our survey. For responding, you will be entered in a draw to win one of 50 Starbucks gift cards valued at $10 each!* Enter here *Starbucks promotion only applies where Starbucks gift cards are redeemable. Prizes will be given at random when survey closes.

U.K. Panel Backs Open Access for All Publicly Funded Research Papers
A long-awaited government report in the United Kingdom says open access journals should be “the main vehicle for the publication of research.” But it warns that such a move would cost the United Kingdom more than $80 million per year in publication charges and other costs. [The Working Group on Expanding Access to Published Research Findings, United Kingdom] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Gordon Research Conference: Fibronectin, Integrins & Related Molecules – Dissecting Cell-Matrix Adhesions
February 9-10, 2013
Ventura, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Research Fellow – Protein Chemistry/Immuno-Receptor Biology (Genentech)

Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Assistant Professor – Cell and Extracellular Matrix Research (University of Oulu)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or Suggestions? Email info@connexoncreative.com with your feedback.