Extracellular Matrix News Volume 3.28 | Jul 19 2012

Dystrophin and Utrophin Expression Require Sarcospan: Loss of α7 Integrin Exacerbates a Newly Discovered Muscle Phenotype in Sarcospan-Null Mice
Investigators demonstrated that sarcospan is a necessary component of dystrophin and utrophin function and that sarcospan modulation of integrin signaling is required for extracellular matrix attachment and muscle force development. [Hum Mol Genet] Abstract

The Osteogenic Differentiation of Human Bone Marrow MSCs on HUVEC-Derived ECM and ß-Tricalcium Phosphate Scaffold
Scientists report that extracellular matrix (ECM) derived from human umbilical vein endothelial cells (HUVEC) promotes osteogenic differentiation of human bone marrow mesenchymal stem cells (MSCs). [Biomaterials] Abstract

The Alignment and Fusion Assembly of Adipose-Derived Stem Cells on Mechanically Patterned Matrices
Researchers developed a mechanically-patterned hydrogel to observe and compare it to extracellular matrix ligand patterns to determine how to best regulate and improve cell type-specific behaviors. [Biomaterials] Abstract

Coordination of Fibronectin Adhesion with Contraction and Relaxation in Microvascular Smooth Muscle
Data support the hypothesis that regulation of cell adhesion is coordinated with contraction and demonstrate the dynamic nature of cell adhesion to the extracellular matrix. [Cardiovasc Res] Abstract

PTPα Phosphotyrosyl-789 Binds BCAR3 to Position Cas for Activation at Integrin-Mediated Focal Adhesions
Researchers revealed a novel role of protein tyrosine phosphatase α (PTPα) in integrin-induced adhesion assembly that enables Src-mediated activation of the pivotal function of Cas in migration. [Mol Cell Biol] Abstract

OmpL1 Is an Extracellular Matrix- and Plasminogen-Interacting Protein of Leptospira Spp.
Researchers characterized OmpL1 as an extracellular matrix-interacting and a plasminogen-binding protein of Leptospira spp. that, being expressed during infection, may play a role in the bacterial pathogenesis. [Infect Immun] Abstract

Pulsed-Low Intensity Ultrasound Enhances Extracellular Matrix Production by Fibroblasts Encapsulated in Alginate
The effect of pulsed-low intensity ultrasound on cell proliferation, collagen production and glycosaminoglycan deposition by 3T3 fibroblasts encapsulated in alginate was evaluated. [J Tissue Eng] Abstract | Full Article

Macrophages Alter the Differentiation-Dependent Decreases in Fibronectin and Collagen I/III Protein Levels in Human Preadipocytes
Findings indicated that macrophage-derived factors regulate levels of collagen I/III and fibronectin in preadipocytes under non-adipogenic and adipogenic conditions. [Lipids] Abstract

BioTime Signs Agreements with Jade Therapeutics for Ophthalmological Drug Delivery Applications of HyStem® Technology
BioTime, Inc. announced the signing of an exclusive sublicense agreement and a supply agreement with Jade Therapeutics, LLC. Under the agreements, BioTime will provide Jade with clinical-grade proprietary biocompatible hydrogels that mimic the human extracellular matrix (HyStem®) and certain patented technology for use by Jade Therapeutics in the development of new pharmaceutical products for ophthalmologic use. [BioTime, Inc.] Press Release

Biomedical Engineering Degree First in Western Canada
The University of Victoria is launching a new undergraduate biomedical engineering degree, the first of its kind west of Ontario. [University of Victoria] Press Release

EU Commission Backs Open-Access Science Publishing
The European Commission has backed calls for free access to publicly funded research in a move that could force a major change in the business model for publishers such as Reed Elsevier. [European Commission, Europe] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Gordon Research Conference: Matrix Metalloproteinases – Crucial Components of Molecular Networks and Disease Pathways
May 19-24, 2013
Lucca, Italy

Visit our events page to see a complete list of events in the extracellular matrix community.

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Assistant Professor – Cell and Extracellular Matrix Research (University of Oulu)

Professor – Molecular Cell-Extracellular Matrix Interplay (University of Oulu)

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