Extracellular Matrix News Volume 3.30 | Aug 2 2012

Molecular Crowding of Collagen: A Pathway to Produce Highly-Organized Collagenous Structures
Scientists report on a simple, fast, cell-free method capable of producing highly-organized, anistropic collagen fibrillar lamellae de novo, which persist over relatively long-distances. [Biomaterials] Abstract

Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity
Researchers suggest that tenascin C is involved in the etiopathology of obesity via visceral adipose tissue inflammation representing a link with extracellular matrix remodeling. [J Clin Endocrinol Metab] Abstract

ECM Stiffness Primes the TGFß Pathway to Promote Chondrocyte Differentiation
Researchers investigated mechanisms by which chondrocytes generate an integrated response to extracellular matrix (ECM) stiffness and TGFß, a potent agonist of chondrocyte differentiation. [Mol Biol Cell] Abstract

A Naturally-Derived Cardiac Extracellular Matrix Enhances Cardiac Progenitor Cell Behavior In Vitro
Researchers determined whether a naturally-derived cardiac extracellular matrix could enhance cardiac progenitor cell function in vitro. [Acta Biomater] Abstract

Contact Sensitizers Induce Skin Inflammation via Reactive Oxygen Species Production and Hyaluronic Acid Degradation
Scientists identified an indirect mechanism of contact sensitizer induced innate inflammatory signaling involving the breakdown of the extracellular matrix and generation of endogenous danger signals. [PLoS One] Full Article

Real-Time Monitoring of Adherence of Streptococcus anginosus Group Bacteria to Extracellular Matrix Decorin and Biglycan Proteoglycans in Biofilm Formation
Results suggest that Streptococcus anginosus groups bind to the extracellular matrix proteoglycans decorin and biglycan, with interaction mediated by the conjugated glycosaminoglycan chain. [Res Microbiol] Abstract

Extracellular Signal-Regulated Kinase Plays a Proapoptotic Role in Podocytes after Reactive Oxygen Species Treatment and Inhibition of Integrin-Extracellular Matrix Interaction
Researchers demonstrated that reactive oxygen species and blocking integrin-extracellular matrix interaction induce podocyte apoptosis, which is mediated by extracellular signal-regulated kinase activation. [Exp Biol Med] Abstract

Shedding of Kidney Injury Molecule-1 by Membrane-Type 1 Matrix Metalloproteinase
Results suggest that kidney injury molecule-1 (KIM-1) negatively regulates cellular function mediated through interaction with collagen, and membrane-type 1 matrix metalloproteinase abrogates it through the cleavage and shedding of KIM-1. [J Biochem] Abstract

Halozyme Confirms Baxter Has Received a Complete Response Letter for HyQ BLA
Halozyme Therapeutics, Inc. announced that the Center for Biologics Evaluation and Research of the U.S. Food and Drug Administration has issued a complete response letter for Baxter’s HyQ Biologics License Application (BLA). HyQ is an investigational product that includes plasma-derived immune globulin 10% and Halozyme’s recombinant human hyaluronidase for subcutaneous administration in patients with primary immunodeficiency disease. [Halozyme Therapeutics, Inc.] Press Release

Stem Cell Agency Commits $150 Million to Develop New Therapies
California’s stem cell agency, the California Institute for Regenerative Medicine approved $150 million in new funding to help move promising stem cell-based therapies from the laboratory research phase to clinical trials in people. [California Institute for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW STEM 2013: 9th Annual Conference – Society for Regenerative Medicine and Tissue Engineering
January 31-February 1, 2013
Bangalore, India

NEW Gordon Research Conference: Tissue Repair & Regeneration
June 16-21, 2013
New London, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Assistant Professor – Cell and Extracellular Matrix Research (University of Oulu)

Professor – Molecular Cell-Extracellular Matrix Interplay (University of Oulu)

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