Extracellular Matrix News Volume 3.31 | Aug 9 2012

Human Serine Protease HTRA1 Positively Regulates Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells and Mineralization of Differentiating Bone-Forming Cells through the Modulation of Extracellular Matrix Protein
Scientists investigated the role of HTRA1 in mesenchymal stem cell osteogenesis and suggested a potential mechanism through which it controls matrix mineralization by differentiating bone-forming cells. [Stem Cells] Abstract

Intrafibrillar Silicification of Collagen Scaffolds for Sustained Release of Stem Cell Homing Chemokine in Hard Tissue Regeneration
Researchers demonstrated that three-dimensional collagen scaffolds infiltrated with intrafibrillar silica are biodegradable and highly biocompatible. [FASEB J] Abstract

Influence of Select Extracellular Matrix Proteins on Mesenchymal Stem Cell Osteogenic Commitment in Three-Dimensional Contexts
Scientists examined the influence of select extracellular matrix proteins on mesenchymal stem cell osteogenesis toward the goal of developing scaffolds with intrinsically osteoinductive properties. [Acta Biomater] Abstract

Extracellular Matrix Lumican Promotes Bacterial Phagocytosis and Lum^-/- Mice Show Increased Pseudomonas aeruginosa Lung Infection Severity
Researchers showed a novel and critical role for lumican, the connective tissue extracellular matrix small leucine-rich repeat proteoglycan, in CD14-mediated bacterial phagocytosis. [J Biol Chem]
Abstract | Full Article

Diabetes Influences Cardiac Extracellular Matrix Remodeling after Myocardial Infarction and Subsequent Development of Cardiac Dysfunction
Investigators found that temporal changes in extracellular matrix remodeling correlated with exaggerated cardiac dysfunction in diabetic mice after myocardial infarction. [J Cell Mol Med] Abstract

In Vitro Model of Metastasis to Bone Marrow Mediates Prostate Cancer Castration Resistant Growth through Paracrine and Extracellular Matrix Factors
Scientists established an in vitro engineered bone marrow tissue model that incorporates human mesenchymal stem cells and bone marrow derived extracellular matrix (BM-ECM) to facilitate mechanistic studies of prostate cancer cell survival in androgen-depleted media in response to paracrine factors and BM-ECM. [PLoS One] Full Article

Mechanical and Biological Performances of New Scaffolds Made of Collagen Hydrogels and Fibroin Microfibers for Vascular Tissue Engineering
A microstructured composite material made of collagen hydrogel and silk fibroin microfibers was investigated in order to conjugate the mechanical resistance of fibroin with the suitable biological performance of collagen to design new scaffolds for vascular tissue engineering. [Macromol Biosci] Abstract

Expression Profile of Extracellular Matrix and Adhesion Molecules in the Development of Endometriosis in a Mouse Model
Researchers investigated the expression profile of extracellular matrix and adhesion molecules in the early steps of development of experimental mouse endometriosis, specifically in peritoneum adjacent to endometrium transplants attached via autotransplantation. [Reprod Sci] Abstract

NIH Announces Winners of Undergraduate Biomedical Engineering Competition
The National Institute of Biomedical Imaging and Bioengineering announced the winners in the three categories of the DEBUT challenge, a biomedical engineering design competition for teams of undergraduate students. [National Institutes of Health (NIH), United States] Press Release

CPRIT’s Governing Board Ratifies $114 Million in New Cancer Awards
The Cancer Prevention and Research Institute of Texas (CPRIT) announced funding of more than $114 million to support a variety of cancer-fighting efforts in Texas. The 45 newly funded projects and scientific recruits bring the total amount of grants awarded by CPRIT since its inception to more than $760 million. [Cancer Prevention Research Institute of Texas] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW World Stem Cells Regenerative Medicine Congress
May 21-23, 2013
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Assistant Professor – Cell Biology and Physiology (Washington University School of Medicine)

Assistant Professor – Cell and Extracellular Matrix Research (University of Oulu)

Postdoctoral Research Position – Molecular Cell Biology (Weizmann Institute of Science)

Professor – Molecular Cell-Extracellular Matrix Interplay (University of Oulu)

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