| PUBLICATIONS (Ranked by impact factor of the journal) | The Influence of Specific Binding of Collagen-Silk Chimeras to Silk Biomaterials on hMSC Behavior To explore the potential of collagen-silk chimera for regulating biological activity, integrin and fibronectin binding sequences from mammalian collagens were introduced into the Streptococcus pyogenes collagen domain. The attachment of bioactive collagen-silk chimeras to solid silk biomaterials promoted hMSC spreading and proliferation substantially in comparison to the controls. [Biomaterials] Abstract Alginate Hydrogel Has a Negative Impact on In Vitro Collagen 1 Deposition by Fibroblasts Hydrogels have been widely investigated as 3D culture substrates, because of their reported structural similarity to the extracellular matrix (ECM). Limited ECM deposition, however, occurs within these materials, so the resulting ‘tissues’ bear little resemblance to those found in the body. Here scientists investigated matrix deposition by fibroblasts encapsulated within a calcium alginate hydrogel. [Biomacromolecules] Abstract Organized Nanofibrous Scaffolds that Mimic the Macroscopic and Microscopic Architecture of the Knee Meniscus Researchers developed a novel electrospinning method to produce scaffolds composed of circumferentially aligned nanofibers, quantified their structure and mechanics, and compared them to traditional linearly aligned scaffolds. [Acta Biomater] Abstract HSP70 Increases Extracellular Matrix Production by Human Vascular Smooth Muscle through TGF-β1 Up-Regulation The authors hypothesized that extracellular heat shock protein (HSP)70 could interact with smooth muscle cells, inducing transforming growth factor type-β1 (TGF-β1) synthesis and subsequent changes in the vascular extracellular matrix. [Int J Biochem Cell Biol] Abstract Effectiveness of Nanometer-Sized Extracellular Matrix Layer-by-Layer Assembled Films for Cell Membrane Coating in Protecting the Cells from Physical Stress Damage to cell membranes can cause leakage of cytosol molecules or sometimes cell death. The authors evaluated the effectiveness of layer-by-layer films prepared on cell membranes in protecting cells from physical stresses. [Langmuir] Abstract Transient Soft-Tissue Edema Associated with Implantation of Increasing Doses of rhBMP-2 on an Absorbable Collagen Sponge in an Ectopic Rat Model Investigators examined soft-tissue edema associated with increasing secombinant human bone morphogenetic protein-2 (rhBMP-2) doses with implantation on an absorbable collagen sponge and with injection directly into muscle. [J Bone Joint Surg Am] Abstract Decellularized Ear Tissues as Scaffolds for Stem Cell Differentiation Decellularized extracellular matrix (ECM) has been used as a mechanical and biochemical scaffold for the induction of stem and other cells toward a target tissue phenotype. Scientists report the decellularization of the cochlea and identification of remaining laminin and collagen type IV as a first step in preparing an ECM scaffold for directing stem cells toward an auditory lineage. [J Assoc Res Otolaryngol] Abstract Effect of BDNF-Plasma-Collagen Matrix Controlled Delivery System on the Behavior of Adult Rats Neural Stem Cells The behavior of neural stem cells from the spinal cord of adult rats was compared at the neurosphere level after the respective addition of the brain-derived neurotrophic factor (BDNF) daily, the BDNF-loaded plasma-collagen matrix, the plasma-collagen matrix alone, or the defined medium alone. [J Biomed Mater Res A] Abstract Electrospinning Collagen/Chitosan/Poly(L-lactic acid-co-ϵ-caprolactone) to Form a Vascular Graft: Mechanical and Biological Characterization An elastic material of poly (L-lactic acid-co-ϵ-caprolactone), collagen and chitosan blended scaffold at different ratios were fabricated by electrospinning. The scaffolds were evaluated to determine the tensile strength, burst pressure, and dynamic compliance. In addition, the contact angle and endothelial cell proliferation on the scaffolds were evaluated to demonstrate the structures potential to serve as a vascular prosthetic capable of in situ regeneration. [J Biomed Mater Res A] Abstract Use of a Collagen Membrane Loaded with Collagen-Targeting Recombinant Human Bone Morphogenetic Protein-2 for Vertical Guided Bone Regeneration Investigators aimed to use a rabbit vertical guided bone regeneration model to evaluate whether using a collagen membrane loaded with small doses of collagen-targeting recombinant human bone morphogenetic protein-2 would enhance two-way vertical bone regeneration. [J Periodontol] Abstract |
|
|
|